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题目:: Transcription profiling of human cholangiocarcinoma cells (cholangiocytes) expressing IL-6
ID:
状态:: 发布时间Oct. 21, 2008 , 更新时间 May 1, 2014 , 提交时间 June 25, 2008,
物种:: Homo sapiens
摘要:: The association between chronic inflammation and the development and progression of malignancy is exemplified in the biliary tract where persistent inflammation strongly predisposes to cholangiocarcinoma. The inflammatory cytokine interleukin-6 (IL-6) enhances tumor growth in cholangiocarcinoma by altered gene expression via autocrine mechanisms. We therefore investigated the effect of chronic exposure to IL-6 on gene expression using malignant cholangiocytes stably transfected to overexpress IL-6. Comparison of gene expression identified several genes that were altered by enforced IL-6 expression. Experiment Overall Design: Mz-ChA-1 cells were stably transfected with a pTarget vector plasmid containing full length IL-6 under the control of a CMV promoter to generate Mz-IL6. Cells transfected with empty vector were used as control
实验种类:: transcription profiling by array
样本量:: 2
实验设计:
: 无设计数据
数据号:: E-GEOD-11883, GSE11883
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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