GPS2(G protein pathway suppressor 2)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

17p13.1
基因染色体位置图

基因简述

基因简述

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  这个基因编码的信号通路参与G蛋白丝裂原活化蛋白激酶（MAPK）的蛋白质。当在哺乳动物细胞中过度表达，这种基因可以有力地抑制RAS-和MAPK介导的信号，并与JNK活性干扰，这表明该基因的功能可以是信号压制。所编码的蛋白质是NCOR1-HDAC3的组成亚基（核受体辅抑制子1组蛋白脱乙酰酶3）配合物，并且它表明该络合物通过这个亚基抑制JNK活化并因此有可能提供一种激素介导的拮抗作用的替代机制AP1的（激活蛋白1）的功能。 [由RefSeq的，2008年7月提供]

OMIM数据库中对GPS2基因的介绍     Wikipedia数据库中对GPS2基因的介绍

基因序列

基因序列

GPS2基因的碱基序列：[NCBI]

基因突变

基因突变

GPS2基因的碱基突变：           显示全部snp
rs1054335       rs1054378       rs1054414       rs2292065       rs8075575       rs73239595       rs111733461       rs113357467       rs113440274       rs116037975       rs117056964       rs142252898       rs142399692       rs147653865       rs150864485       rs189530109       rs199805281       rs202227992       rs368238101       rs370769252       rs372323898       rs373554798       rs374342877       rs374842419       rs376182174       rs376284181       rs528614610       rs530034214       rs530813232       rs530877542       rs535340152       rs536128788       rs538040242       rs538837723       rs542930712       rs546566889       rs550583389      
rs552362278       rs554236502       rs559666946       rs564979092       rs566531799       rs566702745       rs567565322       rs574300589       rs745403587       rs746803379       rs747136071       rs748581349       rs749165624       rs749859598       rs750891444       rs751015934       rs751087836       rs751162059       rs753053885       rs754267121       rs754392019       rs754550645       rs756408852       rs756600341       rs757816191       rs758022867       rs759555319       rs759684956       rs761024211       rs761810474       rs762194404       rs762371964       rs764351211       rs764963042       rs765753130       rs765869813       rs766436965       rs767661678       rs767681373       rs768907158       rs769003405       rs769667385       rs770259226       rs770273163       rs770914570       rs772040196       rs773759090       rs774371895       rs774431238       rs775542447       rs776473038       rs776964709       rs777089307       rs777611124       rs777660501       rs778162432       rs778631531       rs779551423       rs779930323       rs780901898       rs8610       rs870892       rs1043779       rs1043786       rs1043790       rs1043791       rs1043792       rs2270981       rs2279818       rs2292064       rs3215130       rs6503013       rs7219974       rs8072397       rs8075515       rs8076120       rs11541828       rs11541829       rs57589460       rs62059197       rs73239597       rs73977634       rs73977635       rs73977636       rs77956194       rs78173576       rs79754089       rs80305658       rs111653727       rs111869029       rs112435041       rs112452916       rs113167184       rs113385637       rs115083985       rs117189746       rs117946740       rs139574677       rs139664491       rs140627974       rs141142642       rs141194990       rs141649936       rs142228539       rs142288970       rs143526087       rs144209448       rs145613623       rs145791776       rs146023090       rs146538110       rs147815838       rs147873069       rs147983205       rs148743274       rs149405554       rs149591136       rs149753852       rs181425435       rs182840816       rs184661596       rs186032429       rs186566745       rs187063706       rs188636403       rs188999601       rs190993180       rs192050225       rs199616764       rs199712212       rs199799769       rs199845896       rs200001346       rs200170373       rs200211892       rs200523158       rs200620818       rs200755120       rs200788414       rs200928306       rs201061613       rs201160537       rs201162324       rs201297310       rs201366443       rs201534195       rs201535834       rs201538451       rs201607175       rs201630551       rs201950027       rs202014225       rs202127770       rs202134408       rs202158879       rs368269424       rs368474329       rs368529019       rs368548699       rs369034320       rs369184510       rs369293222       rs369394948       rs370155476       rs370215902       rs370397176       rs370708649       rs370780819       rs371133988       rs371218282       rs371318711       rs371627794       rs371642641       rs371841461       rs371975754       rs372039533       rs372607972       rs372762077       rs373002868       rs373549717       rs373622628       rs373938682       rs374044574       rs374085583       rs374150941       rs374276970       rs374324699       rs374633373       rs374651452       rs374699021       rs374767805       rs374937018       rs375006052       rs375177262       rs375271864       rs375408699       rs375455317       rs376056940       rs376328573       rs376374058       rs376755491       rs376877305       rs376937003       rs377084325       rs377341598       rs377373738       rs377513078       rs528877999       rs529340648       rs529424161       rs531403680       rs532828296       rs533503892       rs534281043       rs535851721       rs535946078       rs536920923       rs537263656       rs537436001       rs539852697       rs539917505       rs540779239       rs540842172       rs542088936       rs542214850       rs543099336       rs544736203       rs546456223       rs548034577       rs549200449       rs549384918       rs549389257       rs551324054       rs553042666       rs554581003       rs554767454       rs555154090       rs555441444       rs555638284       rs556565092       rs556847181       rs557500447       rs558760567       rs558802048       rs559059220       rs560198132       rs561771120       rs562714059       rs562774644       rs563178073       rs563273312       rs563708524       rs563819116       rs564713759       rs564776937       rs565657688       rs565723257       rs566844220       rs568610925       rs568624710       rs568991676       rs569464551       rs570001593       rs570021392       rs570686624       rs570975471       rs571040715       rs571161683       rs571226312       rs572199025       rs573616466       