MYCN(v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

2p24.3
基因染色体位置图

基因简述

基因简述

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

[中文简述(自动翻译):]  此基因是Myc家族的成员，并且编码蛋白质与碱性螺旋 - 环 - 螺旋（bHLH）结构域。该蛋白位于细胞核内，并且必须以结合DNA与另一个的bHLH蛋白质二聚化。该基因的扩增与多种肿瘤相关的，最显着的神经母细胞瘤。已发现该基因编码不同亚型多重选择性剪接转录变异体。 [由RefSeq的，2014年6月提供]

OMIM数据库中对MYCN基因的介绍     Wikipedia数据库中对MYCN基因的介绍

基因序列

基因序列

MYCN基因的碱基序列：[NCBI]

基因突变

基因突变

MYCN基因的碱基突变：           显示全部snp
rs9653226       rs11886063       rs13034994       rs35648249       rs41264197       rs41264199       rs41295950       rs57961569       rs61613914       rs74848979       rs75731159       rs78264801       rs79884090       rs111360717       rs111645698       rs111866702       rs112433036       rs113865528       rs114130900       rs114926520       rs117839276       rs138991087       rs140479872       rs140724290       rs141190704       rs141260022       rs142571052       rs143746626       rs144428401       rs145287167       rs147651429       rs148146463       rs148277324       rs148975024       rs149276070       rs150434774       rs151113760      
rs181162426       rs183754206       rs184046450       rs185219172       rs185713214       rs186146246       rs186842177       rs188129461       rs190044705       rs190595163       rs190618915       rs191307751       rs192201711       rs199929021       rs200161041       rs200347061       rs201009439       rs368454159       rs370558211       rs371517719       rs373683425       rs374745691       rs377288993       rs377590323       rs528719242       rs529677821       rs529679125       rs530603465       rs532120788       rs532287757       rs532543210       rs532583361       rs532706006       rs534034023       rs534043077       rs534319674       rs534378915       rs534922699       rs536282076       rs536645837       rs536869114       rs537246153       rs537702090       rs537712766       rs538637715       rs538653043       rs538700586       rs540090021       rs540420976       rs540459919       rs540489428       rs541058718       rs541530338       rs541917011       rs542879110       rs544025593       rs544298881       rs544876355       rs544897028       rs545036529       rs546379275       rs547906514       rs548361248       rs548667786       rs549417123       rs550644511       rs550706958       rs550938636       rs551036120       rs551272858       rs552652009       rs552971645       rs554826136       rs555560106       rs556128837       rs557796876       rs558508426       rs559283976       rs560604976       rs561038774       rs561089452       rs563257368       rs564967633       rs565231959       rs565268371       rs566883495       rs567383021       rs567820123       rs567899538       rs568187046       rs568982792       rs569277484       rs569322990       rs569527205       rs570356159       rs570751336       rs570788097       rs571398665       rs571479830       rs571515951       rs571691834       rs572974255       rs573100118       rs573377492       rs574127083       rs574164955       rs574471856       rs574496150       rs574696960       rs575551772       rs576672292       rs577079213       rs745414155       rs745570906       rs746755569       rs746805841       rs747413221       rs747547602       rs747568578       rs747975237       rs748132825       rs748156396       rs748260335       rs748728413       rs748734356       rs748818541       rs749416324       rs749881307       rs750472300       rs750579922       rs750717149       rs751231470       rs751463329       rs751789215       rs751900208       rs751918450       rs752749374       rs753031171       rs753047771       rs753614852       rs753631213       rs754314632       rs754398747       rs754768625       rs754869267       rs755369959       rs755400695       rs755925852       rs756249997       rs756439436       rs756590478       rs756739797       rs756825638       rs757126575       rs757224277       rs757360369       rs757371872       rs757855020       rs758020996       rs758657333       rs758697983       rs759320806       rs759339159       rs759545096       rs759788436       rs759997149       rs760258394       rs760278391       rs760707911       rs760848356       rs761085679       rs761787091       rs762179216       rs762639151       rs763123842       rs763142340       rs763298242       rs763755133       rs764416757       rs764655512       rs764741267       rs764975322       rs765757312       rs766296336       rs766612774       rs767373881       rs767463815       rs767651526       rs767711936       rs767962049       rs768097049       rs768404232       