ASIC3(acid sensing (proton gated) ion channel 3)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

7q35
基因染色体位置图

基因简述

基因简述

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

[中文简述(自动翻译):]  该基因编码的degenerin /上皮钠通道（DEG / ENaC的）超家族的一个成员。这个家族的成员是包含细胞内的N和C末端，两个疏水跨膜区和一个大型的胞外环，它与保守的间距许多半胱氨酸残基阿米洛利敏感的钠通道。由该基因编码的构件是酸传感器，并在检测持续pH变化可发挥重要的作用。此外，这种构件和酸传感之间的异关联（质子门控）离子通道2已经观察到钆敏感质子门控通道。可变剪接转录物变体已有描述。 [由RefSeq的，2012年2月提供]

OMIM数据库中对ASIC3基因的介绍     Wikipedia数据库中对ASIC3基因的介绍

基因序列

基因序列

ASIC3基因的碱基序列：[NCBI]

基因突变

基因突变

ASIC3基因的碱基突变：           显示全部snp
rs4148854       rs6979693       rs11770520       rs71712832       rs79313306       rs113467739       rs115008460       rs116563575       rs117428721       rs140363413       rs144593148       rs145451109       rs145666848       rs145692603       rs146728380       rs148961532       rs181014455       rs181279604       rs181914005       rs184852039       rs185921869       rs188149518       rs190796012       rs372042876       rs528152751       rs529202338       rs529466792       rs530641195       rs534681639       rs534739402       rs534740888       rs535467313       rs536146974       rs537091104       rs537151579       rs540020024       rs540081940      
rs542027693       rs542917891       rs543179120       rs544282149       rs544988808       rs547966141       rs549345303       rs549646427       rs550058516       rs553212668       rs553298218       rs555751376       rs556837417       rs557141554       rs557425906       rs557649696       rs557745284       rs560864392       rs562467952       rs563419186       rs564897814       rs564960194       rs565997750       rs566304553       rs570238125       rs571066321       rs572392227       rs576703347       rs577411755       rs577747453       rs1864545       rs2288645       rs2288646       rs6944382       rs6978641       rs10255526       rs11977275       rs35681353       rs57236379       rs58134191       rs62001891       rs62001892       rs62001893       rs62001896       rs62001897       rs74865567       rs75042382       rs75517657       rs78812721       rs111784048       rs112149514       rs114024820       rs114063044       rs114216747       rs114314698       rs114837285       rs115179904       rs115701115       rs116014003       rs116038852       rs116102133       rs116500016       rs117806186       rs138091625       rs138115329       rs138242995       rs138872415       rs139085042       rs139231811       rs139546962       rs139974311       rs140048490       rs140593742       rs141286058       rs141344838       rs141778240       rs141877615       rs141892433       rs141910870       rs141998060       rs142151024       rs142655334       rs143167179       rs143343782       rs143427620       rs143756561       rs144198212       rs144223292       rs144330560       rs145339468       rs145490470       rs145629681       rs145775749       rs146309688       rs146916223       rs147577517       rs147943737       rs147990189       rs148067461       rs148467100       rs148801982       rs149180925       rs149333074       rs150091812       rs150230080       rs150462572       rs150496362       rs151199388       rs151249670       rs181703160       rs182143151       rs182679581       rs184252418       rs186151285       rs187345635       rs187671745       rs187900850       rs188986606       rs190525135       rs190713987       rs192297262       rs192889290       rs193119056       rs199642384       rs199755425       rs199876394       rs200114588       rs200274938       rs200298732       rs200391606       rs200466021       rs200502346       rs200524358       rs200595590       rs200735941       rs200963043       rs200977005       rs201004181       rs201063435       rs201104214       rs201153989       rs201230822       rs201385813       rs201478022       rs201529251       rs201646704       rs201752054       rs201843515       rs202074862       rs202075625       rs202138681       rs367577120       rs367609780       rs368143619       rs368178438       rs368220067       rs368295863       rs368421125       rs368616729       rs368675783       rs368757639       rs368955092       rs368976515       rs369122567       rs369454932       rs369545663       rs369604091       rs369864194       rs370089221       rs370096272       rs370252165       rs370369500       rs370429790       rs370705676       rs370728181       rs370877491       rs371018510       rs371031278       rs371256322       rs371376038       rs371490651       rs371968452       rs371986350       rs372164671       rs372370126       rs372397326       rs372505837       rs372652476       rs373184803       rs373238463       rs373281304       rs373363411       rs373729594       rs373975342       rs374163546       rs374362547       rs374468932       rs374555174       rs374565191       rs374603867       