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题目:: Transcription profiling of mouse P21 cochlear nucleus after activity deprivation
ID:
状态:: 发布时间Oct. 25, 2008 , 更新时间 June 10, 2011 , 提交时间 June 9, 2008,
物种:: Mus musculus
摘要:: We analyzed whether cochlear removal-induced transcriptional changes in the cochlear nucleus (CN) were due to loss of electrical activity in the 8th nerve. Pharmacological activity blockade of the auditory nerve for 24 h resulted in similar expression changes for only a subset of genes. Thus, an additional factor not dependent on action potential-mediated signaling must also regulate transcriptional responses to deafferentation in the CN. Experiment Overall Design: TTX was infused into the cochlea unilaterally via osmotic pumps to block activity in the 8th nerve. CN tissue was dissected out from 10-12 mice per replicate and pooled. Three biological replicates were performed. Gene expression was compared between the ipsilateral and contralateral CN tissue to identify genes transcriptionally regulated after activity deprivation.
实验种类:: transcription profiling by array
样本量:: 6
实验设计:
: 无设计数据
数据号:: E-GEOD-11726, GSE11726
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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