MYC (MYC proto-oncogene, bHLH transcription factor)

基因基本信息

基因基本信息

symbol:
MYC
locus group:
protein-coding gene
location:
8q24.21
gene_family:
Basic helix-loop-helix proteins
alias symbol:
c-Myc|bHLHe39|MYCC
alias name:
None
entrez id:
4609
ensembl gene id:
ENSG00000136997
ucsc gene id:
uc064qdk.2
refseq accession:
NM_001354870
hgnc_id:
HGNC:7553
approved reserved:
2001-06-22

基因染色体位置

基因染色体位置

8q24.21
基因染色体位置图

基因简述

基因简述

MYC基因是一种原癌基因，属于MYC基因家族，该家族还包括MYCN和MYCL等成员，它们共同的特点是编码转录因子，能够调控大量靶基因的表达，参与细胞增殖、分化、凋亡和代谢等关键生物学过程。MYC基因的表达产物c-Myc蛋白是一种核内转录因子，通过与MAX蛋白形成异源二聚体并结合到DNA的E-box序列上，激活或抑制下游靶基因的转录。c-Myc在正常细胞中调控细胞周期进程、核糖体生物合成、能量代谢和蛋白质合成等，对胚胎发育和组织稳态至关重要。然而，MYC基因的突变或异常表达会导致其功能失调，进而促进肿瘤发生。常见的MYC基因异常包括基因扩增、染色体易位（如Burkitt淋巴瘤中的t(8;14)易位）或突变，这些改变会导致c-Myc蛋白的过表达或稳定性增加，从而持续激活促增殖和抗凋亡信号通路，促进肿瘤细胞的无限增殖和恶性转化。MYC的过表达与多种癌症密切相关，如淋巴瘤、乳腺癌、肺癌和结直肠癌等。此外，MYC还通过调控microRNA和长链非编码RNA影响肿瘤微环境和免疫逃逸。如果MYC表达降低，细胞可能停滞在G1期，增殖受阻，甚至触发凋亡，因此MYC是癌症治疗的重要靶点之一。MYC基因家族成员的共性是它们都含有碱性螺旋-环-螺旋（bHLH）和亮氨酸拉链（Zip）结构域，这些结构域介导了它们与DNA或其他蛋白质的相互作用。由于MYC在肿瘤中的关键作用，针对MYC及其下游通路的小分子抑制剂或基因治疗策略正在研究中，但因其广泛的功能和复杂的调控网络，靶向MYC的治疗仍面临挑战。

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

由该基因编码的蛋白质是一种多功能的，核磷蛋白即在细胞周期进程，细胞凋亡和细胞转化的作用。它起到一种调节的特定靶基因转录的转录因子。突变，过度表达，重排和该基因的易位已与多种造血肿瘤，白血病和淋巴瘤，包括伯基特淋巴瘤有关。有证据表明，来自上游，在帧非-AUG（CUG）和下游AUG起始位点的结果在生产两种异构体具有不同的N-末端的替代翻译灌顶。非AUG启动蛋白的合成被抑制在伯基特淋巴瘤，表明该基因的正常功能的重要性。 [由RefSeq的，2008年7月提供]

OMIM数据库中对MYC基因的介绍     Wikipedia数据库中对MYC基因的介绍

基因序列

基因序列

MYC基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

MYC基因的碱基突变：           仅显示部分snp
rs3808379       rs3824120       rs4645939       rs4645940       rs4645941       rs4645942       rs4645943       rs4645944       rs4645945       rs17187428       rs28461617       rs35532759       rs71300261       rs117134852       rs117576103       rs117748025       rs141631033      

基因表达

基因表达

MYC基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GGATTCTCTGCTCTCCTCG
59
TTGTTCCTCCTCAGAGTCG
59
GGATTCTCTGCTCTCCTCG
59
TTGTTCCTCCTCAGAGTCG
59
TCTGAAAGGCTCTCCTTGC
60
TGGTGAAGCTAACGTTGAG
58
GGATTCTCTGCTCTCCTCG
59
TTGTTCCTCCTCAGAGTCG
59
GGATTCTCTGCTCTCCTCG
59
TTGTTCCTCCTCAGAGTCG
59
CTTCTCTGAAAGGCTCTCCT
59
TCGAGGTCATAGTTCCTGG
58
ATTCTCTGCTCTCCTCGAC
59
TTCTTGTTCCTCCAGAGTCG
60
GATTCTCTGCTCTCCTCGA
58
TTGTTCCTCCTCAGAGTCG
59
GATTCTCTGCTCTCCTCGA
58
TTGTTCCTCCTCAGAGTCG
59
CTTCTCTGAAAGGCTCTCC
57
TCGAGGTCATAGTTCCTGG
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
AATF
MYC
Activation
20549547
AHR
MYC
Unknown
11114727; 16091746
APC
MYC
Repression
16510874
AR
MYC
Unknown
24512546
BCL6
MYC
Activation
21394099
BDP1
MYC
Unknown
12734418
BIN1
MYC
Unknown
9797456
BRCA1
MYC
Unknown
12032322; 12646176
CEBPA
MYC
Repression
12032779
CEBPE
MYC
Repression
12947005

