FGF20 (fibroblast growth factor 20)
- symbol:
- FGF20
- locus group:
- protein-coding gene
- location:
- 8p22
- gene_family:
- alias symbol:
- None
- alias name:
- None
- entrez id:
- 26281
- ensembl gene id:
- ENSG00000078579
- ucsc gene id:
- uc003wxc.2
- refseq accession:
- NM_019851
- hgnc_id:
- HGNC:3677
- approved reserved:
- 1999-11-19
FGF20（成纤维细胞生长因子20）属于FGF基因家族，该家族包含22个成员，主要参与细胞增殖、分化、迁移和存活等生物学过程。FGF20在胚胎发育、组织修复和代谢调节中发挥重要作用，尤其在神经系统和毛囊发育中表现突出。FGF20通过激活FGFR受体（通常是FGFR1c和FGFR3c）和下游MAPK、PI3K/AKT等信号通路发挥作用，主要表达于大脑（如黑质和纹状体）、肾脏和皮肤等组织。FGF20的突变可能导致功能丧失，与帕金森病风险增加相关（如rs1721100多态性），还可能影响毛囊发育导致脱发。该基因过表达可能促进肿瘤发生（如胶质瘤和乳腺癌），因其刺激细胞增殖和血管生成；而表达降低则可能损害神经保护功能或导致发育异常。FGF家族成员的共性是依赖肝素/硫酸乙酰肝素结合来激活受体，多数以旁分泌方式发挥作用（FGF15/19/21/23除外）。FGF20与家族成员FGF9和FGF16具有高度同源性，三者构成FGF9亚家族，均参与器官形成。研究还发现FGF20能与其他生长因子（如WNT）协同调控毛囊周期，其表达异常可能破坏这种平衡。
None
无
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GGAGAAACTTACTTCCGAATGC
60
CCGTCTTTGTTAAGTGCCAC
60
GCCTCTTCGGTATCTTGGA
59
CAAGATAGAGACCACTGTCCA
59
AGCCTCTTCGGTATCTTGG
59
AAGATAGAGACCACTGTCCAC
59
GGAGAAACTTACTTCCGAATGC
60
CCGTCTTTGTTAAGTGCCA
58
CTCTTCGGAGAAACTTACTTCC
59
ATACCAGTTCTCTTCAAACTGC
59
GTATTAGAGGTGTGGACAGTG
58
CGGAAGTAAGTTTCTCTGATCC
59
基因本体信息
FGF20基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
FGF20基因的本体（GO）信息：
GO库代码
对应的蛋白质
来源代码
GO:0005104
H0YAT9 (UniProtKB)
IEA
GO:0005576
H0YAT9 (UniProtKB)
IEA
GO:0008083
H0YAT9 (UniProtKB)
IEA
GO:0008543
H0YAT9 (UniProtKB)
IEA
GO:0000165
Q9NP95 (UniProtKB)
TAS
GO:0004713
Q9NP95 (UniProtKB)
TAS
GO:0005088
Q9NP95 (UniProtKB)
TAS
GO:0005104
Q9NP95 (UniProtKB)
IEA
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005576
Q9NP95 (UniProtKB)
TAS
GO:0005622
Q9NP95 (UniProtKB)
IEA
GO:0005622
Q9NP95 (UniProtKB)
IEA
GO:0007165
Q9NP95 (UniProtKB)
TAS
GO:0007267
Q9NP95 (UniProtKB)
TAS
GO:0008083
Q9NP95 (UniProtKB)
IEA
GO:0008284
Q9NP95 (UniProtKB)
IEA
GO:0008543
Q9NP95 (UniProtKB)
TAS
GO:0008543
Q9NP95 (UniProtKB)
TAS
GO:0008543
Q9NP95 (UniProtKB)
TAS
GO:0008543
Q9NP95 (UniProtKB)
TAS
GO:0008543
Q9NP95 (UniProtKB)
TAS
GO:0008543
Q9NP95 (UniProtKB)
TAS
GO:0008543
Q9NP95 (UniProtKB)
TAS
GO:0008543
Q9NP95 (UniProtKB)
TAS
GO:0008543
Q9NP95 (UniProtKB)
TAS
GO:0014066
Q9NP95 (UniProtKB)
TAS
GO:0016303
Q9NP95 (UniProtKB)
TAS
GO:0018108
Q9NP95 (UniProtKB)
IEA
GO:0036092
Q9NP95 (UniProtKB)
IEA
GO:0043547
Q9NP95 (UniProtKB)
IEA
GO:0046854
Q9NP95 (UniProtKB)
IEA
GO:0046934
Q9NP95 (UniProtKB)
TAS
GO:0048015
Q9NP95 (UniProtKB)
TAS
GO:0060043
Q9NP95 (UniProtKB)
IEA
GO:0060113
Q9NP95 (UniProtKB)
IEA
GO:0070374
Q9NP95 (UniProtKB)
IEA
| 名称 |
|---|
| 4014 Ras signaling pathway [PATH:hsa04014] |
| 4015 Rap1 signaling pathway [PATH:hsa04015] |
| 4010 MAPK signaling pathway [PATH:hsa04010] |
| 4151 PI3K-Akt signaling pathway [PATH:hsa04151] |
| 4810 Regulation of actin cytoskeleton [PATH:hsa04810] |
| 5200 Pathways in cancer [PATH:hsa05200] |
| 5218 Melanoma [PATH:hsa05218] |
| 名称 |
|---|
| Activated point mutants of FGFR2 |
| Adaptive Immune System |
| Constitutive Signaling by Aberrant PI3K in Cancer |
| DAP12 interactions |
| DAP12 signaling |
| Disease |
| Diseases of signal transduction |
| Downstream signal transduction |
| Downstream signaling events of B Cell Receptor (BCR) |
| Downstream signaling of activated FGFR1 |
