PPIA(peptidylprolyl isomerase A (cyclophilin A)) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

7p13
基因染色体位置图

基因简述

基因简述

This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  该基因编码的肽基脯氨酰顺反异构酶（PPIase）家族的一个成员。 PPIases催化寡脯氨酸酰亚胺肽键顺反异构化和加速的蛋白质的折叠。所编码的蛋白质是一个环孢菌素结合蛋白和在环孢菌素A介导的免疫抑制可以发挥作用。该蛋白还可以与若干HIV蛋白，包括P55的gag，Vpr基因和衣壳蛋白相互作用，并已被证明是必要的感染性的HIV病毒体的形成。已经报道了映射到不同的染色体的多个假。 [由RefSeq的，2008年7月提供]

OMIM数据库中对PPIA基因的介绍     Wikipedia数据库中对PPIA基因的介绍

基因序列

基因序列

PPIA基因的碱基序列：[NCBI]

基因突变

基因突变

PPIA基因的碱基突变：           显示全部snp
rs6850       rs3735481       rs4720485       rs6970925       rs8177826       rs11539970       rs13221905       rs17860040       rs17860041       rs17860043       rs17860044       rs17860045       rs17860046       rs17860047       rs17860048       rs17860051       rs17860052       rs17860053       rs17860054       rs61732887       rs77433540       rs77932557       rs111547799       rs112111772       rs112230193       rs112339519       rs113563018       rs114081784       rs141337259       rs142952779       rs144989302       rs149598294       rs181551443       rs184445281       rs184721562       rs184976433       rs189764532      
rs199576292       rs200534700       rs201035574       rs367908354       rs368362572       rs368959541       rs369110807       rs369225394       rs371436086       rs371831534       rs373317060       rs373612022       rs373732482       rs375164697       rs377412687       rs377578738       rs397804203       rs528081179       rs529901060       rs530225759       rs531203871       rs531258080       rs531259252       rs531718524       rs532439647       rs532486263       rs532505886       rs532948949       rs534689521       rs534714013       rs534761929       rs535292692       rs536245139       rs536511873       rs537193644       rs538854446       rs538991010       rs541379213       rs541555586       rs541667129       rs543665952       rs545782966       rs546376341       rs547695443       rs547986837       rs548723484       rs549067605       rs549372493       rs549720671       rs549859853       rs550393180       rs551574537       rs552219683       rs552782626       rs552899383       rs553159589       rs553306509       rs554032656       rs554240994       rs554585437       rs556707041       rs558541946       rs558558765       rs558677140       rs559609252       rs559945278       rs561045791       rs561381238       rs563551365       rs563839117       rs563917157       rs564109037       rs564772931       rs565038857       rs565041608       rs565107731       rs566129007       rs566383502       rs566798845       rs568065436       rs568083507       rs570368288       rs570438650       rs570585479       rs571486040       rs572608203       rs574853561       rs575184350       rs575895000       rs575927860       rs745341775       rs747115083       rs747888881       rs750997795       rs753009869       rs753167280       rs753532129       rs753858720       rs754339936       rs754543292       rs754628954       rs755877415       rs755967080       rs756501298       rs758467485       rs759106028       rs759713152       rs762270449       rs763033584       rs767206678       rs769045177       rs769818376       rs772150396       rs773289798       rs775674262       rs776617362       rs776812451       rs777466554       rs777499763       rs777755416       rs778274599       rs778939899       rs779471856       rs781027290       rs4205       rs6904       rs14869       rs725645       rs2331170       rs4724325       rs6463247       rs6956212       rs7784201       rs8177827       rs8177828       rs8177829       rs8177830       rs9638978       rs10249442       rs10256842       rs10627827       rs10951772       rs11547706       rs11984372       rs12702088       rs17860038       rs17860057       rs17860059       rs17860062       rs17860064       rs17860067       rs17860068       rs17860069       rs17860070       rs17860072       rs17860074       rs17860077       rs17860078       rs17860079       rs17860080       rs17860081       rs17860082       rs17860084       rs17860085       rs17860086       rs17860087       rs17860088       rs17860089       rs17860090       rs17860093       rs17860094       rs17860095       rs17860098       rs17860099       rs17860100       rs17860101       rs17860103       rs28403980       rs36119683       rs55749141       rs57534886       rs60471039       rs61729600       rs61747110       rs61747111       rs61747112       rs71011986       rs71565917       rs75289788       rs75524633       rs76326832       rs77180519       rs77559738       rs78710940       rs79682839       rs111573845       rs111718472       rs111735829       rs111764561       