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This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
[中文简述(自动翻译):]  该基因编码的胰岛素样生长因子2的mRNA结合蛋白家族中的一员。由该基因编码的蛋白质中含有4门K同源结构域和两个RNA识别基序。它的功能通过结合到某些基因,包括胰岛素样生长因子2,β-肌动蛋白和β-转导含重复蛋白的mRNA的,并调节它们的翻译。已发现该基因编码不同亚型的两个转录变异体。 [由RefSeq的,2009年5月提供]
IGF2BP1基因(以及对应的蛋白质)的细胞分布位置:
IGF2BP1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| melanoma | 0.003810118 | 4 | 0 | BeFree_LHGDN |
| Mammary Neoplasms | 0.003538676 | 3 | 0 | BeFree_LHGDN |
| Meningioma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Lung Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Lymphoma | 0.00272435 | 1 | 0 | LHGDN |
| ovarian neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.002638474 | 1 | 4 | BeFree_GAD |
| Atherosclerosis | 0.002367032 | 1 | 0 | GAD |
| Head and Neck Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
| Obesity | 0.002367032 | 1 | 0 | GAD |
| Neoplasms, Second Primary | 0.002367032 | 1 | 0 | GAD |
| Metabolic Syndrome X | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of breast | 0.001357209 | 5 | 0 | BeFree |
| Breast Carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Neoplasm Metastasis | 0.000814326 | 3 | 0 | BeFree |
| Metastatic melanoma | 0.000542884 | 2 | 0 | BeFree |
| Sarcoma | 0.000542884 | 2 | 0 | BeFree |
| Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Acidosis, Lactic | 0.000271442 | 1 | 0 | BeFree |
| Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Choriocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Toxoplasmosis | 0.000271442 | 1 | 0 | BeFree |
| Neoplasms, Neuroepithelial | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
| aggressive cancer | 0.000271442 | 1 | 0 | BeFree |
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