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This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein acts as a transcriptional regulator when present in a complex with other proteins. It can activate p53 transcription to promote tumor cell apoptosis in lung cancer. The protein may be involved in the differentiation of developing male germ cells. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Apr 2015]
[中文简述(自动翻译):]  该基因编码的萨班斯法案的成员(SRY相关HMG盒)家族参与胚胎发育的调节,并在细胞命运的决心转录因子。所编码的蛋白质充当转??录调节存在于与其它蛋白复合时。它可以激活p53的转录促进肿瘤细胞凋亡的肺癌。该蛋白可能参与显影雄性生殖细胞的分化。这个基因的选择性剪接的结果在多个转录变体。一个相关的假基因已被确定在[由RefSeq的,2015年4月提供] 5号染色体
SOX30基因(以及对应的蛋白质)的细胞分布位置:
SOX30基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
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