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The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是I型膜形成为干扰素α和β受体的两条链中的一个蛋白。结合和受体活化刺激的Janus蛋白质激酶,这反过来又磷酸化几种蛋白质,包括STAT1和STAT2。多个转录变体在至少两个不同的同种型已发现此基因编码。 [由RefSeq的,2008年7月提供]
IFNAR2基因(以及对应的蛋白质)的细胞分布位置:
IFNAR2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hepatitis B | 0.120814326 | 3 | 0 | BeFree_CTD_human |
Down Syndrome | 0.12 | 1 | 0 | CTD_human |
Muscle Weakness | 0.12 | 1 | 0 | CTD_human |
HEPATITIS B VIRUS, SUSCEPTIBILITY TO | 0.12 | 0 | 1 | CLINVAR |
Malignant neoplasm of lung | 0.009468128 | 4 | 0 | GAD |
Hepatitis C | 0.008544182 | 7 | 0 | BeFree_GAD_LHGDN |
Liver carcinoma | 0.008087174 | 4 | 0 | BeFree_GAD_LHGDN |
Hepatitis C, Chronic | 0.007915422 | 6 | 0 | BeFree_GAD |
Renal Cell Carcinoma | 0.005991584 | 3 | 0 | BeFree_LHGDN |
Multiple Sclerosis | 0.005276948 | 3 | 0 | BeFree_GAD |
Bronchiolitis, Viral | 0.004734064 | 2 | 0 | GAD |
Respiratory Syncytial Virus Infections | 0.004734064 | 2 | 0 | GAD |
Neoplasm Metastasis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Liver Cirrhosis | 0.002909916 | 3 | 0 | BeFree_GAD |
Burkitt Lymphoma | 0.00272435 | 1 | 0 | LHGDN |
Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Severe Combined Immunodeficiency | 0.00272435 | 1 | 0 | LHGDN |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Measles | 0.002638474 | 2 | 0 | BeFree_GAD |
Rubella | 0.002638474 | 2 | 0 | BeFree_GAD |
Hepatitis B, Chronic | 0.002638474 | 2 | 0 | BeFree_GAD |
Asthma | 0.002367032 | 1 | 0 | GAD |
Atherosclerosis | 0.002367032 | 1 | 0 | GAD |
Behcet Syndrome | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
Myeloid Leukemia | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Mumps | 0.002367032 | 1 | 0 | GAD |
Neutropenia | 0.002367032 | 1 | 0 | GAD |
Thrombocytopenia | 0.002367032 | 1 | 0 | GAD |
Respiratory syncytial virus bronchiolitis | 0.002367032 | 1 | 0 | GAD |
Multiple Sclerosis, Relapsing-Remitting | 0.002367032 | 1 | 0 | GAD |
Virus Diseases | 0.000814326 | 3 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000542884 | 2 | 0 | BeFree |
Lymphopenia | 0.000271442 | 1 | 0 | BeFree |
Mitral Valve Stenosis | 0.000271442 | 1 | 0 | BeFree |
Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Cervical intraepithelial neoplasia grade 1 | 0.000271442 | 1 | 0 | BeFree |
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