RNF14(ring finger protein 14)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

5q23.3-q31.1
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]

[中文简述(自动翻译):]  由该基因编码的蛋白质包含一个RING锌指，已知参与蛋白质 - 蛋白质相互作用的基序。这种蛋白质与雄激素受体（AR）进行交互，并且可以作为诱导前列腺AR靶基因表达的共活化剂的作用。此基因的显性失活突变体已被证明抑制前列腺癌的AR介导的生长。这种蛋白也与第三类泛素结合酶（E2S）相互作用，并且可以为在某些核蛋白质的泛素化一个泛素连接酶（E3）行动。六可变剪接转录物变体编码两种不同的同种型已被报道。 [由RefSeq的，2011年1月提供]

OMIM数据库中对RNF14基因的介绍     Wikipedia数据库中对RNF14基因的介绍

基因序列

基因序列

RNF14基因的碱基序列：[NCBI]

基因突变

基因突变

RNF14基因的碱基突变：           显示全部snp
rs3087       rs10873       rs164494       rs164495       rs164496       rs164516       rs187542       rs187543       rs187544       rs192243       rs194042       rs252089       rs252090       rs252095       rs252096       rs252097       rs252098       rs252099       rs252100       rs252101       rs252102       rs252103       rs252104       rs252130       rs252131       rs252132       rs252133       rs252134       rs252135       rs252136       rs252137       rs252138       rs252139       rs252140       rs252141       rs252142       rs364287      
rs374840       rs407749       rs411264       rs424485       rs429336       rs433623       rs434934       rs589674       rs740662       rs1638534       rs1650639       rs3804256       rs5871798       rs5871799       rs6876841       rs6881931       rs6883171       rs6887148       rs6896399       rs7702578       rs7702858       rs7702863       rs7703226       rs7704196       rs7707253       rs7707267       rs7711457       rs7719153       rs7723712       rs7723891       rs7724045       rs7725888       rs7728738       rs7734658       rs10036101       rs10073655       rs10476832       rs10476833       rs11167762       rs11385874       rs11741467       rs11746000       rs11951200       rs11951260       rs11955124       rs12055307       rs12109500       rs13185334       rs13361163       rs17097934       rs17097937       rs34068832       rs34181518       rs34631427       rs34675918       rs35006338       rs35025341       rs35087752       rs35097018       rs35103066       rs35167600       rs41290611       rs41290613       rs55650781       rs56229749       rs57620589       rs59211146       rs59850636       rs61748691       rs61748697       rs61750770       rs61753579       rs62380045       rs62380048       rs62380049       rs63697861       rs66768569       rs71576127       rs71590783       rs71590784       rs71592134       rs72035790       rs72303922       rs72796057       rs72796058       rs72796060       rs72796061       rs72796064       rs73276054       rs73276075       rs73792088       rs74678495       rs74704193       rs74709227       rs74777034       rs75142204       rs75242770       rs75251980       rs75554782       rs75696034       rs75746303       rs75774668       rs76031530       rs76320700       rs76844050       rs77078491       rs77300336       rs77871833       rs77873131       rs78313076       rs78411212       rs78500367       rs78645883       rs78683441       rs78829670       rs78904720       rs78921695       rs79025689       rs79049164       rs79182959       rs79197106       rs79271159       rs79676534       rs80103350       rs80310022       rs111570082       rs111574530       rs112321759       rs112408097       rs112451454       rs112460925       rs112772711       rs112817960       rs113301693       rs113421508       rs113514012       rs113539536       rs113563443       rs113778238       rs113899344       rs113919982       rs113992342       rs114037047       rs114098215       rs114260188       rs114338535       rs114354790       rs114402581       rs114452210       rs114484266       rs114835235       rs115034640       rs115088670       rs115520786       rs115709687       rs116160048       rs116209308       rs116276946       rs116322678       rs116346879       rs116351048       rs116580810       rs116589485       rs116642057       rs117013400       rs117828217       rs138098478       rs138138852       rs138158057       rs138199196       rs138351051       rs138453771       rs138952656       rs139122866       rs139298196       rs139407118       rs139478313       rs139793272       rs139883863       rs139991916       rs140290586       rs140426681       rs140533810       rs141060768       rs141325101       rs141423024       rs141489448       rs141694109       rs141717987       rs142035854       rs142321168       rs142365134       rs142377927       rs143042506       rs143068472       rs143126117       rs143248185       