CDKN1B基因详情-基因数据库-基因云馆

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CDKN1B (cyclin dependent kinase inhibitor 1B)

symbol:: CDKN1B
locus group:: protein-coding gene
location:: 12p13.1
gene_family:
alias symbol:: KIP1|P27KIP1
alias name:: None
entrez id:: 1027
ensembl gene id:: ENSG00000111276
ucsc gene id:: uc001rat.3
refseq accession:: NM_004064
hgnc_id:: HGNC:1785
approved reserved:: 1995-09-14

12p13.1

CDKN1B基因编码的蛋白是细胞周期蛋白依赖性激酶抑制剂1B（也称为p27或Kip1），属于CIP/KIP家族（CDK抑制蛋白家族）。这个基因家族包括CDKN1A（p21）、CDKN1B（p27）和CDKN1C（p57），它们共同的特点是能够结合并抑制细胞周期蛋白依赖性激酶（CDKs），从而调控细胞周期进程，特别是在G1期到S期的过渡中起关键作用。CDKN1B的主要功能是通过抑制CDK2/cyclin E和CDK2/cyclin A复合物的活性来阻止细胞周期进程，从而控制细胞增殖。它在多种组织中广泛表达，尤其在静止或分化细胞中表达较高。CDKN1B的突变或表达异常与多种疾病相关，特别是癌症。例如，CDKN1B的功能丧失性突变或表达降低会导致细胞周期失控，促进肿瘤发生，已在乳腺癌、前列腺癌、结肠癌等多种癌症中观察到CDKN1B的表达下调或缺失。此外，CDKN1B的过表达通常与细胞周期停滞和细胞衰老相关，可能在某些情况下抑制肿瘤发展。CDKN1B的表达受多种信号通路调控，包括TGF-β、PI3K/AKT和FOXO等。AKT可通过磷酸化CDKN1B促进其降解，从而解除其对细胞周期的抑制。CDKN1B还与细胞分化、凋亡和迁移等过程有关。在免疫系统中，CDKN1B对T细胞的稳态和功能有重要影响，其缺失可能导致自身免疫性疾病。CDKN1B基因的遗传变异也与一些内分泌疾病相关，如多发性内分泌腺瘤综合征（MEN）。总的来说，CDKN1B是一个关键的细胞周期调控因子，其表达水平的异常会显著影响细胞增殖和机体稳态，与多种疾病特别是癌症的发生发展密切相关。

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

此基因编码细胞周期蛋白依赖性激酶抑制剂，这股用CDK抑制剂CDKN1A / p21的一个有限的相似性。所编码的蛋白质结合并阻止细胞周期蛋白E-CDK2或细胞周期蛋白D-CDK4复合物的活化，从而控制在G1中的细胞周期进展。该蛋白质，其通过它的CDK依赖性磷酸化并通过SCF复合物随后泛素化引发的劣化，需要用于从静止到增殖状态的细胞迁移。在这种基因突变与多发性内分泌腺瘤IV型（MEN4）相关联。 [由RefSeq的，2014年4月提供]

OMIM数据库中对CDKN1B基因的介绍 Wikipedia数据库中对CDKN1B基因的介绍

CDKN1B基因的碱基序列：[NCBI]

Loading Gene Browser...

CDKN1B基因的碱基突变：仅显示部分snp

rs7330 rs10237 rs34326 rs34327 rs34328 rs34329 rs34330 rs248743 rs1042935 rs1042937 rs2066827 rs2066828 rs2277396 rs3093728 rs3093729 rs3093730 rs3093731

CDKN1B基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

CAAAGACTGATCCGTCGGA

TAGAAGAATCGTCGGTTGCA

TGCAGAGACATGGAAGAGG

TTTGAGTAGAAGAATCCTCTAGGG

TTCTGTGGCAAGGAAACCT

GAATGTGACAGCTGGAAGG

AACCGACGATACATCACTG

TCCATTCCATGAAGTCAGC

AAAGACTGATCCGTCGGAC

GTAGAAGAATCGTCGGTTGC

CAACCGACGATACATCACTG

CATTCCATGAAGTCAGCGA

AGGAGAGGGTTAAACCACAG

GAGTAGAAGAATCTCATCTCATACG

CTGCAGAGACATGGAAGAG

TGAGTAGAAGAATCCTCTAGGG

AAGGAGAGGGTTAAACCACAG

GTAGAAGAATCTCATCTCATACGC

AACCGACGATACATCACTG

CATTCCATGAAGTCAGCGA

转录因子

影响基因

影响类型

参考文献链接（PubMed）

BRCA1

CDKN1B

Activation

18025037

BRCA1

CDKN1B

Unknown

16331276

COPS5

CDKN1B

Repression

16951171

CUX1

CDKN1B

Unknown

19332113

ESR1

CDKN1B

Repression

17681750

FHL2

CDKN1B

Activation

21377781

FOXO1

CDKN1B

Activation

21418583

HOXB7

CDKN1B

Repression

21474578

ING4

CDKN1B

Activation

20707719

ING4

CDKN1B

Unknown

18399550

CDKN1B基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

CDKN1B基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0004861

E7ES52 (UniProtKB)

