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PMID: 8022816 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 14 ·1994-07-05 ·Pages 6525-8

Aldrich CJ, Ljunggren HG, Van Kaer L, Ashton-Rickardt PG, Tonegawa S, Forman J

Abstract

Mice with a homozygous deletion in their Tap-1 gene (-/- mice) express very low levels of cell membrane major histocompatibility complex class I molecules and have < 1% peripheral CD8+ T cells. We show that these -/- mice but not their +/- littermates display strong primary syngeneic anti-H-2Kb and -Db-specific responses mediated by CD8+ T cells. These responses are augmented by in vivo priming. Further, -/- mice primed in vivo with H-2d alloantigens generate an anti-H-2d response which appears nearly as strong as that found in +/- littermates. Both -/- anti-H-2b and anti-H-2d T cells do not recognize target cells from Tap-1 -/- animals or Tap-2-deficient RMA-S cells. Thus, some CD8+ anti-self and alloreactive T cells can be selected in the absence of Tap proteins.

MeSH Terms
ATP Binding Cassette Transporter, Subfamily B, Member 2 ATP-Binding Cassette Transporters Animals Carrier Proteins/genetics,immunology Cytotoxicity, Immunologic H-2 Antigens/immunology Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Mutant Strains Neoplasm Transplantation Spleen/immunology T-Lymphocytes/immunology T-Lymphocytes, Cytotoxic/immunology beta 2-Microglobulin/genetics,immunology
Chemicals
ATP Binding Cassette Transporter, Subfamily B, Member 2 ATP-Binding Cassette Transporters Carrier Proteins H-2 Antigens TAP1 protein, human Tap1 protein, mouse beta 2-Microglobulin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Aldrich C J
Department of Microbiology, University of Texas Southwestern Medical Center at Dallas 75235-9048.
Ljunggren H G
Van Kaer L
Ashton-Rickardt P G
Tonegawa S
Forman J
References (42)
42 references, click to expand
  1. Empty MHC class I molecules come out in the cold.
    Nature. 1990 Aug 2;346(6283):476-80 PMID: 2198471
  2. Evidence for a differential avidity model of T cell selection in the thymus.
    Cell. 1994 Feb 25;76(4):651-63 PMID: 8124708
  3. Mutations in the major histocompatibility complex class I antigen-presenting groove affect both negative and positive selection of T cells.
    Eur J Immunol. 1990 Oct;20(10):2333-7 PMID: 2147006
  4. MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters.
    Nature. 1990 Dec 20-27;348(6303):738-41 PMID: 1979660
  5. Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters.
    Nature. 1990 Dec 20-27;348(6303):741-4 PMID: 2259383
  6. A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway.
    Nature. 1990 Dec 20-27;348(6303):744-7 PMID: 2259384
  7. Transport protein genes in the murine MHC: possible implications for antigen processing.
    Science. 1990 Dec 21;250(4988):1723-6 PMID: 2270487
  8. On the nature of peptides involved in T cell alloreactivity.
    J Exp Med. 1991 Nov 1;174(5):1059-71 PMID: 1940788
  9. Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter.
    Nature. 1991 Dec 19-26;354(6354):528-31 PMID: 1758495
  10. RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes.
    J Exp Med. 1992 Jan 1;175(1):163-8 PMID: 1309852
  11. An endogenous antigenic peptide bypasses the class I antigen presentation defect in RMA-S.
    J Exp Med. 1992 Mar 1;175(3):719-29 PMID: 1311017
  12. Ham-2 corrects the class I antigen-processing defect in RMA-S cells.
    Nature. 1992 Feb 13;355(6361):647-9 PMID: 1538753
  13. HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation.
    Science. 1992 Mar 6;255(5049):1264-6 PMID: 1546329
  14. Skin graft rejection by beta 2-microglobulin-deficient mice.
    J Exp Med. 1992 Apr 1;175(4):885-93 PMID: 1552287
  15. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides.
    Nature. 1992 Apr 2;356(6368):443-6 PMID: 1557127
  16. Cytotoxic T lymphocytes against the antigen-processing-defective RMA-S tumor cell line.
    Eur J Immunol. 1992 Jun;22(6):1639-42 PMID: 1601045
