SIRT6(sirtuin 6)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

19p13.3
基因染色体位置图

基因简述

基因简述

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

[中文简述(自动翻译):]  该基因编码的蛋白质的沉默调节蛋白家族中的一员，其同源酵母Sir2的蛋白质。沉默调节蛋白家族成员的特征在于沉默调节核心结构域和分组为四个类。人类沉默调节蛋白的功能尚未确定;然而，酵母蛋白质的sirtuin已知表观遗传调控基因沉默和压抑的rDNA重组。研究表明，人类可能乙酰化酶功能的单ADP核糖基转移酶的活性细胞内调控蛋白。由该基因编码的蛋白质包含在沉默调节蛋白家族的IV级。选择性剪接结果在多个抄本变形。[由RefSeq的，2010年7月提供]

OMIM数据库中对SIRT6基因的介绍     Wikipedia数据库中对SIRT6基因的介绍

基因序列

基因序列

SIRT6基因的碱基序列：[NCBI]

基因突变

基因突变

SIRT6基因的碱基突变：           显示全部snp
rs352493       rs3760905       rs3760906       rs3760907       rs3760908       rs4359565       rs4807546       rs7260071       rs34786277       rs55716500       rs57280997       rs57977086       rs62130860       rs73540079       rs73918060       rs73918061       rs75794183       rs111867062       rs112116785       rs113172228       rs114073648       rs114436993       rs114987740       rs115483609       rs117217081       rs138000255       rs138672417       rs138839184       rs140032024       rs141840031       rs142479523       rs143396713       rs145959288       rs146252570       rs147938390       rs148090394       rs150167387      
rs181768575       rs182671670       rs183682646       rs183758751       rs184182116       rs184623202       rs185198379       rs185880642       rs186636683       rs187426670       rs187635553       rs188123140       rs188764143       rs189733832       rs189812544       rs191441879       rs191753951       rs192853995       rs193166514       rs199583378       rs199818868       rs199966346       rs199980248       rs200171315       rs200217515       rs200369653       rs200466806       rs200476620       rs200673213       rs200764121       rs200766576       rs200791090       rs200869088       rs201169687       rs201182672       rs201378490       rs201488566       rs201520879       rs201772061       rs202187341       rs368678471       rs369502558       rs369524988       rs370298356       rs371373393       rs372616172       rs372645510       rs373916919       rs375546636       rs527369296       rs529480727       rs529648003       rs531826504       rs532285361       rs533668005       rs533734545       rs534210497       rs534248673       rs539031023       rs539426254       rs539650588       rs539991276       rs540235633       rs541007915       rs541167587       rs541647459       rs541957598       rs543820843       rs544751281       rs545823073       rs546797008       rs547135238       rs547363271       rs547405755       rs548154578       rs548305187       rs549576411       rs549613358       rs550167827       rs550347304       rs553837923       rs553941150       rs554657774       rs555173717       rs556158123       rs558596330       rs560032523       rs560467714       rs560895687       rs561852058       rs563794235       rs564615562       rs564840191       rs568161009       rs568395675       rs569274028       rs570195869       rs570527562       rs571869213       rs572205778       rs572578604       rs574782555       rs575132714       rs576114115       rs576986219       rs577043125       rs577913299       rs745727264       rs746978486       rs747077908       rs747543266       rs748302927       rs748344681       rs751348775       rs752121167       rs752708026       rs753254418       rs753958480       rs754013831       rs754073679       rs755108504       rs755232811       rs755513849       rs756285776       rs757448593       rs758148376       rs758807238       rs758896879       rs759782142       rs762729347       rs762738609       rs763732184       rs764790380       rs766875821       rs767486127       rs767907270       rs768121610       rs768983222       rs769150176       rs769355986       rs770751525       rs772687363       rs772918248       rs773989035       rs774836980       rs775473710       rs776306176       rs777056803       rs777791657       rs779174928       rs779793633       rs780761507       rs780929660       rs107251       rs350843       rs350844       rs350845       rs350846       rs350847       rs352491       rs352492       rs3736412       rs7246235       rs8104543       rs8110667       rs11554579       rs11666448       rs11878868       rs11880257       rs71166971       rs72979002       rs73540075       rs73918057       rs73918058       rs74172625       rs74317014       rs75244031       rs76366923       rs77353492       rs77695127       rs77743678       