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The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]
[中文简述(自动翻译):]  由该基因的功能编码同时作为磷酸二酯酶,其裂解磷酸二酯在寡核苷酸的5‘末端结合,和磷脂酶,其催化生产在细胞外液的溶血磷脂酸(LPA)的蛋白质。 LPA唤起生长因子样应答,包括细胞增殖和趋化性的刺激。这种基因产物刺激的肿瘤细胞的运动性和具有血管生成特性,并且其表达在几种癌上调。该基因产物被分泌并进一步处理,使生物活性形式。编码不同同种型的几个可变剪接转录物变体也已确定。 [由RefSeq的,2008年8月提供]
ENPP2基因(以及对应的蛋白质)的细胞分布位置:
ENPP2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Liver Cirrhosis, Experimental | 0.2 | 3 | 0 | CTD_human_RGD |
| Thyroid Neoplasm | 0.125720142 | 3 | 0 | BeFree_CTD_human_LHGDN |
| Neoplasm Metastasis | 0.120542884 | 3 | 0 | BeFree_CTD_human |
| Birth Weight | 0.12 | 1 | 0 | CTD_human |
| Hepatitis | 0.12 | 1 | 0 | CTD_human |
| Cadmium poisoning | 0.08 | 1 | 0 | RGD |
| Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
| Hyperalgesia | 0.08 | 1 | 0 | RGD |
| Drug-Induced Liver Injury | 0.08 | 1 | 0 | RGD |
| Mammary Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
| Hepatitis C | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Liver carcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Bulla | 0.00272435 | 1 | 0 | LHGDN |
| Hodgkin Disease | 0.00272435 | 1 | 0 | LHGDN |
| Liver Cirrhosis | 0.00272435 | 1 | 0 | LHGDN |
| Hepatitis C, Chronic | 0.00272435 | 1 | 0 | LHGDN |
| ovarian neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
| Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Goiter | 0.000542884 | 2 | 0 | BeFree |
| Thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Blood Coagulation Disorders | 0.000271442 | 1 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
| Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| Follicular thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Hypoalbuminemia | 0.000271442 | 1 | 0 | BeFree |
| Dyslipidemias | 0.000271442 | 1 | 0 | BeFree |
| Multiple malignancy | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Intraocular pressure disorder | 0.000271442 | 1 | 0 | BeFree |
| Aqueous Humor Disorders | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Spinocerebellar Ataxia Type 7 | 0.000271442 | 1 | 0 | BeFree |
| Endothelial dysfunction | 0.000271442 | 1 | 0 | BeFree |
| Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Benign Prostatic Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
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