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Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
[中文简述(自动翻译):]  可溶性鸟苷酸环化酶是催化GTP的3‘,5‘-环鸟苷酸和焦磷酸盐的转化的异源二聚体蛋白。由该基因编码的蛋白质是该复合物的α亚基,并将其与β亚基相互作用,以形成鸟苷酸环化酶,其通过一氧化氮激活。已发现该基因编码几个不同的亚型几个抄本变形。 [由RefSeq的,2012年1月提供]
GUCY1A3基因(以及对应的蛋白质)的细胞分布位置:
GUCY1A3基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Hypertensive disease | 0.24 | 2 | 1 | CTD_human_GWASCAT |
| MOYAMOYA DISEASE 6 WITH ACHALASIA | 0.24 | 0 | 3 | CLINVAR_ORPHANET |
| Blood pressure finding | 0.124734064 | 2 | 1 | GAD_GWASCAT |
| Systemic arterial pressure | 0.124734064 | 2 | 1 | GAD_GWASCAT |
| Colonic Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Adenoid Cystic Carcinoma | 0.12 | 1 | 0 | CTD_human |
| Salivary Gland Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Thrombosis | 0.12 | 1 | 0 | CTD_human |
| MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO, 1 (finding) | 0.12 | 0 | 1 | CLINVAR |
| Coronary Artery Disease | 0.12 | 1 | 0 | CTD_human |
| Glaucoma, Primary Open Angle | 0.08 | 0 | 0 | MGD |
| Glioma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Esophageal Achalasia | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Hypertension | 0.000271442 | 1 | 1 | BeFree |
| Moyamoya Disease | 0.000271442 | 1 | 0 | BeFree |
| Myocardial Infarction | 0.000271442 | 1 | 0 | BeFree |
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