IEA

GO:0005634

E7ES52 (UniProtKB)

IEA

GO:0005737

E7ES52 (UniProtKB)

IEA

GO:0007050

E7ES52 (UniProtKB)

IEA

GO:0042127

E7ES52 (UniProtKB)

IEA

GO:0071901

E7ES52 (UniProtKB)

IEA

GO:0004861

H7C2T1 (UniProtKB)

IEA

GO:0005634

H7C2T1 (UniProtKB)

IEA

GO:0005737

H7C2T1 (UniProtKB)

IEA

GO:0007050

H7C2T1 (UniProtKB)

IEA

GO:0042127

H7C2T1 (UniProtKB)

IEA

GO:0071901

H7C2T1 (UniProtKB)

IEA

GO:0000079

P46527 (UniProtKB)

TAS

GO:0000082

P46527 (UniProtKB)

IDA

GO:0000082

P46527 (UniProtKB)

TAS

GO:0001666

P46527 (UniProtKB)

IEA

GO:0004861

P46527 (UniProtKB)

TAS

GO:0004861

P46527 (UniProtKB)

TAS

GO:0005072

P46527 (UniProtKB)

TAS

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005515

P46527 (UniProtKB)

IPI

GO:0005634

P46527 (UniProtKB)

IDA

GO:0005634

P46527 (UniProtKB)

IDA

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005654

P46527 (UniProtKB)

TAS

GO:0005737

P46527 (UniProtKB)

IDA

GO:0005768

P46527 (UniProtKB)

IEA

GO:0005829

P46527 (UniProtKB)

TAS

GO:0005829

P46527 (UniProtKB)

TAS

GO:0005829

P46527 (UniProtKB)

TAS

GO:0005829

P46527 (UniProtKB)

TAS

GO:0005829

P46527 (UniProtKB)

TAS

GO:0005829

P46527 (UniProtKB)

TAS

GO:0005829

P46527 (UniProtKB)

TAS

GO:0006813

P46527 (UniProtKB)

IEA

GO:0006919

P46527 (UniProtKB)

IDA

GO:0006977

P46527 (UniProtKB)

TAS

GO:0006977

P46527 (UniProtKB)

TAS

GO:0007050

P46527 (UniProtKB)

IMP

GO:0007219

P46527 (UniProtKB)

IEA

GO:0007605

P46527 (UniProtKB)

IEA

GO:0008284

P46527 (UniProtKB)

IEA

GO:0008285

P46527 (UniProtKB)

IDA

GO:0008285

P46527 (UniProtKB)

IMP

GO:0009749

P46527 (UniProtKB)

IEA

GO:0010942

P46527 (UniProtKB)

IDA

GO:0019903

P46527 (UniProtKB)

IPI

GO:0030308

P46527 (UniProtKB)

IDA

GO:0030544

P46527 (UniProtKB)

IEA

GO:0031116

P46527 (UniProtKB)

IEA

GO:0031464

P46527 (UniProtKB)

IDA

GO:0032355

P46527 (UniProtKB)

IEA

GO:0032403

P46527 (UniProtKB)

IEA

GO:0033673

P46527 (UniProtKB)

IDA

GO:0042326

P46527 (UniProtKB)

IDA

GO:0042493

P46527 (UniProtKB)

IEA

GO:0043066

P46527 (UniProtKB)

IEA

GO:0043200

P46527 (UniProtKB)

IEA

GO:0043434

P46527 (UniProtKB)

IEA

GO:0045732

P46527 (UniProtKB)

IDA

GO:0045736

P46527 (UniProtKB)

IEA

GO:0045736

P46527 (UniProtKB)

IEA

GO:0045737

P46527 (UniProtKB)

IEA

GO:0045787

P46527 (UniProtKB)

TAS

GO:0045892

P46527 (UniProtKB)

IDA

GO:0045930

P46527 (UniProtKB)

IDA

GO:0046686

P46527 (UniProtKB)

IEA

GO:0048102

P46527 (UniProtKB)

IDA

GO:0048839

P46527 (UniProtKB)

IEA

GO:0051087

P46527 (UniProtKB)

IEA

GO:0051271

P46527 (UniProtKB)

IEA

GO:0060770

P46527 (UniProtKB)