rs112278761       rs112546912       rs112944308       rs113342552       rs113453780       rs113555362       rs116379958       rs116695343       rs118096718       rs138811894       rs139105425       rs139412776       rs139506964       rs140505462       rs140986835       rs141838679       rs142406481       rs142697350       rs143238351       rs143350466       rs144790995       rs145435158       rs145932868       rs147032878       rs148317436       rs149127139       rs149284746       rs149705415       rs180875884       rs180885455       rs181164108       rs182956448       rs183605487       rs184545266       rs186066318       rs186484171       rs187294715       rs187381845       rs188184007       rs190180753       rs190483895       rs190544520       rs190724157       rs190840867       rs191837591       rs192603333       rs199872473       rs368989197       rs369186134       rs369986305       rs370575580       rs371860718       rs374776200       rs375203095       rs376736686       rs377012980       rs377187414       rs386544857       rs397704534       rs527679277       rs528218697       rs528873600       rs530445666       rs531601611       rs531664423       rs531716578       rs532605623       rs532899916       rs533375328       rs534061816       rs534697821       rs534741910       rs535399349       rs535850928       rs535919309       rs536202987       rs536386438       rs538049924       rs538196027       rs539259201       rs539620108       rs539704376       rs539726282       rs540303714       rs541219840       rs541282758       rs541358110       rs541494784       rs542396602       rs542405275       rs542517958       rs542563630       rs543664080       rs543830062       rs544490072       rs545068176       rs545279607       rs546503585       rs547761897       rs547925179       rs548241826       rs548855403       rs548898832       rs549931742       rs549994697       rs550900006       rs551027855       rs551117148       rs551439619       rs551768607       rs551818382       rs551917746       rs553096208       rs553128042       rs553217940       rs553378951       rs555654024       rs555827160       rs556035722       rs556309732       rs556446414       rs556846068       rs557363663       rs557933950       rs558095659       rs558224861       rs558361547       rs558751050       rs558914760       rs559881826       rs560929101       rs561066382       rs561111841       rs561576334       rs561707961       rs562247060       rs562912388       rs563316951       rs564667202       rs565236966       rs565514926       rs566182862       rs566320533       rs566645860       rs566677613       rs566858875       rs567405322       rs567774559       rs568511648       rs569252368       rs569649936       rs571570788       rs571726170       rs572001134       rs572015400       rs573491651       rs574645132       rs574771696       rs575078838       rs576290335       rs576293231       rs577105411       rs577217418       rs577315387       rs577930917       rs745573436       rs745616785       rs746149212       rs746822337       rs747025343       rs747585650       rs748408053       rs748555956       rs748726244       rs748822450       rs749593326       rs750670878       rs750733546       rs751314873       rs751358894       rs751423573       rs751576736       rs752043059       rs752587500       rs752780075       rs752837074       rs753542445       rs754081379       rs754170938       rs755011534       rs755102571       rs756262789       rs756308168       rs756729147       rs756986980       rs757601147       rs757691164       rs758285225       rs758786634       rs759465590       rs759569570       rs760045882       rs760732465       rs760822518       rs761261925       rs761285608       rs761565778       rs761973517       rs761989899       rs762636048       rs762727686       rs763136493       rs763591515       rs763717314       rs764246207       rs765301920       rs765384813       rs765409656       rs765442640       rs765471634       rs766232907       rs766250979       rs766695991       rs767375293       rs767419838       rs768649599       rs769355426       rs769369882       rs769991894       rs770254328       rs770527256       rs770693008       rs771328827       rs771434382       rs771520267       rs771817525       rs771867229       rs772592430       rs772850428       rs772866388       rs773456224       rs773757813       rs773874978       rs774768925       rs775088233       rs776141166       rs776159089       rs776784820       rs776802733       rs777317491       rs778167852       rs778610995       rs779373980       rs779548625       rs781126850       rs781375434       rs781684749       rs869279394      

