ADCY1 (adenylate cyclase 1)
- symbol:
- ADCY1
- locus group:
- protein-coding gene
- location:
- 7p12.3
- gene_family:
- Adenylate cyclases
- alias symbol:
- AC1
- alias name:
- adenylyl cyclase subtype 1
- entrez id:
- 107
- ensembl gene id:
- ENSG00000164742
- ucsc gene id:
- uc003tne.5
- refseq accession:
- NM_021116
- hgnc_id:
- HGNC:232
- approved reserved:
- 1992-12-02
ADCY1（腺苷酸环化酶1）属于腺苷酸环化酶（AC）基因家族，该家族共有9个成员（ADCY1-9），它们共同编码腺苷酸环化酶，负责将ATP转化为第二信使cAMP，从而参与多种细胞信号传导通路。ADCY1主要在神经系统高表达，尤其是大脑皮层、海马和小脑，其产生的cAMP通过激活蛋白激酶A（PKA）调控神经元可塑性、学习记忆等关键功能。该基因定位于7p12.3，其蛋白产物具有典型的12次跨膜结构域和两个胞质催化结构域，受G蛋白偶联受体（GPCR）的Gsα亚基激活。ADCY1功能异常与多种神经系统疾病相关：突变可能导致智力障碍或精神分裂症风险增加，而阿尔茨海默病患者脑中常观察到ADCY1表达下降，这可能通过减少cAMP水平加剧tau蛋白过度磷酸化。过表达实验显示ADCY1能增强突触可塑性并改善记忆功能，但持续高活性可能导致异常神经兴奋；反之表达降低会损害长时程增强（LTP）效应。该基因还参与调节心脏功能，在心肌细胞中与β-肾上腺素受体信号偶联，其表达异常可能影响心脏收缩力。ADCY家族成员均含保守的催化核心区，但组织分布和调控机制各异：ADCY1对钙调蛋白敏感，而ADCY5主要受Gi蛋白抑制。最新研究发现ADCY1与疼痛感知相关，其抑制剂可能成为新型镇痛靶点。在癌症中，ADCY1表达变化与胶质瘤进展相关，可能通过影响CREB信号通路促进肿瘤侵袭。
This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
该基因编码的腺苷酸环化酶基因家族是主要在脑中表达的成员。该蛋白质是通过钙/钙调蛋白浓度调节并可能参与脑发育。选择性剪接结果在多个抄本变形。 [由RefSeq的，2013年8月提供]
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AAGACTGTCTGCTACCTGC
59
GGATCTGAACCTTGTCATCG
59
AAGACTGTCTGCTACCTGC
59
GGATCTGAACCTTGTCATCG
59
CCAGTTAACTTCAGTGCCA
58
GAATAATACTTCCCTTCCTTCCAC
59
GGAACATGGACCTCTACTACC
59
TGTAGAAGTCATTGAAGTTGGG
58
AAGGAGGACTTCCTGAAGC
59
CAGCAAACAGGATGCTCAC
59
TGCCATTGAGATGTTTGACG
59
ACATTGATGCCAACTCGGA
60
CAAGACTGTCTGCTACCTG
58
GATCTGAACCTTGTCATCGT
58
ATCCAGTTAACTTCAGTGCC
58
ATAATACTTCCCTTCCTTCCAC
57
CAAGACTGTCTGCTACCTG
58
GATCTGAACCTTGTCATCGT
58
AGATGAAGGAGGACTTCCTG
58
AACAGGATGCTCACATTGTC
58
基因本体信息
ADCY1基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
ADCY1基因的本体（GO）信息：
GO库代码
对应的蛋白质
来源代码
GO:0000166
C9J1J0 (UniProtKB)
IEA
GO:0005622
C9J1J0 (UniProtKB)
IEA
GO:0009190
C9J1J0 (UniProtKB)
IEA
GO:0016021
C9J1J0 (UniProtKB)
IEA
GO:0016849
C9J1J0 (UniProtKB)
IEA
GO:0035556
C9J1J0 (UniProtKB)
IEA
GO:0003091
Q08828 (UniProtKB)
TAS
GO:0004016
Q08828 (UniProtKB)
IBA
GO:0004016
Q08828 (UniProtKB)
TAS
GO:0005516
Q08828 (UniProtKB)
IEA
GO:0005524
Q08828 (UniProtKB)
IEA
GO:0005634
Q08828 (UniProtKB)
IEA
GO:0005737
Q08828 (UniProtKB)
ISS
GO:0005886
Q08828 (UniProtKB)
IDA
GO:0005886
Q08828 (UniProtKB)
TAS
GO:0005886
Q08828 (UniProtKB)
TAS
GO:0005886
Q08828 (UniProtKB)
TAS
GO:0005886
Q08828 (UniProtKB)
TAS
GO:0005886
Q08828 (UniProtKB)
TAS
GO:0005886
Q08828 (UniProtKB)
TAS
GO:0005886
Q08828 (UniProtKB)
TAS
GO:0005886
Q08828 (UniProtKB)
TAS
GO:0005886
Q08828 (UniProtKB)
TAS
GO:0005886
Q08828 (UniProtKB)
TAS
GO:0005886
Q08828 (UniProtKB)
TAS
GO:0005886
Q08828 (UniProtKB)
TAS
GO:0005886
Q08828 (UniProtKB)
TAS
GO:0005887
Q08828 (UniProtKB)
ISS
GO:0006171
