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题目:: Transcription profiling of CHUK deleted mouse keratinocytes compared to wild type mouse keratinocytes
ID:
状态:: 发布时间Aug. 12, 2009 , 更新时间 May 3, 2014 , 提交时间 July 14, 2008,
物种:: Mus musculus
摘要:: It has long been known that excessive mitotic activity due to H-Ras can block keratinocyte differentiation and cause skin cancer. It is not clear, however, whether there are any innate surveillants that ensure keratinocytes undergoing terminal differentiation, preventing the disease. IKKα induces keratinocyte terminal differentiation and its reduction promotes skin tumor development. However, its nature function in skin cancer is unknown. Here we found that mice with IKKα deletion in keratinocytes or in hair follicle keratinocytes developed a thickened epidermis and spontaneous squamous cell-like carcinomas. Inactivation of epidermal growth factor receptor (EGFR) or reintroduction of IKKα inhibited excessive mitosis, induced terminal differentiation, and prevented skin cancer through an EGFR-driven autocrine loop in mice. Thus, IKKα serves as an innate surveillant. Experiment Overall Design: The differences in gene expression profiles of CHUK deleted mouse keratinocytes compared to wild type mouse keratinocytes were analyzed using two dual-channel agilent microarrays in duplicates.
实验种类:: transcription profiling by array
样本量:: 4
实验设计:
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数据号:: E-GEOD-12111, GSE12111
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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