UCP1(uncoupling protein 1 (mitochondrial, proton carrier))

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

4q28-q31
基因染色体位置图

基因简述

基因简述

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  线粒体解偶联蛋白（UCP）是家庭线粒体阴离子载体蛋白（MACP）的成员。从ATP合成与作为热量耗散能量解偶联蛋白分离氧化磷酸化，也被称为线粒体质子泄漏。解偶联蛋白促进阴离子从内转移至线粒体外膜以及从外质子的返回转移到线粒体内膜。它们还降低在哺乳动物细胞中的线粒体膜电位。组织特异性发生了不同解偶联蛋白及解偶联蛋白转移H + / OH-如何不知道确切的方法。解偶联蛋白含有MACPs的三个同源蛋白结构域。该基因只在褐色脂肪组织中，一个专门的组织，其功能以产生热量表示。 [由RefSeq的，2008年7月提供]

OMIM数据库中对UCP1基因的介绍     Wikipedia数据库中对UCP1基因的介绍

基因序列

基因序列

UCP1基因的碱基序列：[NCBI]

基因突变

基因突变

UCP1基因的碱基突变：           显示全部snp
rs726989       rs1430583       rs1494808       rs1800660       rs1800661       rs2043123       rs2043124       rs2071415       rs2071416       rs2270565       rs3138733       rs3749539       rs3811787       rs3811788       rs3811789       rs3811790       rs3811791       rs3841112       rs5862487       rs6536991       rs6818140       rs6822807       rs7688743       rs7699236       rs10011540       rs11932232       rs12502572       rs13128910       rs17848355       rs17848358       rs35243591       rs36202338       rs36207118       rs36207119       rs36207120       rs36207121       rs36207122      
rs36207404       rs36207408       rs36207410       rs36207412       rs45489596       rs45539933       rs56220366       rs58739151       rs59647915       rs61450409       rs61702179       rs72943535       rs72943536       rs73856656       rs74932109       rs76031700       rs76122323       rs78055957       rs78165822       rs78724285       rs78827819       rs79001246       rs79246635       rs79610439       rs79873626       rs111460010       rs111594809       rs111849076       rs111860724       rs112019388       rs112140607       rs113620668       rs113745782       rs113783518       rs113864289       rs114470895       rs114928132       rs115099464       rs117858590       rs117949489       rs138241273       rs138611550       rs138638256       rs139398662       rs139894150       rs139917267       rs140138182       rs140778238       rs140779087       rs140830198       rs141199693       rs141520915       rs141539068       rs141663630       rs142052143       rs142145526       rs142354839       rs142396002       rs142885075       rs143645398       rs144172393       rs144354281       rs144659598       rs145372470       rs145573095       rs145918476       rs146094549       rs146114327       rs146961396       rs147250793       rs147603400       rs147701972       rs147762422       rs147778681       rs148598275       rs148892327       rs149333659       rs149419054       rs149841085       rs150067245       rs150152405       rs150658745       rs150886806       rs180868482       rs181061571       rs181932965       rs182838068       rs182883393       rs183105785       rs183997397       rs184059241       rs184542519       rs184911762       rs185601174       rs185726694       rs185921413       rs186462040       rs186534214       rs187220083       rs187612055       rs188223067       rs188940594       rs188981515       rs189312305       rs190126099       rs190380413       rs190636854       rs191838863       rs192098465       rs192333501       rs192528115       rs192632180       rs199702820       rs199920125       rs200045723       rs200354766       rs200389729       rs200660278       rs200693427       rs200874530       rs201249845       rs201346519       rs201461481       rs201558037       rs201959264       rs201976256       rs202197292       rs202215906       rs367909350       rs368167108       rs368381285       rs369633902       rs370861057       rs371007342       rs371409039       rs372198396       rs372420985       rs372451180       rs372660791       rs372704070       rs372736155       rs372823869       rs373376128       rs373376893       rs374031496       rs374147979       rs374265325       rs374310489       rs374430087       rs375432020       rs375694859       rs376000044       rs376167170       rs376457797       rs377019499       rs377122251       rs377137285       rs377616609       rs527512114       rs527960564       rs528137782       rs528178499       rs528186894       rs528929543       rs529781757       rs529933317       rs530434699       rs530503560       rs530774350       rs530936498       rs531672425       rs532257668       rs532592629       rs532718970       rs532734814       rs532909748       rs533967364       rs534102407       rs535359138       rs535826223       rs535964691       rs536021363       rs536022160       rs536085043       rs536598972       rs537599685       rs537687137       rs537726509       rs537928607       rs538120229       rs538165026       rs538257429       rs538367456       rs538400756       rs538406188       rs538491644       rs538981371       rs538988347       rs539493010       rs539685692       rs539766026       rs539961851       rs540230710       rs541682474       rs542254778       rs542879643       rs543320296       rs543753428       rs543991038       rs544058696       rs544110432       rs544313847       rs544349406       rs544637184       rs545998612       rs546015639       rs546609310       rs547179592       rs547473087       rs547884746       