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题目:: Transcription profiling of Caenorhabditis elegans treated with Dichlorvos and fenamiphos, to investigate it as a genomic model for toxicology
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状态:: 发布时间June 24, 2009 , 更新时间 March 27, 2012 , 提交时间 July 30, 2008,
物种:: Caenorhabditis elegans
摘要:: Effective toxicological testing of the vast number of new and existing chemicals currently in use will require efficient and cost effective methods. We evaluated the utility of a simple, low cost toxicity testing system employing the nematode Caenorhabditis elegans to identify toxicologically relevant changes in gene expression. Dichlorvos and fenamiphos, which are organophosphorous pesticides that inhibit acetylcholinesterase were chosen as model toxicants to test the usefulness of the C. elegans toxicity testing system, and mefloquine, which appears to perturb neuronal Ca++ homeostasis, provided an out-group for analysis. Experiment Overall Design: Concentrations of dichlorvos, fenamiphos, or mefloquine sufficient to prevent the development of 10%, 50%, or 90% of mid-vulval L4 worms to the early gravid adult stage at 24 h after exposure were determined in range finding experiments. For definitive experiments, mid-vulval L4 worms were exposed to one of the foregoing concentrations of dichlorvos, fenamiphos, or mefloquine for 8h. Exposures were performed in triplicate.
实验种类:: transcription profiling by array
样本量:: 36
实验设计:
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数据号:: E-GEOD-12298, GSE12298
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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