基因本体信息

MYC基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

MYC基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003700
A0A087WUS5 (UniProtKB)
IEA
GO:0005634
A0A087WUS5 (UniProtKB)
IEA
GO:0005819
A0A087WUS5 (UniProtKB)
IEA
GO:0006355
A0A087WUS5 (UniProtKB)
IEA
GO:0046983
A0A087WUS5 (UniProtKB)
IEA
GO:0003700
A0A0B4J1R1 (UniProtKB)
IEA
GO:0005634
A0A0B4J1R1 (UniProtKB)
IEA
GO:0006355
A0A0B4J1R1 (UniProtKB)
IEA
GO:0003700
H0YBG3 (UniProtKB)
IEA
GO:0005634
H0YBG3 (UniProtKB)
IEA
GO:0006355
H0YBG3 (UniProtKB)
IEA
GO:0003700
H0YBT0 (UniProtKB)
IEA
GO:0005654
H0YBT0 (UniProtKB)
IDA
GO:0006355
H0YBT0 (UniProtKB)
IEA
GO:0046983
H0YBT0 (UniProtKB)
IEA
GO:0000122
P01106 (UniProtKB)
IDA
GO:0000165
P01106 (UniProtKB)
IMP
GO:0000978
P01106 (UniProtKB)
IDA
GO:0001077
P01106 (UniProtKB)
IDA
GO:0001658
P01106 (UniProtKB)
ISS
GO:0002053
P01106 (UniProtKB)
ISS
GO:0003677
P01106 (UniProtKB)
ISS
GO:0003677
P01106 (UniProtKB)
TAS
GO:0003700
P01106 (UniProtKB)
IDA
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005515
P01106 (UniProtKB)
IPI
GO:0005634
P01106 (UniProtKB)
IDA
GO:0005634
P01106 (UniProtKB)
IDA
GO:0005634
P01106 (UniProtKB)
IDA
GO:0005654
P01106 (UniProtKB)
IDA
GO:0005654
P01106 (UniProtKB)
IDA
GO:0005654
P01106 (UniProtKB)
TAS
GO:0005654
P01106 (UniProtKB)
TAS
GO:0005654
P01106 (UniProtKB)
TAS
GO:0005654
P01106 (UniProtKB)
TAS
GO:0005654
P01106 (UniProtKB)
TAS
GO:0005730
P01106 (UniProtKB)
IDA
GO:0005829
P01106 (UniProtKB)
TAS
GO:0006112
P01106 (UniProtKB)
NAS
GO:0006338
P01106 (UniProtKB)
IDA
GO:0006366
P01106 (UniProtKB)
IEA
GO:0006879
P01106 (UniProtKB)
IDA
GO:0006974
P01106 (UniProtKB)
IDA
GO:0007050
P01106 (UniProtKB)
IDA
GO:0007219
P01106 (UniProtKB)
TAS
GO:0008134
P01106 (UniProtKB)
IPI
GO:0008284
P01106 (UniProtKB)
IDA
GO:0010332
P01106 (UniProtKB)
IDA
GO:0010468
P01106 (UniProtKB)
IDA
GO:0015671
P01106 (UniProtKB)
NAS
GO:0032204
P01106 (UniProtKB)
IMP
GO:0032403
P01106 (UniProtKB)
IDA
GO:0032873
P01106 (UniProtKB)
ISS
GO:0034644
P01106 (UniProtKB)
IEP
GO:0035690
P01106 (UniProtKB)
IDA
GO:0035690
P01106 (UniProtKB)
IDA
GO:0042493
P01106 (UniProtKB)
IEP
GO:0043066
P01106 (UniProtKB)
ISS
GO:0043234
P01106 (UniProtKB)
IDA
GO:0043280
P01106 (UniProtKB)
IDA
GO:0044346
P01106 (UniProtKB)
TAS
GO:0045656
P01106 (UniProtKB)
IMP
GO:0045893
P01106 (UniProtKB)
IDA
GO:0045893
P01106 (UniProtKB)
IDA
GO:0045893
P01106 (UniProtKB)
IDA
GO:0045944
P01106 (UniProtKB)
IDA
GO:0045944
P01106 (UniProtKB)
IMP
GO:0045944
P01106 (UniProtKB)
TAS
GO:0046983
P01106 (UniProtKB)
IEA
GO:0048146
P01106 (UniProtKB)
IMP
GO:0048146
P01106 (UniProtKB)
IDA
GO:0048146
P01106 (UniProtKB)
IDA
GO:0048147
P01106 (UniProtKB)
IDA
GO:0050679
P01106 (UniProtKB)
IDA
GO:0051276
P01106 (UniProtKB)
IDA
GO:0051782
P01106 (UniProtKB)
IDA
GO:0060070
P01106 (UniProtKB)
IDA
GO:0070491
P01106 (UniProtKB)
IPI
GO:0070848
P01106 (UniProtKB)
TAS
GO:0070888
P01106 (UniProtKB)
IDA
GO:0090096
P01106 (UniProtKB)
ISS
GO:1904837
P01106 (UniProtKB)
TAS
GO:2000573
P01106 (UniProtKB)
IMP
GO:2001022
P01106 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 MYC基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Burkitt Lymphoma 0.495996478 134 4 BeFree_CLINVAR_CTD_human_LHGDN_MGD_ORPHANET
Liver carcinoma 0.305750759 56 0 BeFree_CTD_human_GAD_LHGDN_MGD_RGD
Colonic Neoplasms 0.203538676 9 0 BeFree_CTD_human_LHGDN_RGD
Liver Neoplasms, Experimental 0.2 4 0 CTD_human_RGD
Medulloblastoma 0.139845051 46 0 BeFree_CTD_human_LHGDN
Neoplasm Metastasis 0.138392034 51 0 BeFree_CTD_human_GAD_LHGDN
Prostatic Neoplasms 0.137974753 13 0 BeFree_CTD_human_LHGDN
Leukemia, Myelocytic, Acute 0.13549205 38 0 BeFree_CTD_human_LHGDN
Neuroblastoma 0.129771907 37 0 BeFree_CTD_human
Liver neoplasms 0.128977445 17 0 BeFree_CTD_human_LHGDN

基因相关服务

基因相关服务

联系方式

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