TRIM3(tripartite motif containing 3)

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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11p15.5
基因染色体位置图

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  由该基因编码的蛋白质是三方基序(TRIM)家族的成员,也称为环指蛋白的“RING-B框-卷曲螺旋‘(RBCC)组。 TRIM的基序包括三个锌结合结构域,一个环,B框型1和B框2型,和一个卷曲螺旋区域。这种蛋白定位于细胞质细丝。它类似于大鼠蛋白,其为肌球蛋白V,一类参与细胞器的有针对性的运输肌球蛋白的尾部域中的特定的合作伙伴。大鼠蛋白还可以与α-辅肌动蛋白-4相互作用。因此,可以认为,这人蛋白质可能在肌球蛋白V型介导的货物运输的作用。编码相同同种型的可变剪接转录物变体也已确定。 [由RefSeq的,2008年7月提供]

TRIM3基因的碱基序列:[NCBI]
TRIM3基因的碱基突变:           显示全部snp
rs2723617       rs11601210       rs11603308       rs11605881       rs12294726       rs60487402       rs74055804       rs74055805       rs76916255       rs79663332       rs80160718       rs111604826       rs111646180       rs113209476       rs113625582       rs113764375       rs117106307       rs139033769       rs143283093       rs143896388       rs145361707       rs146563028       rs146652084       rs146890491       rs149154084       rs150448892       rs183957813       rs184016105       rs185180967       rs186942381       rs188342366       rs188998195       rs191405500       rs191515540       rs192939933       rs368647461       rs528196542      
rs528918313       rs530592686       rs530654511       rs531164964       rs532513527       rs535080237       rs536759628       rs541113706       rs541804095       rs542129818       rs543888034       rs546698623       rs548356261       rs552932799       rs553162698       rs558197421       rs559128250       rs559192373       rs559429260       rs563888817       rs563951036       rs565287476       rs565348922       rs565941351       rs569465156       rs570198532       rs570349815       rs572692511       rs574708082       rs574802645       rs576731196       rs577325384       rs10606       rs1057364       rs1060069       rs1060070       rs2303491       rs2306897       rs2344827       rs2555165       rs2555167       rs2634204       rs2723627       rs2723628       rs2723630       rs2723634       rs2723636       rs2723637       rs2723647       rs2723650       rs2723663       rs4758106       rs4758419       rs7123791       rs7129720       rs7932604       rs7933690       rs7936920       rs7945770       rs7950251       rs10128723       rs10665333       rs10839566       rs11040895       rs11040896       rs11040897       rs11601975       rs11603021       rs11605141       rs11605777       rs11607223       rs11607224       rs11821001       rs12419488       rs12807424       rs13343175       rs16913704       rs16913732       rs16913748       rs17821052       rs34253484       rs35717222       rs41275188       rs41275192       rs55664515       rs56024253       rs56046525       rs56146361       rs56716552       rs56752241       rs58121083       rs58262951       rs58804533       rs59935341       rs60616451       rs60959926       rs61148475       rs61613299       rs61758091       rs61876783       rs61876785       rs61876786       rs61876787       rs71470010       rs71490196       rs72898243       rs73400810       rs73400813       rs73400818       rs73400824       rs73400829       rs73400831       rs74053392       rs74053396       rs74053397       rs74053398       rs74053399       rs74053401       rs74055803       rs74431800       rs74466635       rs74471800       rs74910393       rs74961578       rs75098223       rs75321957       rs75322667       rs75343386       rs75363996       rs75553923       rs75729314       rs75760556       rs75784934       rs75833231       rs76070574       rs76115799       rs76337493       rs76906154       rs77177994       rs77383305       rs77678743       rs77730316       rs77737416       rs77786989       rs77814124       rs78095922       rs78296120       rs78406550       rs78515653       rs78619512       rs78663546       rs78667117       rs78811052       rs79199689       rs79355991       rs79627971       rs79771020       rs80119108       rs111269723       rs111290321       rs111380265       rs111522761       rs111604890       rs111623164       rs111821687       rs111832290       rs111998176       rs112139838       rs112260825       rs112489177       rs112508925       rs112670582       rs112673053       rs112833667       rs112882524       rs113111457       rs113113422       rs113232884       rs113523380       rs113552781       rs113596771       rs113790992       rs113883114       rs114241674       rs114388264       rs114701536       rs114906593       rs115071836       rs115111926       rs115283984       rs115913709       rs116021814       rs116192611       rs116277611       rs116462813       rs116616770       rs116630862       rs116989614       rs117190058       rs117255402       rs117376787       rs117547924       rs117733335       rs117778770       rs118074546       rs118170613       rs138000007       rs138144597       rs138160606       rs138183758       rs138201440       rs138225427       rs138392059       rs138411738       rs138494974       rs138597075       rs138600522       rs138673014       rs138688599       rs138883961       rs138963805       rs138970540       rs139143465       