rs768583620       rs768759295       rs768899655       rs769152073       rs769240539       rs769401203       rs769793821       rs769881620       rs769956590       rs770512842       rs771733797       rs771914958       rs772099565       rs772399455       rs772555630       rs772714029       rs772981756       rs773995882       rs774081987       rs774520005       rs774681603       rs775268500       rs775315003       rs775640153       rs775758169       rs776147637       rs776400798       rs776698783       rs776717109       rs776932880       rs777292565       rs777589913       rs777857794       rs777870812       rs778436138       rs778525839       rs778909224       rs779000620       rs779206813       rs779590223       rs779755745       rs780064642       rs780080562       rs780448923       rs780606114       rs781092541       rs781535490       rs922       rs15260       rs3755134       rs3755135       rs4669017       rs6741575       rs41264201       rs56337966       rs60226897       rs73212252       rs75913210       rs79223268       rs79703814       rs112085458       rs112435141       rs115776793       rs137893042       rs138606824       rs140276895       rs140567920       rs140581169       rs141300189       rs141392135       rs142866857       rs143438192       rs144531796       rs144532405       rs144648016       rs144939456       rs147140963       rs148464851       rs150023769       rs150742977       rs182386584       rs182733787       rs184691461       rs185639773       rs187710764       rs190053841       rs191864211       rs193218230       rs200236475       rs200482512       rs201114632       rs201115523       rs367962377       rs368599343       rs370751156       rs371743627       rs372079635       rs373326503       rs373661257       rs374105854       rs374300561       rs527827869       rs529144062       rs529269709       rs531585587       rs532977642       rs534637762       rs535284909       rs535673814       rs536110961       rs537281870       rs539035835       rs539097034       rs539739508       rs540091953       rs541057129       rs542437338       rs543842949       rs544306079       rs544553494       rs544663184       rs545262434       rs546284501       rs546447876       rs546658641       rs547226966       rs547291144       rs552715361       rs552910871       rs553427527       rs554483463       rs554520137       rs555381582       rs555597087       rs556559944       rs556854604       rs557289286       rs557453685       rs557967861       rs558288322       rs559222525       rs559259288       rs560565532       rs560993420       rs562066563       rs562873900       rs563066464       rs563214548       rs564603881       rs567160550       rs567217311       rs569763361       rs570195372       rs571025958       rs571270203       rs571853071       rs572661091       rs573844547       rs574376806       rs577556715       rs577620098       rs577928262       rs745701466       rs746256291       rs746515680       rs747134309       rs747603773       rs747637579       rs748246058       rs749231714       rs749269364       rs749608913       rs750750877       rs751108330       rs751553239       rs751904867       rs752454441       rs752702966       rs753519523       rs753699979       rs754137452       rs754536347       rs755033523       rs755948961       rs756266477       rs756989401       rs757095247       rs757452061       rs758901107       rs759103701       rs759475462       rs760276350       rs760647298       rs761502958       rs761805254       rs762164859       rs762439508       rs762737885       rs763325329       rs763830786       rs765130807       rs765770492       rs765859316       rs766297977       rs766312745       rs766929243       rs767377492       rs768023672       rs768128271       rs768274496       rs768809718       rs768951879       rs770204326       rs770760003       rs770817606       rs771271810       rs771601541       rs772161530       rs772649128       rs772736778       rs772930728       rs773438754       rs774239290       rs774985441       rs775092426       rs776128676       rs776413368       rs776847158       rs777089361       rs777508469       rs777840849       rs778058790       rs778923558       rs779292035       rs779379966       rs779959007       rs780694264       rs780712669       rs780717638       rs781383863       rs781551930      

基因表达

基因表达

MYCN基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CAGATGATGAAGATGATGAAGAGG
59
GATGGTGAATGTGGTGACAG
59
CAGATGATGAAGATGATGAAGAGG
59
ATGGTGAATGTGGTGACAG
58
CAGATGATGAAGATGATGAAGAGG
59
TGATGGTGAATGTGGTGAC
58