rs548075978       rs548271310       rs548319096       rs548974062       rs549266071       rs549281392       rs549543974       rs549546829       rs549634714       rs549815493       rs550015648       rs550307428       rs550345422       rs550542331       rs550579088       rs550995710       rs551356095       rs551633105       rs551799490       rs552271035       rs553415650       rs553417300       rs553454250       rs554334922       rs555213120       rs555285040       rs555457768       rs555800104       rs555803195       rs555884969       rs556153775       rs556306518       rs556504882       rs557718796       rs557878166       rs558049733       rs558086468       rs558574177       rs559176907       rs559250260       rs559544407       rs559714676       rs559928395       rs559962748       rs560294200       rs560451539       rs561268010       rs561382338       rs561587316       rs562168510       rs562363220       rs562565974       rs563362938       rs563588752       rs564161905       rs564208960       rs564876296       rs565467296       rs565496720       rs565553947       rs566134493       rs566209912       rs566741523       rs566764769       rs567451868       rs567550714       rs567687146       rs567743945       rs568352524       rs568656079       rs568769182       rs568784043       rs569203186       rs569650793       rs570514022       rs570726617       rs571035466       rs571666957       rs571684831       rs571767343       rs571804645       rs572906198       rs573033816       rs573045664       rs573078239       rs574561663       rs575055039       rs575093372       rs575639599       rs575998718       rs577219346       rs577307619       rs577481037       rs577520173       rs577642090       rs577971821       rs745523548       rs745628003       rs745773879       rs746477797       rs746861912       rs746909792       rs746953891       rs746972878       rs747183810       rs747261064       rs747339615       rs747529959       rs748090664       rs748125960       rs748392042       rs748606428       rs748672923       rs748866761       rs748876349       rs749050572       rs749324285       rs750195616       rs750415500       rs750591279       rs750633096       rs750811721       rs751020946       rs751162311       rs751487709       rs751699256       rs751832729       rs751943456       rs752027726       rs752414301       rs752535197       rs752625172       rs752643780       rs752671873       rs752870968       rs753041529       rs753327254       rs753712691       rs753737831       rs753813576       rs753829911       rs753939837       rs754021862       rs754111665       rs754245330       rs754333261       rs754743844       rs754761163       rs755139143       rs755390699       rs755573775       rs755584104       rs756012577       rs756098816       rs756207662       rs756369139       rs756371993       rs756459048       rs756530707       rs756723059       rs756816288       rs757041567       rs757220467       rs757559179       rs757653639       rs758015716       rs758065449       rs758145835       rs758155164       rs758177151       rs758206160       rs758833108       rs759194010       rs759825652       rs759901775       rs759933931       rs759976240       rs760215900       rs760410315       rs760753546       rs760871313       rs760957984       rs761243709       rs761334073       rs761343874       rs761433849       rs761468229       rs762107744       rs763050237       rs763137834       rs763328630       rs763335484       rs763504112       rs763701059       rs763804606       rs764044342       rs764276708       rs764423219       rs764912156       rs765046420       rs765244655       rs765401579       rs765590124       rs765672077       rs765974159       rs766175220       rs766345719       rs766625774       rs766646535       rs766778249       rs766868218       rs767034123       rs767392161       rs767705485       rs767954923       rs768048578       rs768151045       rs768769266       rs768884861       rs769084769       rs769165070       rs769209414       rs769226530       rs769316561       rs769473091       rs769525538       rs769644397       rs769912939       rs770251704       rs770376298       rs770663075       rs770868218       rs770997395       rs771475967       rs771542760       rs771837296       rs771967103       rs772089782       rs772226264       rs772563166       rs772581688       rs772583342       rs772769015       rs772882747       rs773354785       rs773444446       rs773533346       rs773673102       rs774495998       rs774544396       rs774583885       rs774928918       rs775039211       rs775118020       rs776076414       rs776088994       rs776166009       rs776265056       rs776290488       rs776624659       rs776908044       rs777035861       rs777139082       rs777211488       rs777239924       rs777643765       rs777680167       rs777925871       rs778088952       rs778096334       rs778111188       rs778654135       rs778813994       rs778831738       rs778934896       rs779693026       rs779968532       rs780247695       rs780437371       rs780622741       rs780740608       rs781476339       rs781492756       rs781515584       rs781596160      