rs77843825       rs77899921       rs79149760       rs111252985       rs111261277       rs112118088       rs112970274       rs113342426       rs113358042       rs113411218       rs113645577       rs113715983       rs113855082       rs114189165       rs115126013       rs115180186       rs115462607       rs115900651       rs116023204       rs116239335       rs116447717       rs117385980       rs117541451       rs117833511       rs117914225       rs138281833       rs139093755       rs139094883       rs139762437       rs139818733       rs141026131       rs141646227       rs141863180       rs142857915       rs142957077       rs144013468       rs144033765       rs144184492       rs144873924       rs144977739       rs144978048       rs145386338       rs146241882       rs146420357       rs146571039       rs147362434       rs147928116       rs149015626       rs149090533       rs149192716       rs149544494       rs149696389       rs149957544       rs150065876       rs181273149       rs182118630       rs183112195       rs183226343       rs183444295       rs183525012       rs184274745       rs184573943       rs186349020       rs186575318       rs186738436       rs187941361       rs188323789       rs189021294       rs189399064       rs190501670       rs190950280       rs191157113       rs191223489       rs191314480       rs191880897       rs192450312       rs192608167       rs192661013       rs199502976       rs199567849       rs199582071       rs199584212       rs199587590       rs199592512       rs199665857       rs199809408       rs199811897       rs199849196       rs199883801       rs199934255       rs199941968       rs199958279       rs199973152       rs200117989       rs200127705       rs200174862       rs200211734       rs200218478       rs200226767       rs200236361       rs200241103       rs200245532       rs200304488       rs200364417       rs200388805       rs200395703       rs200464456       rs200478062       rs200486957       rs200522550       rs200563428       rs200625473       rs200705670       rs200742459       rs200807982       rs200813796       rs200821986       rs200860440       rs200911982       rs200930964       rs201006797       rs201007105       rs201065738       rs201136536       rs201141490       rs201177813       rs201247938       rs201293003       rs201305687       rs201408116       rs201429340       rs201448273       rs201456715       rs201461205       rs201495361       rs201527794       rs201529031       rs201553552       rs201561008       rs201585716       rs201695126       rs201722014       rs201728264       rs201733077       rs201745114       rs201757661       rs201767497       rs201770097       rs201781679       rs201845999       rs201849512       rs201974715       rs201988556       rs201995761       rs202071035       rs202077007       rs202115273       rs202169874       rs202184421       rs367819583       rs367975041       rs368033347       rs368321168       rs368376386       rs369106939       rs370210332       rs370554827       rs370737205       rs370966753       rs371866213       rs372220162       rs372423166       rs372989272       rs373335637       rs373649888       rs374156705       rs374283020       rs374642820       rs374822319       rs374941369       rs375232383       rs375854534       rs376058770       rs376138981       rs376519871       rs377050381       rs377462603       rs377542545       rs528030138       rs528648223       rs528781391       rs528808236       rs529019752       rs529373530       rs529594069       rs529607148       rs529651640       rs530393637       rs530866450       rs530963194       rs531239199       rs531707984       rs532463386       rs533039338       rs533109643       rs533266356       rs533860814       rs533901549       rs534593980       rs534630004       rs535080107       rs535134686       rs535380914       rs536019967       rs536462302       rs536619682       rs536793076       rs537805799       rs539000875       rs539119103       rs539407716       rs539521113       rs540125038       rs540200476       rs540235991       rs540429435       rs540432962       rs540831949       rs540970217       rs541013493       rs541807534       rs542969254       rs543784542       rs544659994       rs544936262       rs545394300       rs545425165       rs545815061       rs546164059       rs547405691       rs548084127       rs548702325       rs548839219       