rs139185130       rs139291756       rs139690689       rs139706383       rs139735764       rs139782267       rs139873545       rs139889881       rs139906539       rs140019131       rs140026591       rs140345752       rs140488584       rs140581811       rs140688200       rs141102807       rs141194112       rs141209929       rs141315675       rs141337426       rs141388409       rs141446698       rs141555418       rs141650905       rs141904195       rs142025706       rs142278707       rs142562495       rs142644625       rs142721039       rs142846935       rs142997277       rs143396438       rs143408397       rs143432611       rs143479802       rs143625444       rs143703656       rs143814557       rs143831223       rs143918493       rs143939747       rs144053629       rs144175951       rs144312526       rs144485396       rs144496745       rs144521953       rs144532138       rs144660078       rs144748926       rs144792317       rs144869958       rs144893330       rs145092543       rs145167262       rs145197784       rs145293689       rs145658560       rs145666188       rs145866294       rs145877594       rs146086652       rs146306442       rs146379181       rs146535285       rs146553443       rs146671401       rs146779434       rs146874288       rs147004081       rs147132011       rs147152602       rs147289402       rs147338905       rs147394898       rs147444184       rs147830004       rs147980395       rs147986331       rs148017282       rs148121496       rs148456994       rs148630114       rs148768534       rs148786669       rs148872360       rs148925589       rs148981301       rs148993071       rs149045793       rs149155205       rs149261007       rs149264225       rs149316010       rs149437579       rs149519775       rs149673466       rs149702440       rs149798087       rs149908022       rs150077237       rs150129017       rs150267584       rs150320888       rs150600851       rs150851901       rs150968755       rs150988781       rs151061340       rs151216179       rs151281368       rs180776352       rs180790537       rs180897793       rs180916961       rs180928266       rs181427131       rs181544792       rs181564363       rs181652113       rs181661649       rs182067650       rs182145604       rs182156263       rs182330978       rs182414650       rs182575269       rs182752207       rs182768378       rs182895382       rs182908714       rs183113349       rs183453539       rs183454862       rs183536970       rs183966912       rs184205866       rs184346980       rs184397491       rs184516732       rs184882339       rs184892920       rs184925803       rs185013122       rs185030029       rs185046787       rs185047751       rs185092587       rs185517959       rs185612717       rs185640983       rs185754556       rs185763130       rs185781400       rs185913022       rs186310483       rs186341297       rs186456628       rs186544522       rs186583525       rs186825935       rs186948111       rs186960024       rs187176627       rs187277973       rs187520110       rs187616012       rs187684985       rs187767587       rs187896522       rs187897518       rs187982646       rs188034413       rs188057665       rs188201710       rs188343949       rs188355556       rs188404021       rs188547530       rs188703950       rs189136749       rs189175118       rs189290571       rs189329074       rs189370194       rs189406285       rs189609373       rs189817013       rs189874529       rs190048743       rs190136933       rs190184939       rs190254456       rs190598327       rs190626266       rs190642490       rs190650732       rs190773101       rs190783700       rs191002116       rs191061882       rs191161133       rs191422512       rs191487212       rs191524521       rs191549566       rs191567735       rs191721767       rs191787959       rs191824278       rs192002688       rs192093653       rs192376535       rs192381016       rs192537705       rs192639396       rs192825592       rs192858052       rs193069514       rs193168499       rs199550708       rs199586229       rs199812847       rs199921289       rs200119903       rs200144942       rs200203203       rs200239046       rs200316045       rs200372830       rs200528455       rs200727893       rs200787297       rs200914624       rs201406536       rs201671612       rs201984032       rs202246105       rs367705048       rs367777871       rs367890878       rs368164162       rs368232244       rs368338923       rs368340141       rs368500294       rs368527287       rs368628123       rs368637616       rs369222896       rs369340382       rs369363384       rs369544681       rs369634962       rs369726925       rs369765128       rs369781461       rs369916626       rs369921459       rs370231567       rs370231602       rs370343478       rs370378188       rs370579436       rs370831106       rs370951694       rs370984008       rs371008569       rs371126337       rs371131254       rs371457884       rs371544938       rs371550914       rs371742245       rs372054040       rs372091658       rs372283699       rs372369027       rs372591012       