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题目:: Human ES cells reveal recurrent genomic instability at 20q11.21
ID:
状态:: 发布时间May 16, 2010 , 更新时间 May 1, 2014 , 提交时间 Nov. 12, 2008,
物种:: Homo sapiens
摘要:: By analyzing five human embryonic stem (hES) cell lines over long-term culture, we detected a recurrent genomic instability in the human genome. An amplification of 2.5–4.6 Mb at 20q11.21, encompassing about 23 genes in common, appeared in four cell lines of different origins. This amplification, which has been associated with oncogenic transformation, may provide a selective advantage to hES cells in culture Array-based comparative genomic hybridization, was performed on genomic DNA samples from different human embryonic stem cell lines, all cultured in our laboratory under the same conditions. VUB05-HD is an hES cell line carrying the Huntingtin mutant gene H1, H9, SA01, and VUB01 are various hES cell lines GSM341552 and GSM341553: SNP analysis GSM341589 to GSM341669: CGH analysis
实验种类:: genotyping by array, comparative genomic hybridization by array
样本量:: 24
实验设计:
: 无设计数据
数据号:: E-GEOD-13565, GSE13565
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