Q08828 (UniProtKB)
ISS
GO:0006171
Q08828 (UniProtKB)
IBA
GO:0007189
Q08828 (UniProtKB)
ISS
GO:0007189
Q08828 (UniProtKB)
IBA
GO:0007189
Q08828 (UniProtKB)
TAS
GO:0007190
Q08828 (UniProtKB)
TAS
GO:0007193
Q08828 (UniProtKB)
IBA
GO:0007193
Q08828 (UniProtKB)
TAS
GO:0007409
Q08828 (UniProtKB)
IEA
GO:0007616
Q08828 (UniProtKB)
IEA
GO:0007623
Q08828 (UniProtKB)
IEA
GO:0008294
Q08828 (UniProtKB)
ISS
GO:0008294
Q08828 (UniProtKB)
NAS
GO:0010226
Q08828 (UniProtKB)
IEA
GO:0019933
Q08828 (UniProtKB)
ISS
GO:0019933
Q08828 (UniProtKB)
IBA
GO:0034199
Q08828 (UniProtKB)
TAS
GO:0042493
Q08828 (UniProtKB)
IEA
GO:0042752
Q08828 (UniProtKB)
ISS
GO:0045121
Q08828 (UniProtKB)
IEA
GO:0046872
Q08828 (UniProtKB)
IEA
GO:0070062
Q08828 (UniProtKB)
IDA
GO:0071277
Q08828 (UniProtKB)
ISS
GO:0071377
Q08828 (UniProtKB)
TAS
GO:1904322
Q08828 (UniProtKB)
ISS
| 名称 |
|---|
| 230 Purine metabolism [PATH:hsa00230] |
| 4015 Rap1 signaling pathway [PATH:hsa04015] |
| 4020 Calcium signaling pathway [PATH:hsa04020] |
| 4024 cAMP signaling pathway [PATH:hsa04024] |
| 4022 cGMP - PKG signaling pathway [PATH:hsa04022] |
| 4114 Oocyte meiosis [PATH:hsa04114] |
| 4540 Gap junction [PATH:hsa04540] |
| 4611 Platelet activation [PATH:hsa04611] |
| 4062 Chemokine signaling pathway [PATH:hsa04062] |
| 4911 Insulin secretion [PATH:hsa04911] |
| 4912 GnRH signaling pathway [PATH:hsa04912] |
| 4913 Ovarian Steroidogenesis [PATH:hsa04913] |
| 4915 Estrogen signaling pathway [PATH:hsa04915] |
| 4914 Progesterone-mediated oocyte maturation [PATH:hsa04914] |
| 4921 Oxytocin signaling pathway [PATH:hsa04921] |
| 4918 Thyroid hormone synthesis [PATH:hsa04918] |
| 4916 Melanogenesis [PATH:hsa04916] |
| 4261 Adrenergic signaling in cardiomyocytes [PATH:hsa04261] |
| 4270 Vascular smooth muscle contraction [PATH:hsa04270] |
| 4970 Salivary secretion [PATH:hsa04970] |
| 4971 Gastric acid secretion [PATH:hsa04971] |
| 4972 Pancreatic secretion [PATH:hsa04972] |
| 4976 Bile secretion [PATH:hsa04976] |
| 4724 Glutamatergic synapse [PATH:hsa04724] |
| 4727 GABAergic synapse [PATH:hsa04727] |
| 4725 Cholinergic synapse [PATH:hsa04725] |
| 4720 Long-term potentiation [PATH:hsa04720] |
| 4723 Retrograde endocannabinoid signaling [PATH:hsa04723] |
| 4750 Inflammatory mediator regulation of TRP channels [PATH:hsa04750] |
| 4713 Circadian entrainment [PATH:hsa04713] |
| 5200 Pathways in cancer [PATH:hsa05200] |
| 5032 Morphine addiction [PATH:hsa05032] |
| 5414 Dilated cardiomyopathy (DCM) [PATH:hsa05414] |
| 5166 HTLV-I infection [PATH:hsa05166] |
| 5146 Amoebiasis [PATH:hsa05146] |
| 5142 Chagas disease (American trypanosomiasis) [PATH:hsa05142] |
| 名称 |
|---|
| Activation of GABAB receptors |
| Activation of NMDA receptor upon glutamate binding and postsynaptic events |
