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题目:: Gpx3 male transgenic liver expression vs B6/DBA male wildtype control
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状态:: 发布时间March 7, 2009 , 更新时间 June 10, 2011 , 提交时间 July 2, 2008,
物种:: Mus musculus
摘要:: A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our method through the characterization of transgenic and knockout mouse models of candidate genes that were predicted to be causal for abdominal obesity. Perturbation of eight out of the nine genes, with Gas7, Me1 and Gpx3 being novel, resulted in significant changes in obesity related traits. Liver expression signatures revealed alterations in common metabolic pathways and networks contributing to abdominal obesity and overlapped with a macrophage-enriched metabolic network module that is highly associated with metabolic traits in mice and humans. Integration of gene expression in the design and analysis of traditional F2 intercross studies allows high confidence prediction of causal genes, and identification of involved pathways and networks. Keywords: Obesity study in transgenic animals A total of 8 mice were used for this study (4 Gpx3 transgenic and 4 B6/DBA wildtype). The gene expression data is from the livers of 23 week old male wildtype and transgenic mice. These mice were fed a 4% fat chow diet until 11 weeks of age and then were fed a 6% fat chow diet until sacrifice at 23 weeks of age.
实验种类:: transcription profiling by array
样本量:: 8
实验设计:
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数据号:: E-GEOD-11997, GSE11997
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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