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This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
[中文简述(自动翻译):]  这个基因编码,调节造血Ⅲ类受体酪氨酸激酶。这种受体是通过对细胞外结构域,其诱导在质膜,导致受体的自磷酸化同二聚体形成FMS相关酪氨酸激酶3配体的结合而活化。活化的受体激酶随后磷酸化并在参与细胞凋亡,增殖,和在骨髓造血细胞的分化途径激活多种细胞质效应分子。导致在急性骨髓性白血病和急性淋巴细胞性白血病该受体结果的组成性活化的突变。 [由RefSeq的,2015年1月提供]
FLT3基因(以及对应的蛋白质)的细胞分布位置:
FLT3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Leukemia, Myelocytic, Acute | 0.56 | 707 | 10 | BeFree_CLINVAR_CTD_human_GAD_LHGDN_MGD |
Acute Promyelocytic Leukemia | 0.146588829 | 46 | 0 | BeFree_CTD_human_GAD_LHGDN |
Acute lymphocytic leukemia | 0.130314791 | 38 | 3 | BeFree_CLINVAR |
Acute biphenotypic leukemia | 0.12 | 0 | 0 | ORPHANET |
Thrombosis | 0.12 | 1 | 0 | CTD_human |
LEUKEMIA, ACUTE LYMPHOBLASTIC, SUSCEPTIBILITY TO, 3 | 0.12 | 0 | 0 | ORPHANET |
leukemia | 0.093278617 | 151 | 1 | BeFree_GAD_LHGDN |
Juvenile Myelomonocytic Leukemia | 0.080542884 | 2 | 0 | BeFree_MGD |
Arthritis, Experimental | 0.08 | 1 | 0 | RGD |
Myeloid Leukemia | 0.056970589 | 30 | 1 | BeFree_GAD_LHGDN |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.034228927 | 37 | 0 | BeFree_GAD_LHGDN |
MYELODYSPLASTIC SYNDROME | 0.026804189 | 22 | 0 | BeFree_GAD_LHGDN |
Preleukemia | 0.011715608 | 20 | 0 | BeFree_GAD |
Neoplasm, Residual | 0.011605987 | 24 | 0 | BeFree_GAD_LHGDN |
Acute leukemia | 0.010857675 | 40 | 0 | BeFree |
Leukemogenesis | 0.009229024 | 34 | 0 | BeFree |
Cytogenetically normal acute myeloid leukemia | 0.008143256 | 30 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.007991366 | 14 | 2 | BeFree_GAD |
pediatric acute myeloblastic leukemia | 0.007600372 | 28 | 0 | BeFree |
Adult Acute Myeloblastic Leukemia | 0.006514605 | 24 | 0 | BeFree |
Leukemia, Myelomonocytic, Chronic | 0.006091273 | 7 | 2 | BeFree_GAD |
Down Syndrome | 0.005362824 | 2 | 0 | BeFree_GAD_LHGDN |
Hematologic Neoplasms | 0.004895885 | 8 | 0 | BeFree_LHGDN |
Chromosome Aberrations | 0.004734064 | 2 | 0 | GAD |
Myeloproliferative disease | 0.00434307 | 16 | 0 | BeFree |
Lymphoid leukemia | 0.003452799 | 5 | 0 | BeFree_GAD |
MULTICYSTIC RENAL DYSPLASIA, BILATERAL | 0.003257302 | 12 | 0 | BeFree |
Leukocytosis | 0.00272435 | 1 | 0 | LHGDN |
Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
Neoplastic Cell Transformation | 0.002367032 | 1 | 0 | GAD |
Lymphoproliferative Disorders | 0.002367032 | 1 | 0 | GAD |
Pathologic Neovascularization | 0.002367032 | 1 | 0 | GAD |
Osteoporosis | 0.002367032 | 1 | 0 | GAD |
Pancreatic Neoplasm | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Chromosomal translocation | 0.002367032 | 1 | 0 | GAD |
XYY Karyotype | 0.002367032 | 1 | 0 | GAD |
Congenital chromosomal disease | 0.001628651 | 6 | 0 | BeFree |
Leukemia, Lymphocytic, Acute, L1 | 0.001628651 | 6 | 0 | BeFree |
Nephroblastoma | 0.001628651 | 6 | 0 | BeFree |
secondary acute myeloid leukemia | 0.001628651 | 6 | 0 | BeFree |
Acute monocytic leukemia | 0.001357209 | 5 | 0 | BeFree |
Hematopoietic Neoplasms | 0.001357209 | 5 | 0 | BeFree |
Neuroblastoma | 0.001085767 | 4 | 0 | BeFree |
Refractory cancer | 0.001085767 | 4 | 0 | BeFree |
Central neuroblastoma | 0.001085767 | 4 | 0 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.001085767 | 4 | 0 | BeFree |
Chronic myeloproliferative disorder | 0.001085767 | 4 | 0 | BeFree |
Hyperdiploid B Acute Lymphoblastic Leukemia | 0.001085767 | 4 | 0 | BeFree |
Monosomy | 0.000814326 | 3 | 0 | BeFree |
Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome | 0.000814326 | 3 | 0 | BeFree |
Core binding factor acute myeloid leukemia | 0.000814326 | 3 | 0 | BeFree |
Refractory anaemia with excess blasts | 0.000542884 | 2 | 0 | BeFree |
Autoimmune Diseases | 0.000542884 | 2 | 0 | BeFree |
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Myelodysplasia | 0.000542884 | 2 | 0 | BeFree |
Acute Myeloid Leukemia, M1 | 0.000542884 | 2 | 0 | BeFree |
Patau syndrome | 0.000542884 | 2 | 0 | BeFree |
Granulocytic Sarcoma | 0.000542884 | 2 | 0 | BeFree |