基因表达

基因表达

UCP1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GCAGGGAAAGAAACAGCAC
60
GCCCAATGAATACTGCCAC
59
AGGGAAAGAAACAGCACCT
59
TGCCCAATGAATACTGCCA
60
CAGGGAAAGAAACAGCACC
59
GCCCAATGAATACTGCCAC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

UCP1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

UCP1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003735
P25874(UniProtKB)
IBA
GO:0005739
P25874(UniProtKB)
IDA
GO:0005743
P25874(UniProtKB)
TAS
GO:0005743
P25874(UniProtKB)
TAS
GO:0005743
P25874(UniProtKB)
TAS
GO:0005743
P25874(UniProtKB)
TAS
GO:0006357
P25874(UniProtKB)
IEA
GO:0006412
P25874(UniProtKB)
IBA
GO:0006839
P25874(UniProtKB)
IEA
GO:0015992
P25874(UniProtKB)
TAS
GO:0015992
P25874(UniProtKB)
TAS
GO:0016021
P25874(UniProtKB)
IEA
GO:0017077
P25874(UniProtKB)
IEA
GO:0050873
P25874(UniProtKB)
ISS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控UCP1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Obesity 0.164419454 67 1 BeFree_CTD_human_GAD
Peripheral Neuropathy 0.12 1 0 CTD_human
Prediabetes syndrome 0.08 1 0 RGD
Diabetes Mellitus, Non-Insulin-Dependent 0.020183845 16 5 BeFree_GAD_LHGDN
body mass 0.01183516 5 0 GAD
Hypertensive disease 0.005634266 2 0 BeFree_GAD_LHGDN
Atherosclerosis 0.005276948 4 0 BeFree_GAD
Metabolic Syndrome X 0.003995683 7 6 BeFree_GAD
Diabetic Nephropathy 0.002995792 1 0 BeFree_LHGDN
Kidney Failure, Chronic 0.002638474 2 3 BeFree_GAD
Obesity, Morbid 0.002638474 2 0 BeFree_GAD
Diabetic Neuropathies 0.002367032 1 0 GAD
Hearing Loss, Partial 0.002367032 1 0 GAD
Hypercholesterolemia 0.002367032 1 0 GAD
Liver diseases 0.002367032 1 0 GAD
Oxidative Stress 0.002367032 1 0 GAD
Blood pressure finding 0.002367032 1 0 GAD
Systemic arterial pressure 0.002367032 1 0 GAD
hearing impairment 0.002367032 1 0 GAD
Weight Loss Adverse Event 0.002367032 1 0 GAD
Diabetes Mellitus 0.002171535 8 6 BeFree
Diabetes 0.001900093 7 5 BeFree
Metabolic Diseases 0.001900093 7 0 BeFree
Overweight 0.001357209 5 1 BeFree
Arteriosclerosis 0.000814326 3 0 BeFree
Cold intolerance 0.000814326 3 0 BeFree
Burning sensation 0.000814326 3 0 BeFree
Diabetic Retinopathy 0.000542884 2 0 BeFree
Lipoma 0.000542884 2 0 BeFree
Lymphoma 0.000542884 2 0 BeFree
Malignant neoplasm of breast 0.000271442 1 0 BeFree
Cachexia 0.000271442 1 0 BeFree
Malignant tumor of colon 0.000271442 1 0 BeFree
Coronary Arteriosclerosis 0.000271442 1 0 BeFree
Diabetes Mellitus, Insulin-Dependent 0.000271442 1 0 BeFree
Heart failure 0.000271442 1 0 BeFree
Congestive heart failure 0.000271442 1 0 BeFree
Hodgkin Disease 0.000271442 1 0 BeFree
Hyperlipidemia 0.000271442 1 0 BeFree
Hyperlipidemia, Familial Combined 0.000271442 1 0 BeFree
Neoplasm Metastasis 0.000271442 1 0 BeFree
Retinal Diseases 0.000271442 1 1 BeFree
Schizophrenia 0.000271442 1 0 BeFree
T-Cell Lymphoma 0.000271442 1 0 BeFree
Secondary malignant neoplasm of bone 0.000271442 1 0 BeFree
Obesity, Abdominal 0.000271442 1 1 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
extranodal lymphoma 0.000271442 1 0 BeFree
Colon Carcinoma 0.000271442 1 0 BeFree
Dissecting aneurysm of the thoracic aorta 0.000271442 1 0 BeFree
Mammary Neoplasms 0.000271442 1 0 BeFree
Cancer Cell Growth 0.000271442 1 0 BeFree

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