| GeneLibs

题目:: Transcription profiling of BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis
ID:
状态:: 发布时间Feb. 21, 2009 , 更新时间 June 10, 2011 , 提交时间 Nov. 25, 2008,
物种:: Mus musculus
摘要:: BALB/c mice are susceptible to proteoglycan (PG) aggrecan-induced arthritis (PGIA), a murine model of rheumatoid arthritis (Glant,T.T. and Mikecz,K., Proteoglycan aggrecan-induced arthritis. A murine autoimmune model of rheumatoid arthritis. Methods Mol.Med. 2004. 102: 313-338.). However, there are marked differences among BALB/c colonies (maintained by different vendors at different locations) in PGIA onset and severity, which could be the result of subtle variations in their genetic background. In the present microarray study, we have identified differences among BALB/c colonies, and an altered immunization-related gene expression pattern in PGIA model. Experiment Overall Design: In this study we compared the gene expression profile of 12 spleens from PG-immunized (RNA was isolated 12 days after immunization) and naive mice from BALB/cJ and BALB/cByJ colonies (3-3 from each group), then made comparisons between colonies and based on immunization.
实验种类:: transcription profiling by array
样本量:: 12
实验设计:
: 无设计数据
数据号:: E-GEOD-13730, GSE13730
数据状态:: 无法自动分析，您可以尝试手动分析数据。

实验库数据相关信息