基因表达

基因表达

PPIA基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TTGTCCATGGCAAATGCTG
59
CGAGATCCAGTCACTCAGTC
60
AGACTGAGTGGTTGGATGG
59
GATCTTCTTGCTGGTCTTGC
59
TATGTGTCAGGGTGGTGAC
59
CGTATGCTTTAGGATGAAGTTCTC
59
CTCCTTTGAGCTGTTTGCA
59
GGAACCCTTATAACCAAATCCT
58
CTCCTTTGAGCTGTTTGCA
59
GGAACCCTTATAACCAAATCCT
58
AGACTGAGTGGTTGGATGG
59
ATCTTCTTGCTGGTCTTGC
58
AGACTGAGTGGTTGGATGG
59
GATCTTCTTGCTGGTCTTGC
59
CTCTCAAAGCAGTGTGAGG
58
CCCTCAAGAAGCTTATAACTCTC
59
AGACTGAGTGGTTGGATGG
59
GATCTTCTTGCTGGTCTTGC
59
GTTTATGTGTCAGGGTGGTG
58
CGTATGCTTTAGGATGAAGTTCTC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

PPIA基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

PPIA基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000413
C9J5S7(UniProtKB)
IEA
GO:0003755
C9J5S7(UniProtKB)
IEA
GO:0006457
C9J5S7(UniProtKB)
IEA
GO:0000413
F8WE65(UniProtKB)
IEA
GO:0003755
F8WE65(UniProtKB)
IEA
GO:0006457
F8WE65(UniProtKB)
IEA
GO:0000413
P62937(UniProtKB)
IDA
GO:0003755
P62937(UniProtKB)
IDA
GO:0005515
P62937(UniProtKB)
IPI
GO:0005515
P62937(UniProtKB)
IPI
GO:0005515
P62937(UniProtKB)
IPI
GO:0005515
P62937(UniProtKB)
IPI
GO:0005515
P62937(UniProtKB)
IPI
GO:0005515
P62937(UniProtKB)
IPI
GO:0005515
P62937(UniProtKB)
IPI
GO:0005515
P62937(UniProtKB)
IPI
GO:0005576
P62937(UniProtKB)
TAS
GO:0005576
P62937(UniProtKB)
TAS
GO:0005576
P62937(UniProtKB)
TAS
GO:0005576
P62937(UniProtKB)
TAS
GO:0005576
P62937(UniProtKB)
TAS
GO:0005576
P62937(UniProtKB)
TAS
GO:0005576
P62937(UniProtKB)
TAS
GO:0005576
P62937(UniProtKB)
TAS
GO:0005576
P62937(UniProtKB)
TAS
GO:0005576
P62937(UniProtKB)
TAS
GO:0005576
P62937(UniProtKB)
TAS
GO:0005615
P62937(UniProtKB)
IDA
GO:0005634
P62937(UniProtKB)
IDA
GO:0005829
P62937(UniProtKB)
IDA
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005829
P62937(UniProtKB)
TAS
GO:0005925
P62937(UniProtKB)
IDA
GO:0006278
P62937(UniProtKB)
TAS
GO:0006278
P62937(UniProtKB)
TAS
GO:0006278
P62937(UniProtKB)
TAS
GO:0006278
P62937(UniProtKB)
TAS
GO:0006457
P62937(UniProtKB)
TAS
GO:0006457
P62937(UniProtKB)
TAS
GO:0016020
P62937(UniProtKB)
IDA
GO:0019058
P62937(UniProtKB)
TAS
GO:0019061
P62937(UniProtKB)
TAS
GO:0019061
P62937(UniProtKB)
TAS
GO:0019064
P62937(UniProtKB)
TAS
GO:0019068
P62937(UniProtKB)
TAS
GO:0019076
P62937(UniProtKB)
TAS
GO:0030260
P62937(UniProtKB)
TAS
GO:0034389
P62937(UniProtKB)
IMP
GO:0042277
P62937(UniProtKB)
IEA
GO:0044822
P62937(UniProtKB)
IDA
GO:0044822
P62937(UniProtKB)
IDA
GO:0045069
P62937(UniProtKB)
IMP
GO:0045069
P62937(UniProtKB)
TAS
GO:0045070
P62937(UniProtKB)
IMP
GO:0046790
P62937(UniProtKB)
NAS
GO:0050714
P62937(UniProtKB)
IMP
GO:0050900
P62937(UniProtKB)
TAS
GO:0051082
P62937(UniProtKB)
TAS
GO:0070062
P62937(UniProtKB)
IDA
GO:0070062
P62937(UniProtKB)
IDA
GO:0070062
P62937(UniProtKB)
IDA
GO:0070062
P62937(UniProtKB)
IDA
GO:0070062
P62937(UniProtKB)
IDA
GO:0075713
P62937(UniProtKB)
TAS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控PPIA基因的相关microRNA：      显示全部miRNA