rs143406654       rs143635131       rs143920002       rs144068459       rs144179546       rs144312419       rs144357810       rs144498098       rs144749625       rs144786175       rs144898955       rs144980658       rs145595253       rs145645445       rs145714451       rs145747414       rs145818673       rs145910758       rs146256995       rs146599563       rs146606807       rs146950478       rs147059342       rs147402888       rs147661971       rs147682722       rs147841932       rs148567871       rs148683883       rs148694881       rs148732575       rs149008405       rs149057006       rs149282494       rs149370878       rs149426962       rs149688651       rs149828826       rs150190433       rs150237988       rs150500657       rs150509025       rs150560979       rs150568523       rs151294694       rs151303211       rs180884159       rs181106982       rs181354631       rs181789875       rs181884717       rs182044835       rs182053085       rs182089184       rs182295202       rs182580678       rs182588456       rs182890524       rs183191877       rs183197510       rs183399040       rs183614158       rs183702972       rs183907579       rs184217337       rs184300746       rs184303955       rs184525800       rs184744384       rs184747209       rs184887334       rs185005487       rs185147031       rs185245603       rs185283002       rs185489326       rs185557037       rs185792707       rs185803718       rs186292096       rs186303218       rs186395567       rs186508421       rs186580074       rs186717224       rs187031086       rs187241468       rs187454775       rs187523010       rs187553799       rs187574234       rs187781474       rs187793930       rs188058447       rs188285600       rs188310327       rs188318401       rs188559020       rs188609252       rs188811724       rs188836137       rs189054968       rs189241214       rs189354733       rs189444116       rs189484582       rs189588337       rs189610537       rs189725621       rs189888018       rs189954512       rs189968426       rs190127647       rs190363883       rs190380705       rs190387025       rs190876636       rs190928928       rs191092596       rs191100621       rs191162221       rs191655394       rs191753843       rs191953447       rs191959168       rs192256997       rs192402817       rs192451466       rs192662371       rs192879394       rs192963615       rs193020358       rs193067631       rs199517606       rs199776881       rs199833689       rs199953121       rs200081623       rs200103265       rs200479605       rs200639964       rs201158916       rs201188255       rs201236187       rs201336979       rs201361875       rs201399386       rs201469464       rs201489382       rs201856613       rs202044181       rs202148127       rs202193063       rs367880202       rs367987511       rs368004474       rs368041467       rs368646575       rs368905970       rs369026481       rs369199648       rs369259715       rs369401378       rs369487885       rs369660821       rs369750547       rs369778503       rs369968420       rs370144010       rs370235570       rs370451068       rs370877884       rs371145348       rs371326548       rs371380661       rs371705897       rs371885845       rs371996038       rs372232503       rs372319011       rs372835475       rs373147965       rs373618361       rs373659810       rs373761285       rs373990207       rs374848091       rs374887888       rs375230576       rs375234487       rs375343745       rs375496457       rs375617896       rs376049805       rs376088806       rs376173586       rs376623642       rs376841429       rs376845958       rs376859005       rs376977493       rs377192926       rs377452281       rs397817246       rs397999453       rs397999454       rs398038873       rs527242691       rs527308116       rs527360278       rs527364754       rs527442979       rs527663359       rs527839513       rs527962267       rs528023817       rs528425109       rs528506943       rs528662309       rs528934030       rs529054886       rs529268763       rs529457325       rs529587036       rs529678772       rs529803315       rs529978479       rs530066807       rs530132290       rs530195194       rs530197244       rs530291445       rs530593168       rs530970511       rs531018854       rs531282165       rs531705274       rs531847629       rs531886166       rs532167969       rs532200815       rs532289552       rs532319666       rs532549402       rs532709113       rs532712130       rs532941213       rs532953188       