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Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013]
[中文简述(自动翻译):]  卢GTP酶在由通过G蛋白偶联受体工作外刺激引发许多细胞过程中发挥了重要作用。由该基因编码的蛋白质可以形成以G蛋白复合物和刺激的Rho依赖性信号。编码不同同种型的多个可变剪接转录物变体已被发现,但一些变体的全长性质尚未确定。 [由RefSeq的,2013年6月提供]
ARHGEF4基因(以及对应的蛋白质)的细胞分布位置:
ARHGEF4基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
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