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Non-Small Cell Lung Carcinoma 0.120814326 4 0 BeFree_CTD_human
Neoplasm Metastasis 0.120814326 4 0 BeFree_CTD_human
Squamous cell carcinoma 0.12 1 0 CTD_human
Mouth Neoplasms 0.12 1 0 CTD_human
Peripheral Neuropathy 0.12 1 0 CTD_human
Stomach Neoplasms 0.12 1 0 CTD_human
Epilepsy 0.08 1 0 RGD
HIV Infections 0.012062995 27 2 BeFree_GAD
Atherosclerosis 0.005905708 4 0 BeFree_GAD_LHGDN
Infection 0.0054487 2 0 LHGDN
Endometrial Neoplasms 0.002995792 2 0 BeFree_LHGDN
Lung Neoplasms 0.002995792 2 0 BeFree_LHGDN
Small cell carcinoma of lung 0.002995792 1 0 BeFree_LHGDN
Vascular Diseases 0.00272435 1 0 LHGDN
Severe Acute Respiratory Syndrome 0.00272435 1 0 LHGDN
Mammary Neoplasms 0.00272435 1 0 LHGDN
Hepatitis C 0.001357209 5 0 BeFree
Virus Diseases 0.001085767 4 0 BeFree
Carcinogenesis 0.001085767 4 0 BeFree
Arteriosclerosis 0.000814326 3 0 BeFree
Rheumatoid Arthritis 0.000814326 3 0 BeFree
Liver carcinoma 0.000814326 3 0 BeFree
Asthma 0.000542884 2 0 BeFree
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Influenza 0.000542884 2 0 BeFree
Cholangiocarcinoma 0.000542884 2 0 BeFree
Pancreatic carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of lung 0.000542884 2 0 BeFree
Solid tumour 0.000542884 2 0 BeFree
Malignant neoplasm of pancreas 0.000542884 2 0 BeFree
Endometrial Carcinoma 0.000542884 2 0 BeFree
Prostate carcinoma 0.000542884 2 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Carcinoma of lung 0.000542884 2 0 BeFree
Acquired Immunodeficiency Syndrome 0.000271442 1 0 BeFree
Amyotrophic Lateral Sclerosis 0.000271442 1 0 BeFree
Aortic Aneurysm 0.000271442 1 0 BeFree
Malignant neoplasm of endometrium 0.000271442 1 0 BeFree
Diabetes 0.000271442 1 0 BeFree
Diabetes Mellitus 0.000271442 1 0 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.000271442 1 0 BeFree
Glioblastoma 0.000271442 1 0 BeFree
Pulmonary Hypertension 0.000271442 1 0 BeFree
leukemia 0.000271442 1 0 BeFree
Malignant neoplasm of stomach 0.000271442 1 0 BeFree
Schizophrenia 0.000271442 1 0 BeFree
Right Ventricular Hypertrophy 0.000271442 1 0 BeFree
Aortic Aneurysm, Abdominal 0.000271442 1 0 BeFree
Gallbladder Carcinoma 0.000271442 1 0 BeFree
bone destruction 0.000271442 1 0 BeFree
Vesicular Stomatitis 0.000271442 1 0 BeFree
Adenocarcinoma of pancreas 0.000271442 1 0 BeFree
Superficial ulcer 0.000271442 1 0 BeFree
Early gastric cancer 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Progressive Neoplastic Disease 0.000271442 1 0 BeFree
Refractory cancer 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lymph node 0.000271442 1 0 BeFree
Stomach Carcinoma 0.000271442 1 0 BeFree
Inflammatory disorder 0.000271442 1 0 BeFree
Pancreatic Ductal Adenocarcinoma 0.000271442 1 0 BeFree
Uterine Corpus Cancer 0.000271442 1 0 BeFree
Progressive cGVHD 0.000271442 1 0 BeFree

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