rs372611156       rs372693830       rs372879493       rs372977800       rs373213679       rs373498059       rs373524727       rs373824947       rs373855786       rs373938787       rs374170222       rs374241194       rs374643027       rs374709046       rs374991437       rs375381622       rs375500679       rs375600890       rs375726390       rs375910885       rs376098931       rs376138614       rs376501688       rs376638019       rs376689505       rs376703451       rs376959049       rs377025537       rs377606044       rs377655559       rs377709390       rs527248016       rs527313471       rs527314652       rs527372859       rs527373586       rs527434404       rs527510158       rs527576579       rs527634110       rs527787671       rs527845427       rs527911024       rs527922211       rs528235329       rs528295682       rs528501149       rs528554494       rs529037984       rs529074054       rs529133913       rs529205816       rs529267740       rs529521832       rs529612802       rs529780217       rs530212344       rs530336279       rs530429606       rs530895491       rs530952287       rs531074874       rs531136673       rs531354163       rs531357872       rs531416855       rs531459723       rs531540837       rs531703151       rs531836794       rs531895339       rs531926651       rs531953948       rs531963704       rs532157026       rs532221340       rs532348959       rs532487167       rs532654098       rs532690352       rs532755069       rs532991049       rs533043169       rs533045311       rs533058603       rs533738325       rs533750138       rs533894793       rs533912653       rs533942283       rs533965126       rs534094887       rs534158729       rs534238431       rs534359029       rs534417173       rs534428381       rs534535915       rs534603455       rs534670133       rs534913875       rs535113956       rs535174150       rs535276380       rs535647902       rs535656209       rs536143101       rs536210960       rs536401963       rs536417329       rs536484613       rs536545266       rs536731342       rs536758217       rs537289173       rs537342328       rs537393745       rs537402751       rs537456154       rs537744058       rs537799435       rs537947148       rs537951196       rs538125090       rs538127762       rs538870437       rs538873992       rs538935326       rs538935400       rs539210070       rs539412764       rs539487162       rs539671459       rs539817669       rs540051695       rs540099992       rs540125977       rs540205552       rs540252196       rs540324662       rs540528710       rs540603568       rs540772515       rs540900580       rs541064301       rs541125396       rs541396158       rs541457809       rs541519152       rs541613978       rs541616612       rs541618521       rs541654171       rs541686692       rs541750655       rs541900491       rs542365700       rs542383879       rs542445243       rs542490766       rs542652331       rs542745367       rs542751353       rs542874309       rs543028948       rs543193014       rs543445342       rs543708668       rs543759736       rs543940066       rs543971634       rs544126030       rs544174819       rs544188719       rs544235422       rs544505181       rs544518543       rs544917447       rs545100486       rs545142792       rs545204320       rs545204389       rs545250816       rs545265667       rs545292952       rs545311526       rs545311712       rs545357561       rs545494291       rs545700638       rs545710947       rs545768238       rs545915303       rs545982703       rs545988655       rs546155317       rs546310365       rs546342967       rs546371933       rs546373692       rs546384583       rs546433325       rs546546997       rs546939081       rs546953043       rs547119159       rs547644815       rs547706472       rs547878124       rs547893884       rs548133754       rs548423926       rs548458216       rs548589169       rs548663775       rs548814484       rs548943430       rs548986424       rs549047850       rs549133149       rs549212232       rs549277263       rs549298449       rs549417672       rs549478722       rs550072003       rs550085104       rs550187348       rs550262661       rs550337750       rs550357357       rs550727346       rs550812685       rs551272257       rs551481803       rs551551650       rs551613146       rs551947265       rs552580251       rs552610392       rs553236952       rs553294152       rs553531313       rs553717033       rs553853555       rs554003639       rs554003885       rs554066427       rs554127860       rs554395941       rs554679964       rs554916152       rs554926548       rs554935853       rs554989449       rs554989688       rs555053773       rs555339946       rs555403318       rs555476137       rs555731520       rs556173636       rs556193238       rs556254794       rs556276373       rs556337794       rs556397653       rs556451922       rs556591351       rs556673662       rs556725006       rs556776193       rs556905829       rs556967125       rs557449284       rs557450092       rs557640250       rs557701917       rs557789973       rs557990346       