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The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
[中文简述(自动翻译):]  由该基因编码的蛋白质包含一个RING锌指,已知参与蛋白质 - 蛋白质相互作用的基序。这种蛋白质与雄激素受体(AR)进行交互,并且可以作为诱导前列腺AR靶基因表达的共活化剂的作用。此基因的显性失活突变体已被证明抑制前列腺癌的AR介导的生长。这种蛋白也与第三类泛素结合酶(E2S)相互作用,并且可以为在某些核蛋白质的泛素化一个泛素连接酶(E3)行动。六可变剪接转录物变体编码两种不同的同种型已被报道。 [由RefSeq的,2011年1月提供]
RNF14基因(以及对应的蛋白质)的细胞分布位置:
RNF14基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Amyotrophic Lateral Sclerosis | 0.002367032 | 1 | 3 | GAD |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Azoospermia | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Azoospermia, Nonobstructive | 0.000271442 | 1 | 0 | BeFree |
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