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PMID: 319006 Published · ppublish English Clinical Trial Controlled Clinical Trial Journal Article

Effect in bronchial asthma of a new beta-adrenergic blocking drug atenolol (ICI 66, 082).

European journal of clinical pharmacology ·Vol. 11 ·No. 1 ·1977-00-00 ·Pages 11-4

Boye NP, Vale JR

Abstract

The bronchial effect of intravenous atenolol (ICI 66.082) has been studied in a double-blind cross over trial in 10 patients with pronounced, labile bronchial asthama. A single i.v. dose of atenolol 3 mg. sufficient to cause a fall in heart rate and systolic blood pressure at rest, induced only a slight and clincially almost negligible impairment of ventilatory function. An ordinary therapeutic dose of salbutamol by inhalation far outweighed the bronchial effect of atenolol. The drug appears promising with regard to its cardio-selective properties.

MeSH Terms
Adult Aged Albuterol/pharmacology Asthma/physiopathology Atenolol/pharmacology Clinical Trials as Topic Drug Interactions Female Humans Male Middle Aged Propanolamines/pharmacology Respiratory Function Tests
Chemicals
Propanolamines Atenolol Albuterol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Boye N P
Vale J R
References (12)
12 references, click to expand
  1. Controlled study of atenolol in treatment of hypertension.
    Br Med J. 1975 May 17;2(5967):367-70 PMID: 236810
  2. Atenolol and bendrofluazide in hypertension.
    Br Med J. 1975 Oct 18;4(5989):133-5 PMID: 1104047
  3. Significance of effect of beta blockade on ventilatory function in normal and asthmatic subjects.
    Thorax. 1972 Sep;27(5):572-6 PMID: 5083724
  4. New approach to assessment of cardioselectivity of beta-blocking drugs.
    Br Med J. 1974 Nov 23;4(5942):444-7 PMID: 4425917
  5. Effect of a new beta-adrenergic blocking agent, ICI 66o82, on exercise haemodynamics and airway resistance in angina pectoris.
    Br Heart J. 1974 Dec;36(12):1194-1200 PMID: 4155316
  6. Comparison of the effects on airway conductance of a new selective beta-adrenergic blocking drug, atenolol, and propranolol in asthmatic subjects.
    Scand J Respir Dis. 1975;56(6):292-6 PMID: 1221496
  7. Comparative effects of beta adrenergic blocking drugs.
    Thorax. 1975 Feb;30(1):9-18 PMID: 235803
  8. A new type of cardioselective adrenoceptive blocking drug.
    Br J Pharmacol. 1973 Jun;48(2):340P PMID: 4147428
  9. Editorial: side effects of practolol.
    Br Med J. 1975 Jun 14;2(5971):577-8 PMID: 124197
  10. Effect of new beta-adrenergic blocking agent, Atenolol (Tenormin), on pain frequency, trinitrin consumption, and exercise ability.
    Br Med J. 1975 Jul 26;3(5977):195-7 PMID: 238716
  11. Effects of oxprenolol on the airways of normal and bronchitic subjects.
    Eur J Clin Pharmacol. 1976 Feb 6;9(4):259-63 PMID: 786691
  12. Side-effects of beta-adrenergic blocking drugs in asthmatics.
    Indian Heart J. 1972 Jun;24:Suppl 1:226-30 PMID: 4147277
Article Info
Journal
European journal of clinical pharmacology
Abbr.
Eur J Clin Pharmacol
ISSN
0031-6970
DOI
10.1007/BF00561781
Published
1977-00-00
Pages
11-4
Language
English
Region
Germany
NLM ID
1256165
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00561781 View journal details
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