rs549451119       rs549531934       rs550552186       rs550563777       rs550982167       rs551185562       rs551219908       rs552023443       rs552134015       rs552384669       rs552403443       rs553160743       rs553458934       rs553799133       rs553860468       rs553927876       rs554000331       rs554603448       rs554642968       rs554855361       rs555196364       rs555698490       rs556124249       rs556336592       rs556375783       rs557131740       rs557597881       rs558945354       rs558959324       rs558969933       rs558994048       rs559026768       rs559531525       rs559817229       rs560056941       rs560357288       rs560458620       rs560713596       rs561394908       rs561558315       rs561764704       rs563203656       rs563413898       rs563432345       rs563498188       rs563689842       rs564214965       rs564250405       rs564526564       rs565318227       rs565384426       rs565530379       rs565567227       rs566699678       rs567405349       rs567842442       rs568486965       rs569060270       rs569333713       rs569396600       rs569593300       rs570256990       rs570295396       rs570959556       rs571169753       rs571415499       rs571698915       rs571869492       rs571983537       rs572031267       rs572295708       rs573908378       rs574033109       rs574072557       rs575910418       rs576003936       rs576277215       rs576530847       rs576952680       rs577060398       rs577187183       rs577538476       rs745356492       rs745411420       rs745815651       rs746066259       rs746092089       rs746384283       rs746507552       rs747556551       rs747712761       rs747816216       rs747846515       rs747928110       rs748020555       rs748109141       rs748222773       rs748273844       rs748511925       rs748564965       rs748943204       rs749014942       rs749208802       rs749259836       rs749484456       rs749485870       rs749695672       rs749819498       rs750267441       rs750344205       rs750346270       rs750451647       rs750787024       rs751009016       rs751163206       rs752076200       rs752226231       rs752417768       rs752642593       rs752814397       rs753029336       rs753077829       rs753324786       rs753645297       rs753676644       rs753850563       rs754189977       rs754321559       rs754376352       rs754633613       rs754722112       rs754970003       rs755449427       rs755635363       rs755757451       rs755843151       rs756097367       rs756159114       rs756423888       rs756872715       rs757131430       rs757185877       rs757305022       rs757425866       rs758377188       rs758402464       rs758533288       rs758591397       rs759282741       rs759529208       rs759660510       rs759832356       rs760425867       rs760718513       rs761006976       rs761055781       rs761159173       rs761580497       rs762151682       rs762417490       rs762517863       rs762549312       rs762568958       rs762774348       rs763073895       rs763344763       rs763468816       rs763607170       rs764059173       rs764265339       rs764401419       rs764504676       rs765325811       rs765650936       rs765776154       rs765817627       rs766273970       rs766417688       rs766580534       rs767346029       rs767475082       rs767671795       rs768131221       rs768175217       rs768445646       rs768864337       rs769236924       rs769311045       rs769700055       rs770000036       rs770115938       rs770152982       rs770203107       rs770477166       rs770742390       rs770879070       rs771404158       rs771661245       rs771714154       rs771837053       rs771850644       rs772005596       rs772254664       rs772524213       rs772876164       rs773255675       rs773361709       rs773595770       rs773648872       rs773764365       rs774118613       rs774160500       rs774393151       rs775116695       rs775280145       rs775804471       rs775965735       rs776444774       rs776496519       rs776940176       rs777026518       rs777062958       rs777448112       rs777449841       rs777453613       rs777983101       rs778143852       rs778587368       rs778792743       rs779042928       rs779282502       rs779346799       rs779418000       rs779516683       rs779743057       rs780192842       rs780247842       rs780307430       rs780645725       rs780761986       rs780834210       rs781000182       rs781775932      