rs374624215       rs374662475       rs374817631       rs375107350       rs375324927       rs375363889       rs375784138       rs375983305       rs376432727       rs376492437       rs376574520       rs376911803       rs377143500       rs377265988       rs377323790       rs377388928       rs527284795       rs527543284       rs527873441       rs528157488       rs528457972       rs528719557       rs531127841       rs532400592       rs532610275       rs532748577       rs533277404       rs533530797       rs533566184       rs533590116       rs534725854       rs535528995       rs535538081       rs535804340       rs536371738       rs536433508       rs537170320       rs537752884       rs538819179       rs540130534       rs540602741       rs540797382       rs540858696       rs541056759       rs541273309       rs543890889       rs543969910       rs545107973       rs546310892       rs547109781       rs547880253       rs547966092       rs548026567       rs548400225       rs548452200       rs548933934       rs549463375       rs549586118       rs549763020       rs550734437       rs551494542       rs551649355       rs553368532       rs554289599       rs554483671       rs554507762       rs554947323       rs555164678       rs555421912       rs555665814       rs556245886       rs557531105       rs557855606       rs557865888       rs558495765       rs558909266       rs558929874       rs559456655       rs559523045       rs559666713       rs560490967       rs560534800       rs561020971       rs561113955       rs561550514       rs563747590       rs563963132       rs564002499       rs564090081       rs564855436       rs564981317       rs565387190       rs565807969       rs565809530       rs566660382       rs567451223       rs567683238       rs567716483       rs568372040       rs569621626       rs570125637       rs570186016       rs571132120       rs571667129       rs571908824       rs572136813       rs572220303       rs573148921       rs573212340       rs575137638       rs575250733       rs575307125       rs575743611       rs576565288       rs577646273       rs577775237       rs577819142       rs745324943       rs745498469       rs745577884       rs745699835       rs745824246       rs745862920       rs745903993       rs746064840       rs746112554       rs746143262       rs746191573       rs746380842       rs746657424       rs746740072       rs746968141       rs746978622       rs747012626       rs747127061       rs747134672       rs747277462       rs747352796       rs747413498       rs747505228       rs747509313       rs747527437       rs747610290       rs747950910       rs747968925       rs748088218       rs748318095       rs748368955       rs748579784       rs748626648       rs748643819       rs748731503       rs748736458       rs748986630       rs749006302       rs749134100       rs749222515       rs749253843       rs749323444       rs749455807       rs749495490       rs749528853       rs749611740       rs749621222       rs749910921       rs750094907       rs750271120       rs750351543       rs750380438       rs750476920       rs750506413       rs750567036       rs750604015       rs750619018       rs750631169       rs750777531       rs750927193       rs750942178       rs751066355       rs751224977       rs751253272       rs751312126       rs751454802       rs751508282       rs751732928       rs751825234       rs751841571       rs752000897       rs752155567       rs752166306       rs752199449       rs752207683       rs752303895       rs752334952       rs752406148       rs752414495       rs752575430       rs752605925       rs752631288       rs752648072       rs752875882       rs752962315       rs753138445       rs753440843       rs753466031       rs753477836       rs753527375       rs753567611       rs753571682       rs753806600       rs754009304       rs754042054       rs754077943       rs754153163       rs754262390       rs754341147       rs754357547       rs754483769       rs754664943       rs754724761       rs754745451       rs754949155       rs754994322       rs755203966       rs755268856       rs755276320       rs755496371       rs755616788       rs755617018       rs755778227       rs755894575       rs755954520       rs756159075       rs756464637       rs756481074       rs756493982       rs756627669       rs756818785       rs756905170       rs756979055       rs757016942       rs757151006       rs757184564       rs757238831       rs757336992       rs757338644       rs757431074       rs757556976       rs757609373       rs757647609       rs757655509       rs757667487       rs757740440       rs757766302       rs757767256       rs757817730       rs757875390       rs758125859       rs758213899       rs758417400       rs758486487       rs758519517       rs758704856       rs758707703       rs758755360       