| Adenylate cyclase activating pathway |
| Adenylate cyclase inhibitory pathway |
| Aquaporin-mediated transport |
| Ca-dependent events |
| Calmodulin induced events |
| CaM pathway |
| CREB phosphorylation through the activation of Adenylate Cyclase |
| DAG and IP3 signaling |
| DAP12 interactions |
| DAP12 signaling |
| Downstream signal transduction |
| Downstream signaling of activated FGFR1 |
| Downstream signaling of activated FGFR2 |
| Downstream signaling of activated FGFR3 |
| Downstream signaling of activated FGFR4 |
| EGFR interacts with phospholipase C-gamma |
| G alpha (i) signalling events |
| G alpha (s) signalling events |
| G alpha (z) signalling events |
| G-protein mediated events |
| GABA B receptor activation |
| GABA receptor activation |
| Glucagon signaling in metabolic regulation |
| GPCR downstream signaling |
| Hedgehog 'off' state |
| Immune System |
| Inhibition of adenylate cyclase pathway |
| Innate Immune System |
| Integration of energy metabolism |
| Metabolism |
| Neuronal System |
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell |
| NGF signalling via TRKA from the plasma membrane |
| Opioid Signalling |
| Phospholipase C-mediated cascade; FGFR2 |
| Phospholipase C-mediated cascade; FGFR3 |
| Phospholipase C-mediated cascade; FGFR4 |
| Phospholipase C-mediated cascade: FGFR1 |
| PKA activation |
| PKA activation in glucagon signalling |
| PKA-mediated phosphorylation of CREB |
| PLC beta mediated events |
| PLC-gamma1 signalling |
| PLCG1 events in ERBB2 signaling |
| Post NMDA receptor activation events |
| Signal Transduction |
| Signaling by EGFR |
| Signaling by ERBB2 |
| Signaling by FGFR |
| Signaling by FGFR1 |
| Signaling by FGFR2 |
| Signaling by FGFR3 |
| Signaling by FGFR4 |
| Signaling by GPCR |
| Signaling by Hedgehog |
| Signaling by PDGF |
| Signalling by NGF |
| Transmembrane transport of small molecules |
| Transmission across Chemical Synapses |
| Vasopressin regulates renal water homeostasis via Aquaporins |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Hyperactive behavior | 0.12 | 1 | 0 | CTD_human |
| Substance Withdrawal Syndrome | 0.12 | 1 | 0 | CTD_human |
| DEAFNESS, AUTOSOMAL RECESSIVE 44 | 0.12 | 0 | 1 | CLINVAR |
| Small cell carcinoma of lung | 0.12 | 1 | 0 | CTD_human |
| Weight Gain | 0.002367032 | 1 | 0 | GAD |
| Weight Gain Adverse Event | 0.002367032 | 1 | 0 | GAD |
| Mood Disorders | 0.000271442 | 1 | 0 | BeFree |
| Hyperthyroidism | 0.000271442 | 1 | 0 | BeFree |
| Alcoholic Intoxication, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Depressive disorder | 0.000271442 | 1 | 0 | BeFree |
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