  17. Major histocompatibility complex (MHC)-encoded HAM2 is necessary for antigenic peptide loading onto class I MHC molecules.
    J Biol Chem. 1992 Jun 15;267(17):11669-72 PMID: 1339432
  18. Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.
    J Exp Med. 1985 Dec 1;162(6):1745-59 PMID: 3877776
  19. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy.
    Nature. 1986 Feb 20-26;319(6055):675-8 PMID: 3951539
  20. Role of self-peptides in positively selecting the T-cell repertoire.
    Nature. 1990 Mar 1;344(6261):65-7 PMID: 2304556
  21. The effects of MHC gene dosage and allelic variation on T cell receptor selection.
    Cell. 1990 Mar 23;60(6):1043-53 PMID: 2317862
  22. Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.
    Nature. 1990 Apr 19;344(6268):742-6 PMID: 2139497
  23. Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.
    Science. 1990 Jun 8;248(4960):1227-30 PMID: 2112266
  24. Immunodominant T cell epitope from signal sequence.
    Science. 1992 Aug 21;257(5073):1142 PMID: 1380726
  25. Functionally conformed free class I heavy chains exist on the surface of beta 2 microglobulin negative cells.
    J Exp Med. 1992 Sep 1;176(3):829-34 PMID: 1512546
  26. Cellular and peptide requirements for in vitro clonal deletion of immature thymocytes.
    Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9000-4 PMID: 1409596
  27. Major histocompatibility complex class I-specific and -restricted killing of beta 2-microglobulin-deficient cells by CD8+ cytotoxic T lymphocytes.
    Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11381-5 PMID: 1454824
  28. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells.
    Cell. 1992 Dec 24;71(7):1205-14 PMID: 1473153
  29. Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells.
    J Immunol. 1993 Mar 1;150(5):1763-71 PMID: 7679694
  30. Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen-presenting cells.
    Eur J Immunol. 1993 Mar;23(3):669-74 PMID: 8095457
  31. Highly lytic CD8+, alpha beta T-cell receptor cytotoxic T cells with major histocompatibility complex (MHC) class I antigen-directed cytotoxicity in beta 2-microglobulin, MHC class I-deficient mice.
    Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2837-41 PMID: 8464897
  32. Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.
    J Exp Med. 1993 May 1;177(5):1469-73 PMID: 8478616
  33. Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus.
    Cell. 1993 Jun 4;73(5):1041-9 PMID: 8500174
  34. Transporter-independent processing of HIV-1 envelope protein for recognition by CD8+ T cells.
    Nature. 1993 Jul 8;364(6433):158-61 PMID: 8321286
  35. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter.
    Science. 1993 Aug 6;261(5122):769-71 PMID: 8342042
  36. TAP2-defective RMA-S cells present Sendai virus antigen to cytotoxic T lymphocytes.
    Eur J Immunol. 1993 Aug;23(8):1796-801 PMID: 8393798
  37. Antigen processing mutant T2 cells present viral antigen restricted through H-2Kb.
    Eur J Immunol. 1993 Aug;23(8):1802-8 PMID: 8393799
  38. TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective.
    Cell. 1993 Aug 13;74(3):577-84 PMID: 8348620
  39. Peptide-induced changes in class I heavy chains alter allorecognition.
    J Immunol. 1993 Oct 15;151(8):3943-53 PMID: 8409378
  40. T cell receptor antagonist peptides induce positive selection.
    Cell. 1994 Jan 14;76(1):17-27 PMID: 8287475
  41. The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I.
    J Exp Med. 1994 Feb 1;179(2):661-72 PMID: 8294874
  42. Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.
    Proc Natl Acad Sci U S A. 1990 Aug;87(16):6186-90 PMID: 2117275
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.14.6525
Published
1994-07-05
Pages
6525-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC44235
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.91.14.6525 PMC Full Text View journal details
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