rs576285160       rs577300373       rs577367557       rs577399830       rs577406842       rs745573956       rs745671551       rs745728690       rs745833183       rs745980232       rs746024129       rs746263209       rs746318470       rs746382647       rs746443109       rs746446577       rs746478678       rs746601137       rs746831445       rs746882992       rs747006852       rs747167941       rs747170120       rs747205747       rs747355959       rs747493645       rs747581834       rs747617851       rs747637318       rs747733650       rs747858118       rs747919781       rs748017048       rs748103740       rs748273783       rs748326636       rs748648209       rs748734044       rs748835899       rs748888937       rs749038830       rs749072964       rs749225670       rs749508687       rs749689174       rs749692903       rs749730692       rs749732211       rs749849998       rs749873385       rs749986238       rs750009735       rs750108379       rs750250498       rs750374798       rs750424002       rs750554612       rs750631519       rs750683832       rs750692300       rs750817188       rs750819667       rs751006852       rs751090965       rs751173137       rs751195748       rs751250737       rs751534351       rs751710747       rs751763715       rs751860704       rs751903007       rs751951805       rs752178305       rs752327546       rs752469217       rs752523293       rs752624973       rs752747060       rs752902884       rs753107167       rs753127153       rs753579625       rs753674388       rs753866859       rs753869459       rs754075904       rs754102368       rs754228666       rs754391867       rs754444805       rs754631983       rs754634220       rs754766975       rs754814088       rs755102164       rs755106235       rs755133519       rs755157162       rs755187284       rs755269537       rs755466716       rs755684619       rs755684835       rs755818868       rs755820287       rs756013916       rs756183635       rs756358952       rs756454420       rs756537306       rs756698225       rs756811014       rs756918890       rs756940614       rs757139280       rs757221166       rs757349251       rs757458525       rs757616701       rs757671243       rs757671852       rs757836310       rs758044036       rs758175051       rs758427184       rs758549735       rs758758785       rs758974090       rs759020590       rs759028513       rs759127635       rs759368793       rs759447194       rs759448795       rs759579428       rs759606658       rs759663710       rs759918169       rs760199929       rs760253219       rs760303804       rs760356712       rs760488877       rs760595305       rs760717993       rs760722898       rs760841800       rs761006542       rs761096798       rs761700279       rs761793531       rs761844941       rs762160750       rs762187704       rs762414201       rs762468194       rs762497187       rs762540705       rs762822597       rs762940203       rs762946566       rs763123403       rs763222074       rs763248247       rs763275059       rs763306643       rs763539198       rs763632313       rs763838649       rs763892022       rs764000492       rs764101033       rs764282272       rs764303771       rs764404941       rs764591627       rs764686791       rs764710703       rs764718125       rs764921529       rs765011305       rs765026290       rs765243418       rs765243488       rs765288198       rs765368632       rs765467683       rs765693152       rs765989189       rs766035428       rs766121712       rs766446270       rs766525016       rs766613352       rs766666420       rs766822954       rs766877960       rs766945384       rs766997759       rs767051134       rs767145433       rs767237004       rs767277141       rs767280768       rs767563056       rs767600161       rs767691634       rs767712635       rs768065711       rs768093113       rs768201125       rs768215762       rs768252271       rs768443815       rs768492189       rs768497141       rs768561673       rs768613610       rs768791304       rs768943484       rs769049828       rs769128301       rs769278587       rs769364819       rs769415573       rs769596863       rs769651838       rs769775517       rs769805611       rs769918037       rs769928378       rs770092574       rs770096094       rs770148413       rs770178610       rs770373693       rs770804109       rs770906120       rs770926795       rs771202809       rs771319368       rs771463336       rs771648068       rs771652550       rs771751850       rs771904779       rs771950826       rs772091319       rs772367743       rs772401855       rs772455386       rs772518884       rs772570395       rs772738044       rs773088924       rs773097026       rs773237258       rs773286418       rs773345677       rs773412928       rs773643640       rs773682607       rs773762692       rs773857574       rs773982297       rs774154272       rs774154591       rs774207980       rs774399124       rs774436733       rs774494745       rs774498715       rs774631800       rs774633910       rs774886900       rs774941580       rs774992864       rs775258861       rs775259683       rs775674361       rs775712325       rs775804583       rs775822680       rs775945486       rs776020268       rs776129489       rs776342956       rs776393081       rs776495886       rs776596910       rs776644362       rs776697746       rs776698423       rs776721818       rs776822081       rs777054220       rs777140504       rs777385291       rs777479936       rs777662922       rs778030372       rs778121207       rs778141825       rs778163298       rs778225785       rs778245956       rs778534546       rs778551535       rs778784405       rs778814855       rs778888685       rs779309463       rs779381134       rs779522486       rs779577464       rs779630813       rs779674862       rs779913287       rs780242130       rs780293484       rs780340312       rs780454570       rs780507816       rs780571884       rs780715806       rs780806259       rs780859859       rs780984154       rs781026840       rs781041326       rs781079899       rs781149049       rs781356479       rs781481038      