rs533099699       rs533252435       rs533321986       rs533449652       rs533743923       rs533887678       rs533926397       rs534118203       rs534145306       rs534576186       rs534829160       rs535036470       rs535119967       rs535213441       rs535623168       rs535829254       rs535877946       rs536009297       rs536073584       rs536127973       rs536406274       rs536594622       rs536855209       rs536998297       rs537127039       rs537183208       rs537190129       rs537190455       rs537400481       rs537805204       rs537988989       rs538009365       rs538009874       rs538072713       rs538239659       rs538453779       rs538581910       rs538785326       rs539779664       rs540038365       rs540172381       rs540248504       rs540621326       rs540756804       rs540800020       rs540855292       rs540977437       rs541018856       rs541153622       rs541441251       rs541525688       rs541653223       rs541750760       rs542011134       rs542130723       rs542198462       rs542431591       rs542456618       rs542660824       rs542861757       rs543035735       rs543047305       rs543175379       rs543175424       rs543402405       rs543405787       rs543661601       rs543790187       rs543797326       rs543825943       rs544133833       rs544527921       rs544729274       rs544772642       rs544838569       rs544864360       rs544927274       rs545083208       rs545110749       rs545383286       rs545405638       rs545449787       rs545481649       rs545900695       rs546102660       rs546213540       rs546671277       rs546806089       rs547307144       rs547408704       rs547491242       rs547573982       rs547589976       rs547797138       rs548358332       rs548533511       rs548661485       rs548684908       rs549032482       rs549192482       rs549405978       rs549406082       rs549623780       rs549778687       rs549810466       rs549917158       rs549930642       rs549935055       rs549956159       rs549970208       rs550080106       rs550358119       rs550370667       rs550477398       rs550611010       rs550809093       rs551091864       rs551547584       rs551919485       rs551943216       rs552022711       rs552201462       rs552304480       rs552315105       rs552469103       rs552527760       rs552593341       rs552740073       rs552801982       rs552908823       rs552973255       rs553321140       rs553355336       rs553372538       rs553511166       rs553581354       rs553645913       rs553666904       rs553774409       rs553991168       rs554052474       rs554301186       rs554347978       rs554512446       rs554525330       rs554588726       rs554926245       rs555015368       rs555398582       rs555521197       rs555626639       rs556065616       rs556475314       rs556659590       rs556745106       rs556776466       rs556923354       rs557455481       rs557593147       rs557658575       rs557732011       rs557735441       rs557995474       rs558025027       rs558250360       rs558345871       rs558428502       rs558439320       rs558475304       rs558505824       rs558715232       rs558765432       rs558966936       rs558974538       rs559127634       rs559177062       rs559238958       rs559262596       rs559381479       rs559763358       rs560263231       rs560338643       rs560341924       rs560731623       rs560987317       rs560992879       rs561180121       rs561204739       rs561268405       rs561338793       rs561394063       rs561531031       rs561582572       rs561609287       rs561691654       rs562042612       rs562863482       rs562959536       rs563050457       rs563335602       rs563614667       rs563662799       rs564283516       rs564338033       rs564346769       rs564523022       rs564584546       rs564647173       rs564719792       rs564990419       rs565112643       rs565118128       rs565173905       rs565250519       rs565454924       rs565865971       rs565922326       rs566160202       rs566187628       rs566451985       rs566786236       rs566975649       rs567024863       rs567167671       rs567177882       rs567553376       rs567565371       rs567576029       rs567855299       rs568037271       rs568137303       rs568227122       rs568289826       rs568333764       rs568472668       rs568626384       rs568873543       rs569311066       rs569400387       rs569522230       rs569585379       rs569680395       rs569779026       rs569867993       rs569889730       rs569926534       rs570204223       