rs558258979       rs558571664       rs558635592       rs559145813       rs559190435       rs559253620       rs559420498       rs559858297       rs560263913       rs560284095       rs560292219       rs560531646       rs560683827       rs560723678       rs560934635       rs560993523       rs561053378       rs561117925       rs561274586       rs561329624       rs561414277       rs561671977       rs561673882       rs561735237       rs561799505       rs561921319       rs562065667       rs562213162       rs562422353       rs562442430       rs562473417       rs562614263       rs562679669       rs562770801       rs562935396       rs563196566       rs563478472       rs563535577       rs563801731       rs563863888       rs563863960       rs564072081       rs564318768       rs564504825       rs565004247       rs565255732       rs565412268       rs565751057       rs566017949       rs566077674       rs566081095       rs566479745       rs566535225       rs566546411       rs566733422       rs566797259       rs566870458       rs567033555       rs567087935       rs567129053       rs567273633       rs567276838       rs567334736       rs567462043       rs567524535       rs567524670       rs567584736       rs567605316       rs567789625       rs567897470       rs568092733       rs568101529       rs568350753       rs568369956       rs568519882       rs568635626       rs568644600       rs568657437       rs568780174       rs568811632       rs569053840       rs569480572       rs569977384       rs570070238       rs570134944       rs570298478       rs570324134       rs570767214       rs570851102       rs570916487       rs571209914       rs571258009       rs571319875       rs571562351       rs571565906       rs571676114       rs571746332       rs571807555       rs572156156       rs572222663       rs572282806       rs572284608       rs572348620       rs572477665       rs572825327       rs572916470       rs572979041       rs573019517       rs573294675       rs573325917       rs573559611       rs573714613       rs573777323       rs573870978       rs573905992       rs573994901       rs574049355       rs574112429       rs574232721       rs574427524       rs574585611       rs574692997       rs574868603       rs574890354       rs574961013       rs574964767       rs575040368       rs575104316       rs575118326       rs575166591       rs575414612       rs575488756       rs575676523       rs575694372       rs575758090       rs575950709       rs575968673       rs576301900       rs576391937       rs576410393       rs576451646       rs576656382       rs577379584       rs577452612       rs577466509       rs577597291       rs577687831       rs577846077       rs745371333       rs745581812       rs745669893       rs745870273       rs745876002       rs746155042       rs746225488       rs746239862       rs746417812       rs746461721       rs746510715       rs746525323       rs746540613       rs746724078       rs746728770       rs746815680       rs746833836       rs746834690       rs746922487       rs747078637       rs747082474       rs747276515       rs747385356       rs747521044       rs747865466       rs747891102       rs748115703       rs748140665       rs748354829       rs748407632       rs748483914       rs748564572       rs748734710       rs748773096       rs748779976       rs748808029       rs748914270       rs749002569       rs749189062       rs749256535       rs749406224       rs749519115       rs749691043       rs749887981       rs749940749       rs749954630       rs750004607       rs750232343       rs750246770       rs750413045       rs750495638       rs750501622       rs750626193       rs750742558       rs750762527       rs750892904       rs750980669       rs751029245       rs751113447       rs751309783       rs751350770       rs751451090       rs751545075       rs751645746       rs751650268       rs751874039       rs752097911       rs752143932       rs752144613       rs752251596       rs752442084       rs752478685       rs752724316       rs752774607       rs752808682       rs752809928       rs753054514       rs753248745       rs753369575       rs753377828       rs753384739       rs753489834       rs753560845       rs753881199       rs753962365       rs754163124       rs754197621       rs754559037       rs754747895       rs754773960       rs754875188       rs754877406       rs754966175       rs754999159       rs755229178       rs755329548       rs755453060       rs755470661       rs755485446       rs755614612       rs755797035       rs755885544       rs756104137       rs756304376       rs756307761       rs756351130       rs756399381       rs756669130       rs756705717       rs756843900       rs756938509       rs756964309       rs757344745       rs757482301       rs757523393       rs757593762       rs757648121       rs757687296       rs757844231       rs757886137       rs757983865       rs758063228       rs758084490       rs758301500       rs758303478       rs758391984       rs758420067       rs758424852       rs758565275       rs758796306       rs758807446       rs758828714       