rs758830431       rs758833330       rs758973350       rs759045801       rs759091268       rs759146789       rs759214498       rs759243836       rs759265724       rs759303666       rs759328237       rs759343965       rs759431686       rs759457261       rs759506067       rs759568152       rs759793510       rs759941398       rs760007950       rs760106953       rs760138830       rs760192489       rs760335076       rs760374529       rs760460254       rs760474500       rs760573829       rs760597883       rs760614484       rs760839346       rs760874999       rs760901541       rs761024340       rs761211712       rs761253243       rs761260925       rs761362106       rs761527177       rs761664922       rs761713517       rs761796285       rs761995722       rs762062532       rs762096155       rs762210602       rs762448258       rs762479306       rs762486363       rs762585526       rs762660247       rs762670261       rs762732491       rs762786553       rs762969627       rs762984808       rs763166166       rs763173394       rs763239303       rs763327978       rs763497531       rs763498860       rs763507427       rs763510986       rs763966968       rs763968874       rs764215929       rs764339992       rs764341073       rs764374817       rs764493969       rs764538965       rs764641723       rs764661934       rs764745996       rs764927092       rs764943608       rs765126744       rs765175405       rs765259456       rs765378163       rs765427661       rs765640850       rs765708813       rs766046016       rs766078054       rs766089854       rs766347273       rs766451637       rs766707655       rs766821943       rs766846943       rs766863604       rs766867558       rs767102339       rs767208409       rs767227454       rs767242495       rs767281465       rs767321824       rs767450510       rs767508446       rs767557099       rs767611755       rs767695870       rs767757693       rs767851914       rs767906753       rs767929076       rs768140748       rs768140923       rs768612148       rs768614368       rs768630829       rs768713899       rs768724785       rs768764308       rs768911847       rs768921329       rs769000491       rs769116431       rs769209323       rs769267978       rs769278125       rs769392544       rs769444157       rs769451008       rs769466881       rs769745881       rs769862915       rs769879323       rs769888171       rs770040253       rs770093614       rs770361715       rs770372283       rs770381295       rs770579486       rs770645833       rs770758431       rs770779744       rs770813334       rs770816060       rs770839572       rs771076035       rs771099965       rs771216658       rs771422088       rs771498570       rs771569606       rs771616059       rs771618030       rs771697402       rs771701071       rs771765736       rs771834367       rs771928193       rs772144675       rs772218549       rs772300980       rs772364969       rs772460301       rs772552691       rs772569026       rs772658811       rs772676029       rs772678516       rs773135045       rs773224920       rs773323287       rs773411552       rs773415365       rs773505257       rs773537442       rs773761947       rs773763765       rs773933035       rs774020487       rs774022451       rs774073299       rs774339815       rs774456289       rs774467659       rs774545752       rs774641603       rs774652716       rs774740666       rs774815539       rs774850055       rs774936830       rs775017528       rs775024711       rs775138378       rs775143877       rs775284131       rs775437228       rs775473297       rs775473408       rs775509865       rs775594172       rs775684651       rs775716985       rs775852854       rs775853512       rs775965570       rs775971355       rs775981119       rs776059505       rs776173541       rs776358418       rs776359742       rs776621322       rs776642831       rs776742446       rs776743675       rs776943061       rs777105957       rs777114538       rs777308679       rs777322812       rs777470508       rs777507436       rs777598948       rs777603969       rs777615276       rs777980557       rs778006863       rs778069551       rs778117224       rs778287976       rs778336098       rs778361039       rs778369843       rs778542786       rs778553914       rs778659760       rs778782539       rs778827550       rs778829040       rs778835123       rs779129347       rs779149324       rs779319354       rs779690223       rs779775702       rs779816600       rs779832567       rs779907035       rs780028463       rs780168305       rs780187832       rs780246837       rs780271082       rs780339201       rs780433423       rs780454214       rs780558197       rs780659806       rs780939028       rs781030978       rs781338779       rs781382564       rs781472209       rs781487310       rs781668643       rs781708441       rs781736113      