Mastocytosis, Systemic | 0.000542884 | 2 | 0 | BeFree |
Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
Miller Dieker syndrome | 0.000542884 | 2 | 0 | BeFree |
Refractory anemia with excess blasts in transformation (clinical) | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
Trisomy 11 | 0.000542884 | 2 | 0 | BeFree |
Chromosome 8, trisomy | 0.000542884 | 2 | 0 | BeFree |
Thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
M5b Acute differentiated monocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
Treatment related acute myeloid leukaemia | 0.000542884 | 2 | 0 | BeFree |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Promyelocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
Refractory anemias | 0.000271442 | 1 | 0 | BeFree |
Arthritis | 0.000271442 | 1 | 0 | BeFree |
Blast Phase | 0.000271442 | 1 | 0 | BeFree |
Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Dermatitis | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Eosinophilia | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Graft-vs-Host Disease | 0.000271442 | 1 | 0 | BeFree |
Hematological Disease | 0.000271442 | 1 | 0 | BeFree |
Herpes Simplex Infections | 0.000271442 | 1 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Hairy Cell Leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukopenia | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Neoplasms, Experimental | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Paraplegia | 0.000271442 | 1 | 0 | BeFree |
Polycythemia Vera | 0.000271442 | 1 | 2 | BeFree |
Psoriasis | 0.000271442 | 1 | 0 | BeFree |
Dermatologic disorders | 0.000271442 | 1 | 0 | BeFree |
Germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
Neuroectodermal Tumors | 0.000271442 | 1 | 0 | BeFree |
Neuroectodermal Tumor, Primitive | 0.000271442 | 1 | 0 | BeFree |
Trisomy 22 | 0.000271442 | 1 | 0 | BeFree |
relapsing chronic myelogenous leukemia | 0.000271442 | 1 | 0 | BeFree |
T-cell adult acute lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
childhood acute promyelocytic leukemia (M3) | 0.000271442 | 1 | 0 | BeFree |
Extraosseous Ewings sarcoma-primitive neuroepithelial tumor | 0.000271442 | 1 | 0 | BeFree |
Acute Undifferentiated Leukemia | 0.000271442 | 1 | 0 | BeFree |
Sarcoma of breast | 0.000271442 | 1 | 0 | BeFree |
Ewings sarcoma | 0.000271442 | 1 | 0 | BeFree |
Hypofibrinogenemia | 0.000271442 | 1 | 0 | BeFree |
Lymphoid neoplasm | 0.000271442 | 1 | 0 | BeFree |
Ewings sarcoma-primitive neuroectodermal tumor (PNET) | 0.000271442 | 1 | 0 | BeFree |
Hypereosinophilia | 0.000271442 | 1 | 0 | BeFree |
Adult Acute Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Myelosuppression | 0.000271442 | 1 | 0 | BeFree |
Rhabdoid Tumor of the Kidney | 0.000271442 | 1 | 0 | BeFree |
Neutrophilic dermatosis | 0.000271442 | 1 | 0 | BeFree |
Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Therapy-related myelodysplastic syndrome | 0.000271442 | 1 | 0 | BeFree |
Mast cell malignancy | 0.000271442 | 1 | 0 | BeFree |
Eosinophilic disorder | 0.000271442 | 1 | 0 | BeFree |
Undifferentiated leukemia | 0.000271442 | 1 | 0 | BeFree |
Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Chronic myeloid leukemia in lymphoid blast crisis | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
Disorder characterized by eosinophilia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, B-Cell | 0.000271442 | 1 | 0 | BeFree |
Extramedullary Hematopoiesis (disorder) | 0.000271442 | 1 | 0 | BeFree |
Acute Myeloid Leukemia with Myelodysplasia-Related Changes | 0.000271442 | 1 | 0 | BeFree |
Treatment related leukaemia | 0.000271442 | 1 | 0 | BeFree |
Acute myeloid leukemia with mutated CEBPA | 0.000271442 | 1 | 0 | BeFree |
Neural crest tumor | 0.000271442 | 1 | 0 | BeFree |
Refractory anemia, without ringed sideroblasts, without excess blasts | 0.000271442 | 1 | 0 | BeFree |
Intracranial glioma | 0.000271442 | 1 | 0 | BeFree |
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