Home LiteratureArticle Details
PMID: 9562972 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr.

Molecular medicine (Cambridge, Mass.) ·Vol. 4 ·No. 3 ·1998-03-00 ·Pages 138-43

Bukrinsky MI, Haffar OK

Abstract

暂无摘要

MeSH Terms
Cell Nucleus/metabolism,virology Gene Products, gag/metabolism Gene Products, vpr/metabolism HIV Antigens/metabolism HIV-1/metabolism Humans Nuclear Localization Signals/physiology Viral Proteins gag Gene Products, Human Immunodeficiency Virus vpr Gene Products, Human Immunodeficiency Virus
Chemicals
Gene Products, gag Gene Products, vpr HIV Antigens Nuclear Localization Signals Viral Proteins gag Gene Products, Human Immunodeficiency Virus p17 protein, Human Immunodeficiency Virus Type 1 vpr Gene Products, Human Immunodeficiency Virus
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bukrinsky M I
Picower Institute for Medical Research, Manhasset, NY 11030, USA. mbukrinsky@picower.edu
Haffar O K
References (48)
48 references, click to expand
  1. Integration is not necessary for expression of human immunodeficiency virus type 1 protein products.
    J Virol. 1990 May;64(5):2421-5 PMID: 2157898
  2. The effects of variations in the number and sequence of targeting signals on nuclear uptake.
    J Cell Biol. 1988 Oct;107(4):1279-87 PMID: 3170630
  3. Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import.
    Cell. 1991 Sep 6;66(5):837-47 PMID: 1653647
  4. Human major HSP70 protein complements the localization and functional defects of cytoplasmic mutant SV40 T antigen in Swiss 3T3 mouse fibroblast cells.
    Genes Dev. 1991 Dec;5(12A):2235-44 PMID: 1748281
  5. Nuclear targeting sequences--a consensus?
    Trends Biochem Sci. 1991 Dec;16(12):478-81 PMID: 1664152
  6. The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate.
    Mol Cell Biol. 1992 May;12(5):2186-92 PMID: 1569948
  7. Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.
    Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6580-4 PMID: 1631159
  8. 70-kDa heat-shock cognate protein colocalizes with karyophilic proteins into the nucleus during their transport in vitro.
    Exp Cell Res. 1993 May;206(1):134-42 PMID: 8482354
  9. Integration of murine leukemia virus DNA depends on mitosis.
    EMBO J. 1993 May;12(5):2099-108 PMID: 8491198
  10. HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import.
    EMBO J. 1997 Aug 1;16(15):4531-9 PMID: 9303297
  11. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.
    Nat Biotechnol. 1997 Sep;15(9):871-5 PMID: 9306402
  12. HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection.
    Genes Dev. 1998 Jan 15;12(2):175-85 PMID: 9436978
  13. Viral protein R regulates nuclear import of the HIV-1 pre-integration complex.
    EMBO J. 1998 Feb 16;17(4):909-17 PMID: 9463369
  14. The glucocorticoid receptor type II complex is a target of the HIV-1 vpr gene product.
    Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3621-5 PMID: 7724608
  15. Human immunodeficiency virus type 1 DNA synthesis, integration, and efficient viral replication in growth-arrested T cells.
    J Virol. 1993 Jul;67(7):3969-77 PMID: 8099628
  16. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus.
    Nature. 1993 Oct 14;365(6447):661-3 PMID: 8413630
  17. A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells.
    Nature. 1993 Oct 14;365(6447):666-9 PMID: 8105392
  18. Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus.
    J Virol. 1994 Jan;68(1):510-6 PMID: 8254763
  19. Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor.
    J Cell Biol. 1993 Dec;123(6 Pt 2):1649-59 PMID: 8276887
  20. Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein.
    J Biol Chem. 1994 Jun 3;269(22):15577-82 PMID: 8195203
  21. The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes.
    Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6992-6 PMID: 8041734
  22. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.
    Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7311-5 PMID: 8041786
  23. Purification of a Ran-interacting protein that is required for protein import into the nucleus.
    Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):10212-6 PMID: 7937864
  24. Biochemical mechanism of HIV-1 Vpr function. Oligomerization mediated by the N-terminal domain.
    J Biol Chem. 1994 Dec 23;269(51):32131-7 PMID: 7798208
  25. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62.
    J Cell Biol. 1995 May;129(4):925-37 PMID: 7744965
  26. Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection.
    J Virol. 1995 Jun;69(6):3949-54 PMID: 7745752
  27. Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes.
    J Biol Chem. 1995 Jul 14;270(28):16499-502 PMID: 7622450
  28. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope.
    Curr Biol. 1995 Apr 1;5(4):383-92 PMID: 7627554
  29. The nuclear pore-targeting complex binds to nuclear pores after association with a karyophile.
    FEBS Lett. 1995 Jul 24;368(3):415-9 PMID: 7635189
  30. Assembly of the preprotein receptor MOM72/MAS70 into the protein import complex of the outer membrane of mitochondria.
    J Biol Chem. 1995 Nov 10;270(45):27116-21 PMID: 7592965
  31. Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr.
    J Virol. 1995 Dec;69(12):7909-16 PMID: 7494303
  32. Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins.
    Cell. 1995 Dec 1;83(5):683-92 PMID: 8521485
  33. Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import.
    J Virol. 1996 Feb;70(2):1027-32 PMID: 8551560
  34. Role of the nuclear transport factor p10 in nuclear import.
    Science. 1996 Apr 5;272(5258):120-2 PMID: 8600522
  35. Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly.
    Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3099-104 PMID: 8610175
  36. Importin provides a link between nuclear protein import and U snRNA export.
    Cell. 1996 Oct 4;87(1):21-32 PMID: 8858145
  37. Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation.
    Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11859-64 PMID: 8876228
  38. Identification of different roles for RanGDP and RanGTP in nuclear protein import.
    EMBO J. 1996 Oct 15;15(20):5584-94 PMID: 8896452
  39. In vivo nuclear transport kinetics in Saccharomyces cerevisiae: a role for heat shock protein 70 during targeting and translocation.
    J Cell Biol. 1996 Oct;135(2):329-39 PMID: 8896592
  40. RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import.
    J Cell Biol. 1996 Nov;135(3):559-69 PMID: 8909533
  41. Subcellular localization of avian sarcoma virus and human immunodeficiency virus type 1 integrases.
    J Virol. 1997 Jan;71(1):843-7 PMID: 8985428
  42. Differential expression and sequence-specific interaction of karyopherin alpha with nuclear localization sequences.
    J Biol Chem. 1997 Feb 14;272(7):4310-5 PMID: 9020149
  43. Nuclear protein import.
    Curr Opin Cell Biol. 1997 Jun;9(3):412-9 PMID: 9159081
  44. Infant-maternal HIV-specific immunoglobulin G1 antibody ratios as an indicator of vertical transmission.
    AIDS. 1997 Jul 15;11(9):1191-3 PMID: 9233473
  45. Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr.
    J Virol. 1997 Sep;71(9):6339-47 PMID: 9261351
  46. Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector.
    J Virol. 1997 Sep;71(9):6641-9 PMID: 9261386
  47. HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway.
    Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9825-30 PMID: 9275210
  48. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure.
    Cell. 1990 Apr 20;61(2):213-22 PMID: 2331748
Article Info
Journal
Molecular medicine (Cambridge, Mass.)
Abbr.
Mol Med
ISSN
1076-1551
Email
mbukrinsky@picower.edu
Published
1998-03-00
Pages
138-43
Language
English
Region
England
NLM ID
9501023
PMCID
PMC2230352
Subset
IM
Grants
NIAID NIH HHS · AI 33776 · United States
NIAID NIH HHS · AI 40386 · United States
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2