IEA

GO:0071236

P46527 (UniProtKB)

IEA

GO:0071285

P46527 (UniProtKB)

IDA

GO:0071407

P46527 (UniProtKB)

IEA

GO:0071850

P46527 (UniProtKB)

IDA

GO:1904706

P46527 (UniProtKB)

IMP

GO:0008656

P46527 (UniProtKB)

IDA

可能调控 CDKN1B基因的相关microRNA：

hsa-mir-199a hsa-miR-221 hsa-miR-222 hsa-miR-24 hsa-miR-98 hsa-let-7a hsa-miR-106b hsa-miR-106b* hsa-miR-139-3p hsa-miR-139-5p

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4012 ErbB signaling pathway [PATH:hsa04012]
4066 HIF-1 signaling pathway [PATH:hsa04066]
4068 FoxO signaling pathway [PATH:hsa04068]
4151 PI3K-Akt signaling pathway [PATH:hsa04151]
4110 Cell cycle [PATH:hsa04110]
5200 Pathways in cancer [PATH:hsa05200]
5202 Transcriptional misregulation in cancers [PATH:hsa05202]
5206 MicroRNAs in cancer [PATH:hsa05206]
5203 Viral carcinogenesis [PATH:hsa05203]
5220 Chronic myeloid leukemia [PATH:hsa05220]
5215 Prostate cancer [PATH:hsa05215]
5222 Small cell lung cancer [PATH:hsa05222]
5162 Measles [PATH:hsa05162]
5161 Hepatitis B [PATH:hsa05161]
5169 Epstein-Barr virus infection [PATH:hsa05169]

名称
Adaptive Immune System
AKT phosphorylates targets in the cytosol
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Cellular responses to stress
Cellular Senescence
Constitutive Signaling by AKT1 E17K in Cancer
Cyclin A:Cdk2-associated events at S phase entry
Cyclin D associated events in G1
Cyclin E associated events during G1/S transition
DAP12 interactions
DAP12 signaling
Disease
Diseases of signal transduction
DNA Damage/Telomere Stress Induced Senescence
DNA Replication
Downstream signal transduction
Downstream signaling events of B Cell Receptor (BCR)
Downstream signaling of activated FGFR1
Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
Downstream signaling of activated FGFR4
Fc epsilon receptor (FCERI) signaling
G1 Phase
G1/S DNA Damage Checkpoints
G1/S Transition
GAB1 signalosome
Immune System
Innate Immune System
Mitotic G1-G1/S phases
NGF signalling via TRKA from the plasma membrane
Orc1 removal from chromatin
p53-Dependent G1 DNA Damage Response
p53-Dependent G1/S DNA damage checkpoint
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
PI3K events in ERBB2 signaling
PI3K events in ERBB4 signaling
PI3K/AKT activation
PI3K/AKT Signaling in Cancer
PIP3 activates AKT signaling
Regulation of DNA replication
Removal of licensing factors from origins
RHO GTPase Effectors
RHO GTPases activate CIT
Role of LAT2/NTAL/LAB on calcium mobilization
S Phase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
Signal Transduction
Signaling by EGFR
Signaling by ERBB2
Signaling by ERBB4
Signaling by FGFR
Signaling by FGFR1
Signaling by FGFR2
Signaling by FGFR3
Signaling by FGFR4
Signaling by PDGF
Signaling by Rho GTPases
Signaling by SCF-KIT
Signaling by the B Cell Receptor (BCR)
Signalling by NGF
Switching of origins to a post-replicative state
Synthesis of DNA

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Multiple Endocrine Neoplasia, Type IV	0.36	0	6	CLINVAR_CTD_human_ORPHANET
Neuroendocrine Tumors	0.243267234	3	3	BeFree_CLINVAR_CTD_human_LHGDN
Mammary Neoplasms	0.158955229	18	0	BeFree_CTD_human_LHGDN
Prostatic Neoplasms	0.153692094	18	0	BeFree_CTD_human_GAD_LHGDN
Liver carcinoma	0.145770622	34	0	BeFree_CTD_human_GAD_LHGDN
Multiple Endocrine Neoplasia Type 1	0.133268314	17	0	BeFree_GAD_ORPHANET
Pituitary Neoplasms	0.128620127	16	0	BeFree_CTD_human_GAD_LHGDN
Prostatic Intraepithelial Neoplasias	0.123267234	3	0	BeFree_CTD_human_LHGDN
ovarian neoplasm	0.123267234	4	0	BeFree_CTD_human_LHGDN
Lung Neoplasms	0.122995792	5	0	BeFree_CTD_human_LHGDN

联系方式

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CDKN1B (cyclin dependent kinase inhibitor 1B)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

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