转录因子

转录因子

转录因子
影响类型
PubMed链接
ABCB1
Repression
7923112
ABCC1
Activation
10348353     14737110     7923112    
ABCC1
Unknown
9516823
BAX
Activation
19885598
BIRC5
Activation
22703967
BMI1
Activation
21856782
CD44
Activation
19885598
CDKN1A
Activation
19885598
CDKN1B
Unknown
16618721
CIITA
Repression
12107114

基因本体信息

MYCN基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

MYCN基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000785
P04198(UniProtKB)
TAS
GO:0001502
P04198(UniProtKB)
IEA
GO:0002053
P04198(UniProtKB)
IEA
GO:0003677
P04198(UniProtKB)
TAS
GO:0003700
P04198(UniProtKB)
IEA
GO:0005515
P04198(UniProtKB)
IPI
GO:0005515
P04198(UniProtKB)
IPI
GO:0005515
P04198(UniProtKB)
IPI
GO:0005515
P04198(UniProtKB)
IPI
GO:0005515
P04198(UniProtKB)
IPI
GO:0005515
P04198(UniProtKB)
IPI
GO:0005515
P04198(UniProtKB)
IPI
GO:0005515
P04198(UniProtKB)
IPI
GO:0005515
P04198(UniProtKB)
IPI
GO:0005515
P04198(UniProtKB)
IPI
GO:0005515
P04198(UniProtKB)
IPI
GO:0005515
P04198(UniProtKB)
IPI
GO:0005515
P04198(UniProtKB)
IPI
GO:0005515
P04198(UniProtKB)
IPI
GO:0005634
P04198(UniProtKB)
IDA
GO:0006351
P04198(UniProtKB)
IEA
GO:0006357
P04198(UniProtKB)
TAS
GO:0010628
P04198(UniProtKB)
IDA
GO:0010942
P04198(UniProtKB)
IEA
GO:0030324
P04198(UniProtKB)
IEA
GO:0042733
P04198(UniProtKB)
IEA
GO:0045607
P04198(UniProtKB)
IEA
GO:0045893
P04198(UniProtKB)
IMP
GO:0045944
P04198(UniProtKB)
IEA
GO:0046983
P04198(UniProtKB)
IEA
GO:0048704
P04198(UniProtKB)
IEA
GO:0048712
P04198(UniProtKB)
IEA
GO:0048754
P04198(UniProtKB)
IEA
GO:2000378
P04198(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控MYCN基因的相关microRNA：      显示全部miRNA

