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PMID: 23907135 Published · ppublish English Editorial Comment

mTOR, AMBRA1, and autophagy: an intricate relationship.

Cell cycle (Georgetown, Tex.) ·Vol. 12 ·No. 16 ·2013-08-15 ·Pages 2524-5

Nazio F, Cecconi F

Abstract

暂无摘要

Keywords
AMBRA1 TFEB ULK1 lysosome ubiquitylation
MeSH Terms
Adaptor Proteins, Signal Transducing/metabolism Autophagy Humans Intracellular Signaling Peptides and Proteins/chemistry Protein Serine-Threonine Kinases/chemistry TNF Receptor-Associated Factor 6/metabolism TOR Serine-Threonine Kinases/metabolism
Chemicals
Adaptor Proteins, Signal Transducing Intracellular Signaling Peptides and Proteins TNF Receptor-Associated Factor 6 Protein Serine-Threonine Kinases TOR Serine-Threonine Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nazio Francesca
Cecconi Francesco
References (8)
8 references, click to expand
  1. DAP1, a novel substrate of mTOR, negatively regulates autophagy.
    Curr Biol. 2010 Jun 22;20(12):1093-8 PMID: 20537536
  2. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
    EMBO J. 2012 Mar 7;31(5):1095-108 PMID: 22343943
  3. Molecular mechanisms of mTOR-mediated translational control.
    Nat Rev Mol Cell Biol. 2009 May;10(5):307-18 PMID: 19339977
  4. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.
    Mol Biol Cell. 2009 Apr;20(7):1981-91 PMID: 19211835
  5. mTOR signaling in growth control and disease.
    Cell. 2012 Apr 13;149(2):274-93 PMID: 22500797
  6. mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.
    Nat Cell Biol. 2013 Apr;15(4):406-16 PMID: 23524951
  7. The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy.
    J Cell Biol. 2010 Oct 4;191(1):155-68 PMID: 20921139
  8. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
    Science. 2011 Jun 10;332(6035):1317-22 PMID: 21659604
Article Info
Journal
Cell cycle (Georgetown, Tex.)
Abbr.
Cell Cycle
ISSN
1551-4005
DOI
10.4161/cc.25835
Published
2013-08-15
Epub
2013-00-30
Pages
2524-5
Language
English
Region
United States
NLM ID
101137841
PMCID
PMC3865034
Subset
IM
Grants
Telethon · GGP10225 · Italy
Corrections
CommentOn
PMID: 23524951
External Links
PubMed source DOI: 10.4161/cc.25835 PMC Full Text View journal details
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