基因表达

基因表达

ASIC3基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CGAATGGTGTACATGCCAG
59
CGAAGCATGGCATCTATGG
59
ACATCTTCTTTGAGGCCCT
59
CAATGTCACCAAGCAGCTC
60
TATTTCTGGAACCGACAGCA
60
GACAGCAGGTCTAGAGCTG
60
CCTCCCTATACCCTTATGGG
58
GAAGCATGGCATCTATGGC
59
CGAATGGTGTACATGCCAG
59
GAAGCATGGCATCTATGGC
59
ACATCTTCTTTGAGGCCCTC
60
CAATGTCACCAAGCAGCTC
60
CTTCACCACGATCTTCACC
58
TAGTAGTGGTGAGCAGCTC
59
GAGGGACAATGAGGAGACC
59
GAAACAAAGGTCTGGTAGCC
59
GACATCTTCTTTGAGGCCCT
60
CAATGTCACCAAGCAGCTC
60
ACATCTTCTTTGAGGCCCTC
60
CAATGTCACCAAGCAGCTC
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

ASIC3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

ASIC3基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005272
H7C4W0(UniProtKB)
IEA
GO:0016021
H7C4W0(UniProtKB)
IEA
GO:0035725
H7C4W0(UniProtKB)
IEA
GO:0005272
H7C5N6(UniProtKB)
IEA
GO:0016021
H7C5N6(UniProtKB)
IEA
GO:0035725
H7C5N6(UniProtKB)
IEA
GO:0005261
Q9UHC3(UniProtKB)
TAS
GO:0005272
Q9UHC3(UniProtKB)
TAS
GO:0005737
Q9UHC3(UniProtKB)
IEA
GO:0005886
Q9UHC3(UniProtKB)
TAS
GO:0005887
Q9UHC3(UniProtKB)
IEA
GO:0005887
Q9UHC3(UniProtKB)
IEA
GO:0006810
Q9UHC3(UniProtKB)
TAS
GO:0007165
Q9UHC3(UniProtKB)
TAS
GO:0007600
Q9UHC3(UniProtKB)
TAS
GO:0009408
Q9UHC3(UniProtKB)
IEA
GO:0010447
Q9UHC3(UniProtKB)
IEA
GO:0010447
Q9UHC3(UniProtKB)
IEA
GO:0030165
Q9UHC3(UniProtKB)
IEA
GO:0034220
Q9UHC3(UniProtKB)
TAS
GO:0035725
Q9UHC3(UniProtKB)
IEA
GO:0042930
Q9UHC3(UniProtKB)
IEA
GO:0042931
Q9UHC3(UniProtKB)
IEA
GO:0044736
Q9UHC3(UniProtKB)
TAS
GO:0050915
Q9UHC3(UniProtKB)
IMP
GO:0050965
Q9UHC3(UniProtKB)
IEA
GO:0050966
Q9UHC3(UniProtKB)
IEA
GO:0050968
Q9UHC3(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控ASIC3基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Inflammation 0.12 1 0 CTD_human
Hypertensive disease 0.002367032 1 0 GAD
Insulin Resistance 0.002367032 1 0 GAD
Coronary Arteriosclerosis 0.000542884 2 0 BeFree
Fatigue 0.000542884 2 0 BeFree
Myocardial Ischemia 0.000542884 2 0 BeFree
Arthritis 0.000271442 1 0 BeFree
Rheumatoid Arthritis 0.000271442 1 0 BeFree
Pressure Ulcer 0.000271442 1 0 BeFree
Fibromyalgia 0.000271442 1 0 BeFree
Hyperalgesia 0.000271442 1 0 BeFree
Myalgia 0.000271442 1 0 BeFree
Inflammatory pain 0.000271442 1 0 BeFree
Autonomic nervous system imbalance 0.000271442 1 0 BeFree
Impaired glucose tolerance 0.000271442 1 0 BeFree
Hyperalgesia, Primary 0.000271442 1 0 BeFree

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