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Oculodigitoesophagoduodenal syndrome 0.481357209 7 6 BeFree_CLINVAR_CTD_human_ORPHANET_UNIPROT
Neuroblastoma 0.333621751 708 2 BeFree_CTD_human_LHGDN_ORPHANET
Medulloblastoma 0.129510397 26 0 BeFree_CTD_human_LHGDN
Neoplastic Cell Transformation 0.12 1 0 CTD_human
Chromosome Aberrations 0.12 1 0 CTD_human
Adenoid Cystic Carcinoma 0.12 1 0 CTD_human
Hyperplasia 0.12 1 0 CTD_human
Necrosis 0.12 1 0 CTD_human
Neural crest tumor 0.12 0 0 ORPHANET
Central neuroblastoma 0.08 610 2 BeFree
Carcinogenesis 0.010043349 37 1 BeFree
Retinoblastoma 0.008967513 23 0 BeFree_LHGDN
Neoplasm Metastasis 0.006514605 24 0 BeFree
Disseminated neuroblastoma 0.006514605 24 0 BeFree
Tumor Progression 0.005700279 21 0 BeFree
Nephroblastoma 0.005081451 10 0 BeFree_GAD
Lymphoma 0.00408156 5 0 BeFree_LHGDN
Stage 4S neuroblastoma 0.003800186 14 0 BeFree
Brain Neoplasms 0.003267234 2 0 BeFree_LHGDN
leukemia 0.003267234 3 0 BeFree_LHGDN
Neoplasm, Residual 0.003267234 2 0 BeFree_LHGDN
Sarcoma 0.003267234 2 0 BeFree_LHGDN
synovial sarcoma 0.002995792 1 0 BeFree_LHGDN
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 0.002995792 1 0 BeFree_LHGDN
Neurocytoma 0.002995792 1 0 BeFree_LHGDN
Congenital chromosomal disease 0.002985861 11 0 BeFree
Basal cell carcinoma 0.00272435 1 0 LHGDN
Small cell carcinoma of lung 0.002714419 10 0 BeFree
Malignant Childhood Neoplasm 0.002714419 10 0 BeFree
Rhabdomyosarcoma 0.002442977 9 0 BeFree
Ganglioneuroblastoma 0.002442977 9 0 BeFree
Kidney Neoplasm 0.002367032 1 0 GAD
Ganglioneuroma 0.002171535 8 0 BeFree
Alveolar rhabdomyosarcoma 0.001628651 6 0 BeFree
stage, neuroblastoma 0.001628651 6 0 BeFree
Glioblastoma 0.001357209 5 0 BeFree
Neuroectodermal Tumor, Primitive 0.001357209 5 0 BeFree
Malignant neoplasm of lung 0.001357209 5 0 BeFree
Liver carcinoma 0.001357209 5 0 BeFree
Colorectal Carcinoma 0.001085767 4 0 BeFree
Neuroectodermal Tumors 0.001085767 4 0 BeFree
Triploidy syndrome 0.001085767 4 0 BeFree
Malignant neoplasm of prostate 0.001085767 4 2 BeFree
Prostate carcinoma 0.001085767 4 2 BeFree
Colorectal Cancer 0.001085767 4 0 BeFree
Trisomy 0.000814326 3 0 BeFree
Rhabdomyosarcoma, Embryonal 0.000814326 3 0 BeFree
Isochromosomes 0.000814326 3 0 BeFree
Extraosseous Ewings sarcoma-primitive neuroepithelial tumor 0.000814326 3 0 BeFree
Solid tumour 0.000814326 3 0 BeFree
Neuroblastic Tumor 0.000814326 3 0 BeFree
Adenocarcinoma 0.000542884 2 0 BeFree
Anaplasia 0.000542884 2 0 BeFree
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Chronic Lymphocytic Leukemia 0.000542884 2 0 BeFree
Leukemia, Myelocytic, Acute 0.000542884 2 0 BeFree
Liver neoplasms 0.000542884 2 0 BeFree
melanoma 0.000542884 2 0 BeFree
Microcephaly 0.000542884 2 0 BeFree
Embryonal Neoplasm 0.000542884 2 0 BeFree
Neuroendocrine Tumors 0.000542884 2 0 BeFree
Cervix carcinoma 0.000542884 2 0 BeFree
Progressive Neoplastic Disease 0.000542884 2 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Carcinoma of lung 0.000542884 2 0 BeFree
Ewings sarcoma-primitive neuroectodermal tumor (PNET) 0.000542884 2 0 BeFree
Chromosome 1, monosomy 1p 0.000542884 2 0 BeFree
Precursor B-cell lymphoblastic leukemia 0.000542884 2 0 BeFree
Supratentorial Primitive Neuroectodermal Tumor 0.000542884 2 0 BeFree
Ganglioneuroblastoma, Nodular 0.000542884 2 0 BeFree
Xenograft Model 0.000542884 2 0 BeFree
Progressive cGVHD 0.000542884 2 0 BeFree
Abdominal Neoplasms 0.000271442 1 0 BeFree
Adrenal Gland Neoplasms 0.000271442 1 0 BeFree
Rheumatoid Arthritis 0.000271442 1 0 BeFree
Malignant neoplasm of urinary bladder 0.000271442 1 0 BeFree