基因表达

基因表达

SIRT6基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GTTCGACACCACCTTTGAG
59
GACGTACTGCGTCTTACAC
58
GTGTAAGACGCAGTACGTC
58
GAAGCTGAGGAGAGTCCTC
59
GTGTAAGACGCAGTACGTC
58
CTAGGATGGTGTCCCTCAG
59
GTGTAAGACGCAGTACGTC
58
GAAGCTGAGGAGAGTCCTC
59
AGTGTAAGACGCAGTACGT
59
GAAGCTGAGGAGAGTCCTC
59
TCGACACCACCTTTGAGAG
59
GACGTACTGCGTCTTACAC
58
CGACTTCAGGGACAAACTG
59
CTAGGATGGTGTCCCTCAG
59
GGATGTCGGTGAATTACGC
59
ACACCACACTGGAAGACTG
60
GACTTCAGGGACAAACTGG
58
CTAGGATGGTGTCCCTCAG
59
GTTCGACACCACCTTTGAG
59
GACGTACTGCGTCTTACAC
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

SIRT6基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

SIRT6基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0070403
M0QXA0(UniProtKB)
IEA
GO:0070403
M0QZ09(UniProtKB)
IEA
GO:0070403
M0R1F6(UniProtKB)
IEA
GO:0070403
M0R1N9(UniProtKB)
IEA
GO:0003247
Q8N6T7(UniProtKB)
IEA
GO:0003682
Q8N6T7(UniProtKB)
IEA
GO:0003714
Q8N6T7(UniProtKB)
IEA
GO:0003950
Q8N6T7(UniProtKB)
TAS
GO:0003956
Q8N6T7(UniProtKB)
ISS
GO:0005515
Q8N6T7(UniProtKB)
IPI
GO:0005515
Q8N6T7(UniProtKB)
IPI
GO:0005515
Q8N6T7(UniProtKB)
IPI
GO:0005634
Q8N6T7(UniProtKB)
ISS
GO:0005654
Q8N6T7(UniProtKB)
IDA
GO:0005654
Q8N6T7(UniProtKB)
TAS
GO:0005724
Q8N6T7(UniProtKB)
IDA
GO:0005737
Q8N6T7(UniProtKB)
IEA
GO:0006284
Q8N6T7(UniProtKB)
IEA
GO:0006471
Q8N6T7(UniProtKB)
ISS
GO:0006471
Q8N6T7(UniProtKB)
TAS
GO:0008270
Q8N6T7(UniProtKB)
ISS
GO:0008285
Q8N6T7(UniProtKB)
IEA
GO:0010569
Q8N6T7(UniProtKB)
IDA
GO:0017136
Q8N6T7(UniProtKB)
ISS
GO:0031648
Q8N6T7(UniProtKB)
IEA
GO:0031667
Q8N6T7(UniProtKB)
IEA
GO:0034979
Q8N6T7(UniProtKB)
TAS
GO:0042593
Q8N6T7(UniProtKB)
IEA
GO:0045820
Q8N6T7(UniProtKB)
IEA
GO:0045892
Q8N6T7(UniProtKB)
IEA
GO:0046325
Q8N6T7(UniProtKB)
IEA
GO:0046969
Q8N6T7(UniProtKB)
IDA
GO:0048146
Q8N6T7(UniProtKB)
IEA
GO:0061647
Q8N6T7(UniProtKB)
IEA
GO:0070403
Q8N6T7(UniProtKB)
ISS
GO:1990619
Q8N6T7(UniProtKB)
IEA
GO:2000648
Q8N6T7(UniProtKB)
IEA
GO:0005730
Q8N6T7(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控SIRT6基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Cardiomegaly 0.2 1 0 CTD_human_RGD
Non-alcoholic Fatty Liver Disease 0.080271442 2 0 BeFree_RGD
Transient Ischemic Attack 0.08 1 0 RGD
Obesity 0.08 1 0 RGD
Malignant neoplasm of breast 0.001085767 4 0 BeFree
Breast Carcinoma 0.001085767 4 0 BeFree
Liver carcinoma 0.001085767 4 0 BeFree
Rheumatoid Arthritis 0.000542884 2 0 BeFree
Malignant tumor of colon 0.000542884 2 0 BeFree
Non-Small Cell Lung Carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of lung 0.000542884 2 0 BeFree
Carcinogenesis 0.000542884 2 0 BeFree
Carcinoma of lung 0.000542884 2 0 BeFree
Arthritis 0.000271442 1 0 BeFree
Malignant neoplasm of urinary bladder 0.000271442 1 0 BeFree
Malignant neoplasm of endometrium 0.000271442 1 0 BeFree
Malignant neoplasm of skin 0.000271442 1 0 BeFree
Carcinoma, Transitional Cell 0.000271442 1 0 BeFree
Diabetic Retinopathy 0.000271442 1 0 BeFree
Fatty Liver 0.000271442 1 0 BeFree
Liver neoplasms 0.000271442 1 0 BeFree
Chronic Obstructive Airway Disease 0.000271442 1 0 BeFree
Lymphopenia 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Septicemia 0.000271442 1 0 BeFree
Werner Syndrome 0.000271442 1 0 BeFree
Premature aging syndrome 0.000271442 1 0 BeFree
bone destruction 0.000271442 1 0 BeFree
Sepsis 0.000271442 1 0 BeFree
Chronic liver disease 0.000271442 1 0 BeFree
Malignant neoplasm of liver 0.000271442 1 0 BeFree
Endometrial Carcinoma 0.000271442 1 0 BeFree
Squamous cell carcinoma of skin 0.000271442 1 0 BeFree
Colon Carcinoma 0.000271442 1 0 BeFree
Carcinoma of bladder 0.000271442 1 0 BeFree
Arthritis, Collagen-Induced 0.000271442 1 0 BeFree
Malignant neoplasm of ovary 0.000271442 1 0 BeFree
Squamous cell carcinoma of the head and neck 0.000271442 1 0 BeFree
Hepatocarcinogenesis 0.000271442 1 0 BeFree
Uterine Corpus Cancer 0.000271442 1 0 BeFree
Urothelial Carcinoma 0.000271442 1 0 BeFree

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