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题目:: Transcription profiling of rat liver or brain cortex exposured to the explosive rexahydro-1,3,5-trinitro-1,3,5-triazine - RDX (3mg/kg or 18mg/kg; 0, 4, 24, 48 hr)
ID:
状态:: 发布时间March 21, 2009 , 更新时间 June 10, 2011 , 提交时间 July 22, 2008,
物种:: Rattus norvegicus
摘要:: RDX (Hexahydro-1,3,5-trinitro-1,3,5-triazine) is a synthetic, high-impact, relatively stable explosive that has been in use since WWII. Exposure to RDX can occur either occupationally or through ordnance that lays unexploded on training ranges. The toxicology of RDX is dominated by acute tonic-clonic seizures at high doses, which remit when exposure is removed and internal RDX levels decrease. Sub-chronic studies have revealed few other toxic effects. The objective of this study was to examine the effect of a single oral dose of RDX on global gene expression in the mammalian brain and liver, using a rodent model. Experiment Overall Design: Male Sprague-Dawley rats were given a single, oral, non-seizure inducing dose of either 3 or 18 mg/kg RDX in a gel capsule. Rats were euthanized at times 0, 4, 24, and 48 hours. RNA purified from brain cortex or liver was hybridized to Affymetrix rat 230.2 arrays.
实验种类:: transcription profiling by array
样本量:: 48
实验设计:
: 无设计数据
数据号:: E-GEOD-12196, GSE12196
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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