Malignant tumor of colon 0.000271442 1 0 BeFree
Malignant neoplasm of thyroid 0.000271442 1 0 BeFree
Non-Small Cell Lung Carcinoma 0.000271442 1 0 BeFree
Renal Cell Carcinoma 0.000271442 1 0 BeFree
Ependymoma 0.000271442 1 0 BeFree
Esophageal Atresia 0.000271442 1 0 BeFree
Exanthema 0.000271442 1 0 BeFree
Hepatitis 0.000271442 1 0 BeFree
Hepatitis A 0.000271442 1 0 BeFree
Lymphoid leukemia 0.000271442 1 0 BeFree
Acute Megakaryocytic Leukemias 0.000271442 1 0 BeFree
Malignant neoplasm of stomach 0.000271442 1 0 BeFree
Meningioma 0.000271442 1 0 BeFree
Mitral Valve Stenosis 0.000271442 1 0 BeFree
Multiple Sclerosis 0.000271442 1 0 BeFree
Nervous System Neoplasms 0.000271442 1 0 BeFree
Osteosarcoma 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Pheochromocytoma 0.000271442 1 0 BeFree
Temporomandibular Joint Dysfunction Syndrome 0.000271442 1 0 BeFree
Attention Deficit Disorder 0.000271442 1 0 BeFree
B-Cell Lymphomas 0.000271442 1 0 BeFree
Severe Combined Immunodeficiency 0.000271442 1 0 BeFree
Central Nervous System Neoplasms 0.000271442 1 0 BeFree
Malignant neoplasm of testis 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lung 0.000271442 1 0 BeFree
pineoblastoma 0.000271442 1 0 BeFree
Carcinoma, Neuroendocrine 0.000271442 1 0 BeFree
Central Neurocytoma 0.000271442 1 0 BeFree
Gastrointestinal Stromal Tumors 0.000271442 1 0 BeFree
Medullary carcinoma of thyroid 0.000271442 1 0 BeFree
Spastic syndrome 0.000271442 1 0 BeFree
Malignant neoplasm of colon stage IV 0.000271442 1 0 BeFree
Medulloblastoma, Childhood 0.000271442 1 0 BeFree
Gastric Adenocarcinoma 0.000271442 1 0 BeFree
childhood solid tumor 0.000271442 1 0 BeFree
childhood synovial sarcoma 0.000271442 1 0 BeFree
Anaplastic astrocytoma 0.000271442 1 0 BeFree
Retinoma 0.000271442 1 0 BeFree
Opsoclonus-Myoclonus Syndrome 0.000271442 1 0 BeFree
Thyroid carcinoma 0.000271442 1 0 BeFree
Ewings sarcoma 0.000271442 1 0 BeFree
Malignant Glioma 0.000271442 1 0 BeFree
Tumor Initiation 0.000271442 1 0 BeFree
CNS metastases 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lymph node 0.000271442 1 0 BeFree
Stomach Carcinoma 0.000271442 1 0 BeFree
Carcinoma of bladder 0.000271442 1 0 BeFree
Dissecting aneurysm of the thoracic aorta 0.000271442 1 0 BeFree
Malignant neoplasm of kidney 0.000271442 1 0 BeFree
Adult Acute Lymphocytic Leukemia 0.000271442 1 0 BeFree
Malignant Peripheral Nerve Sheath Tumor 0.000271442 1 0 BeFree
Chromosome 10, monosomy 10q 0.000271442 1 0 BeFree
Localized Malignant Neoplasm 0.000271442 1 0 BeFree
Spots on skin 0.000271442 1 0 BeFree
Advanced cancer 0.000271442 1 0 BeFree
precancerous lesions 0.000271442 1 0 BeFree
Malignant neoplasm of ovary 0.000271442 1 0 BeFree
Attention deficit hyperactivity disorder 0.000271442 1 0 BeFree
Atypical teratoid/rhabdoid tumor 0.000271442 1 0 BeFree
Retinoblastoma, spontaneously regressed 0.000271442 1 0 BeFree
Anaplastic large B-cell lymphoma 0.000271442 1 0 BeFree
Localized Carcinoma 0.000271442 1 0 BeFree
Stage 3 Neuroblastoma 0.000271442 1 0 BeFree
Testicular Germ Cell Tumor 0.000271442 1 0 BeFree
Renal carcinoma 0.000271442 1 0 BeFree
Desmoplastic 0.000271442 1 0 BeFree
Differentiating Neuroblastoma 0.000271442 1 0 BeFree
Poorly Differentiated Neuroblastoma 0.000271442 1 0 BeFree
Ganglioneuroblastoma, Intermixed 0.000271442 1 0 BeFree
Meningioma, benign, no ICD-O subtype 0.000271442 1 0 BeFree
TIBIAL MUSCULAR DYSTROPHY, TARDIVE 0.000271442 1 0 BeFree
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 0.000271442 1 0 BeFree
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor 0.000271442 1 0 BeFree

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