| Downstream signaling of activated FGFR2 |
| Downstream signaling of activated FGFR3 |
| Downstream signaling of activated FGFR4 |
| Fc epsilon receptor (FCERI) signaling |
| FGFR1 ligand binding and activation |
| FGFR1 mutant receptor activation |
| FGFR1c ligand binding and activation |
| FGFR2 ligand binding and activation |
| FGFR2 mutant receptor activation |
| FGFR2c ligand binding and activation |
| FGFR3 ligand binding and activation |
| FGFR3 mutant receptor activation |
| FGFR3b ligand binding and activation |
| FGFR3c ligand binding and activation |
| FGFR4 ligand binding and activation |
| FRS-mediated FGFR1 signaling |
| FRS-mediated FGFR2 signaling |
| FRS-mediated FGFR3 signaling |
| FRS2-mediated FGFR4 signaling |
| GAB1 signalosome |
| IGF1R signaling cascade |
| Immune System |
| Innate Immune System |
| Insulin receptor signalling cascade |
| IRS-mediated signalling |
| IRS-related events |
| IRS-related events triggered by IGF1R |
| Negative regulation of FGFR1 signaling |
| Negative regulation of FGFR2 signaling |
| Negative regulation of FGFR3 signaling |
| Negative regulation of FGFR4 signaling |
| NGF signalling via TRKA from the plasma membrane |
| Phospholipase C-mediated cascade; FGFR2 |
| Phospholipase C-mediated cascade; FGFR3 |
| Phospholipase C-mediated cascade; FGFR4 |
| Phospholipase C-mediated cascade: FGFR1 |
| PI-3K cascade:FGFR1 |
| PI-3K cascade:FGFR2 |
| PI-3K cascade:FGFR3 |
| PI-3K cascade:FGFR4 |
| PI3K Cascade |
| PI3K events in ERBB2 signaling |
| PI3K events in ERBB4 signaling |
| PI3K/AKT activation |
| PI3K/AKT Signaling in Cancer |
| PIP3 activates AKT signaling |
| Role of LAT2/NTAL/LAB on calcium mobilization |
| SHC-mediated cascade:FGFR1 |
| SHC-mediated cascade:FGFR2 |
| SHC-mediated cascade:FGFR3 |
| SHC-mediated cascade:FGFR4 |
| Signal Transduction |
| Signaling by activated point mutants of FGFR1 |
| Signaling by activated point mutants of FGFR3 |
| Signaling by EGFR |
| Signaling by ERBB2 |
| Signaling by ERBB4 |
| Signaling by FGFR |
| Signaling by FGFR in disease |
| Signaling by FGFR1 |
| Signaling by FGFR1 in disease |
| Signaling by FGFR1 mutants |
| Signaling by FGFR2 |
| Signaling by FGFR2 in disease |
| Signaling by FGFR2 mutants |
| Signaling by FGFR3 |
| Signaling by FGFR3 in disease |
| Signaling by FGFR3 mutants |
| Signaling by FGFR4 |
| Signaling by FGFR4 in disease |
| Signaling by FGFR4 mutants |
| Signaling by Insulin receptor |
| Signaling by PDGF |
| Signaling by SCF-KIT |
| Signaling by the B Cell Receptor (BCR) |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| Signalling by NGF |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| RENAL HYPODYSPLASIA/APLASIA 2 | 0.12 | 0 | 1 | CLINVAR |
| Congenital absence of kidneys syndrome | 0.12 | 0 | 0 | ORPHANET |
| PARKINSON DISEASE, LATE-ONSET | 0.12 | 0 | 0 | CTD_human |
| Parkinson Disease | 0.029452594 | 10 | 1 | BeFree_GAD_LHGDN |
| Colorectal Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
| Hearing Loss, Mixed Conductive-Sensorineural | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Non-alcoholic Fatty Liver Disease | 0.000271442 | 1 | 0 | BeFree |
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