基因表达

基因表达

GPS2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GCTTCTCCGACTCATCCTC
60
CACTTGTGGTAGAATCGCG
59
TTCTCCGACTCATCCTCTC
58
TCACTTGTGGTAGAATCGC
58
AAGGAACAGAGTGACCTGAC
59
TGAGGAGATGAGTTCCTGTG
59
AGTGCAGTACCTATCTCAGC
59
CTGGAGGAAACCTGTCTGAG
60
AAGATGAAGGAAGAACAGGAG
57
CTTCAGAATTTGTTCCTTGGTC
58
CTTCTCCGACTCATCCTCTC
59
CACTTGTGGTAGAATCGCG
59
GTCTGGCAGTCAGAGACAG
60
CACCTCTTCTTCCTCCTGC
60
GTCTGGCAGTCAGAGACAG
60
TCCACCTCTTCTTCCTCCT
59
AGTGCAGTACCTATCTCAGC
59
CTGGAGGAAACCTGTCTGAG
60
CTTCTCCGACTCATCCTCTC
59
CACTTGTGGTAGAATCGCG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

GPS2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

GPS2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000122
Q13227(UniProtKB)
IDA
GO:0000188
Q13227(UniProtKB)
TAS
GO:0003714
Q13227(UniProtKB)
IDA
GO:0005095
Q13227(UniProtKB)
TAS
GO:0005515
Q13227(UniProtKB)
IPI
GO:0005515
Q13227(UniProtKB)
IPI
GO:0005515
Q13227(UniProtKB)
IPI
GO:0005515
Q13227(UniProtKB)
IPI
GO:0005515
Q13227(UniProtKB)
IPI
GO:0005515
Q13227(UniProtKB)
IPI
GO:0005515
Q13227(UniProtKB)
IPI
GO:0005515
Q13227(UniProtKB)
IPI
GO:0005515
Q13227(UniProtKB)
IPI
GO:0005515
Q13227(UniProtKB)
IPI
GO:0005515
Q13227(UniProtKB)
IPI
GO:0005515
Q13227(UniProtKB)
IPI
GO:0005515
Q13227(UniProtKB)
IPI
GO:0005654
Q13227(UniProtKB)
TAS
GO:0007049
Q13227(UniProtKB)
TAS
GO:0007254
Q13227(UniProtKB)
TAS
GO:0017053
Q13227(UniProtKB)
IDA
GO:0034260
Q13227(UniProtKB)
IEA
GO:0046329
Q13227(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控GPS2基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Glioblastoma 0.000271442 1 0 BeFree
HIV Infections 0.000271442 1 0 BeFree
melanoma 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
Obesity, Morbid 0.000271442 1 0 BeFree
Sarcoma, Spindle Cell 0.000271442 1 0 BeFree
Hypoalbuminemia 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Glioblastoma Multiforme 0.000271442 1 0 BeFree

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