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PMID: 2202722 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

SecB protein: a cytosolic export factor that associates with nascent exported proteins.

Journal of bioenergetics and biomembranes ·Vol. 22 ·No. 3 ·1990-06-00 ·Pages 337-51

Kumamoto CA

Abstract

Soluble factors participate in protein translocation across a variety of biological membranes. The Escherichia coli soluble protein SecB (the product of the secB gene) is involved in the export of periplasmic and outer membrane proteins. The isolation of secB mutations permitted the demonstration that SecB is required for rapid and efficient export of certain proteins. Consistent with the results of these genetic studies, purified SecB has been shown to stimulate protein translocation across E. coli inner membrane vesicles in vitro. This article presents a review of these past studies of SecB, speculation on the role of SecB in protein translocation, and a comparison of SecB and other factors, trigger factor and GroEL.

MeSH Terms
Bacterial Proteins/genetics,metabolism Base Sequence Biological Transport, Active Escherichia coli/metabolism Membrane Proteins/metabolism Molecular Sequence Data Mutation
Chemicals
Bacterial Proteins Membrane Proteins SecB protein, Bacteria
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kumamoto C A
Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111.
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Article Info
Journal
Journal of bioenergetics and biomembranes
Abbr.
J Bioenerg Biomembr
ISSN
0145-479X
DOI
10.1007/BF00763171
Published
1990-06-00
Pages
337-51
Language
English
Region
United States
NLM ID
7701859
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00763171 View journal details
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