rs758961744       rs759272381       rs759445381       rs759608189       rs759655523       rs759731962       rs760030045       rs760162365       rs760181903       rs760301696       rs760460780       rs760508275       rs760734929       rs760797760       rs760883267       rs760990411       rs761171625       rs761228283       rs761434194       rs761439756       rs761883704       rs762006556       rs762028401       rs762109636       rs762184285       rs762332953       rs762362326       rs762567513       rs762672434       rs762692979       rs762831120       rs762938990       rs763058510       rs763067089       rs763323426       rs763490500       rs763650093       rs763745606       rs763748898       rs763840735       rs763862185       rs763867953       rs764118096       rs764311440       rs764344270       rs764434165       rs764453292       rs764491038       rs764617582       rs764870240       rs764980978       rs765457750       rs765637165       rs765739252       rs765851143       rs766001275       rs766080596       rs766199914       rs766200168       rs766249286       rs766322893       rs766517242       rs766563497       rs766703556       rs766781718       rs766872340       rs766909063       rs767172065       rs767296856       rs767345417       rs767469858       rs767557176       rs767964059       rs768141767       rs768224336       rs768485897       rs768723254       rs768864995       rs768881445       rs769302628       rs769338273       rs769602140       rs769855508       rs770050631       rs770362678       rs770363275       rs770553781       rs770574279       rs770574395       rs770768881       rs770793294       rs770797841       rs770963103       rs771092262       rs771149059       rs771155896       rs771215017       rs771550712       rs771567130       rs771682148       rs771706428       rs771729036       rs771746757       rs771876967       rs771950716       rs772287339       rs772629148       rs772654554       rs772706128       rs773158681       rs773350227       rs773351321       rs773416791       rs773436993       rs773539755       rs773634161       rs773683200       rs773998446       rs774124535       rs774141247       rs774145028       rs774145037       rs774385766       rs774392923       rs774545919       rs774955780       rs774957592       rs775118490       rs775151876       rs775208666       rs775321090       rs775651527       rs775709454       rs775716378       rs775829317       rs775845847       rs775847859       rs776067275       rs776073986       rs776268474       rs776294933       rs776299859       rs776343735       rs776592116       rs776668851       rs776674591       rs776957988       rs777026708       rs777114687       rs777231519       rs777319242       rs777352650       rs777528137       rs777600054       rs777684374       rs777787585       rs778056320       rs778075390       rs778196798       rs778262801       rs778339380       rs778368657       rs778458675       rs778497296       rs778599774       rs778651050       rs778780532       rs778812981       rs778933636       rs779110679       rs779125524       rs779224265       rs779400339       rs779436566       rs779436617       rs779487127       rs779489394       rs779506735       rs779594654       rs779694463       rs779797530       rs779958037       rs779965761       rs780025601       rs780074606       rs780085513       rs780179383       rs780211545       rs780324727       rs780451218       rs780547892       rs780730822       rs780922940       rs781049359       rs781187322       rs781203376       rs781307595       rs781314460       rs781432453       rs781472169       rs781568380       rs781675146      

TRIM3基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CAAGTTCAAGACCAAGATTGG
58
ACAATGATATGTCCATTCCGG
58
GTGTATTCAGTCTGCTACTAAGTC
59
CAAGGAAATTGGCTGGAGG
59
AACTTCTTCATCAGCAGCCT
60
AAACTCCATCGTCTTGCCT
59
TGCACACCTTCTGTGAGAG
60
CTGGACAGGATAGCGTCAG
60
CAACTTCTTCATCAGCAGCC
60
AAACTCCATCGTCTTGCCT
59
ACTTCTTCATCAGCAGCCT
59
AAACTCCATCGTCTTGCCT
59
GTATTCAGTCTGCTACTAAGTCTC
58
CCAAGGAAATTGGCTGGAG
59
CAGTGAAGGTGTACAGTGC
59
TTGGAGTCCACAGCTACTC
59
ACTTCTTCATCAGCAGCCT
59
AAACTCCATCGTCTTGCCT
59
CTCTTCAAGTTTGGCTCCC
59
CTGTCGAATACCTGGATGC
58
      尚未收录相关数据

TRIM3基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

TRIM3基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0005622
E9PMK8(UniProtKB)
IEA
GO:0008270
E9PMK8(UniProtKB)
IEA
GO:0008270
E9PMW5(UniProtKB)
IEA
GO:0005515
O75382(UniProtKB)
IPI
GO:0005737
O75382(UniProtKB)
TAS
GO:0005769
O75382(UniProtKB)
IEA
GO:0007399
O75382(UniProtKB)
TAS
GO:0008022
O75382(UniProtKB)
TAS
GO:0008270
O75382(UniProtKB)
IEA
GO:0015031
O75382(UniProtKB)
IEA
GO:0016567
O75382(UniProtKB)
IEA
GO:0061630
O75382(UniProtKB)
IEA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控TRIM3基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Schizophrenia 0.00272435 1 0 LHGDN
Glioblastoma 0.000542884 2 0 BeFree
Glioma 0.000542884 2 0 BeFree
Brain Neoplasms 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree
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