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题目:: P-glycoprotein expression and chemosensitivity in highly purified fresh human gastrointestinal cancer cells.
作者:: Hotta(T),Tanimura(H),Tsunoda(T),Iwahashi(M),Tani(M),Noguchi(K),Mizobata(S),Arii(K),Terasawa(H),Nakamori(M),Yamaue(H)
状态:: 发布时间1999-06-23 , 更新时间 2013-11-21
期刊:: Hepatogastroenterology
摘要:: Colorectal cancer is one of the tumors most refractory to treatment by chemotherapy. One of the major problems associated with cancer chemotherapy is drug-resistance of tumor cells, and resistance to doxorubicin (DOX) is mainly due to the effect of P-glycoprotein. We have tried to prove the correlation between P-glycoprotein expression and DOX-sensitivity in highly purified fresh human colorectal cancer and, moreover, to prove the differentiation of P-glycoprotein expression between the different kinds of cancers, including gastric cancer.,The present study was designed to quantify P-glycoprotein expression by flow cytometry, and DOX-sensitivity by MTT assay in highly purified fresh human tumor cells obtained from 29 cancer patients including 13 colorectal cancers and 16 gastric cancers.,DOX-sensitivity decreased in proportion to P-glycoprotein expression in colorectal cancer. P-glycoprotein expression in colorectal cancer was higher than that in gastric cancer. Particularly, P-glycoprotein expression in colorectal cancer in the DOX low-sensitivity group was higher than in the DOX high-sensitivity group.,The chemotherapeutic management of patients with colorectal cancer might be more effective if we can circumvent the effect of P-glycoprotein.
语言:: eng
DOI:

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