rs570219416       rs570283716       rs570323758       rs570627755       rs571049598       rs571069203       rs571252321       rs571293035       rs571351070       rs571434187       rs571438754       rs571558914       rs571925422       rs572109860       rs572456782       rs572787689       rs572848806       rs573286104       rs573303112       rs573467695       rs573588013       rs573805359       rs573853654       rs573917721       rs573939609       rs573995904       rs574314523       rs574466279       rs574477613       rs574543667       rs574572449       rs574621315       rs574780737       rs574921297       rs575450213       rs575496844       rs575883921       rs575934846       rs576021426       rs576212827       rs576351387       rs576439372       rs576602128       rs576709911       rs576827660       rs576864514       rs576922506       rs577335384       rs577457923       rs577473296       rs577854178       rs577866466       rs578176117       rs578258149       rs745772334       rs746025016       rs746144532       rs746233191       rs746252167       rs746533277       rs746943364       rs746993764       rs747011186       rs747261225       rs747422748       rs747659249       rs747785306       rs747984113       rs748139689       rs748239865       rs748557080       rs748753336       rs748754648       rs748926113       rs748935663       rs749010093       rs749863045       rs749980492       rs750074718       rs750076416       rs750192221       rs750911334       rs750947038       rs751093159       rs751223781       rs751306717       rs751313763       rs751385492       rs751475701       rs751696146       rs751781284       rs752521061       rs752611229       rs752623374       rs752749361       rs752750022       rs752856670       rs752948839       rs753111266       rs753386817       rs753546885       rs753690692       rs754145440       rs754453508       rs754740638       rs754752442       rs754840413       rs754931399       rs755271840       rs755291870       rs755539041       rs755593160       rs755710046       rs756071947       rs756106893       rs756470735       rs756676710       rs757299804       rs757469931       rs757786493       rs758052881       rs758142751       rs758144474       rs758207002       rs758294962       rs758386033       rs758487179       rs758499796       rs758800339       rs758895793       rs759073992       rs759685165       rs760013568       rs760172502       rs760283765       rs760371788       rs760377455       rs760539278       rs760685075       rs760826430       rs761303114       rs761399927       rs761611519       rs762141519       rs762148480       rs762537853       rs763023641       rs763123248       rs763213156       rs763386195       rs763474516       rs763475842       rs763956128       rs764020497       rs764334086       rs764396561       rs764486654       rs764875716       rs764972691       rs765377623       rs765959330       rs765963956       rs765971131       rs766052792       rs766432535       rs766810386       rs767213510       rs767253068       rs767343080       rs767430881       rs767660424       rs767735115       rs768143442       rs768180645       rs768208503       rs768298374       rs768316217       rs768599167       rs768845108       rs769070428       rs769147771       rs769221989       rs769360850       rs769376053       rs769463947       rs769680258       rs769741930       rs769769499       rs769930159       rs769972507       rs770172556       rs770279604       rs770525629       rs770907142       rs771146689       rs771394669       rs771401411       rs771553634       rs771593152       rs772233498       rs772624507       rs772714133       rs772850029       rs772889922       rs773300346       rs773303212       rs773495726       rs773568838       rs773678358       rs773944964       rs774605418       rs774711285       rs774739267       rs774887576       rs774958417       rs775057807       rs775211771       rs775270149       rs775390227       rs776055960       rs776257634       rs776493391       rs776793151       rs776920783       rs777300776       rs777392165       rs777699128       rs777764504       rs778418112       rs778522939       rs778626647       rs778906911       rs778922327       rs779016312       rs779355497       rs779446352       rs779502102       rs779546873       rs779752506       rs779865727       rs779951131       rs780038226       rs780416664       rs780513365       rs780612528       rs780638144       rs781066549       rs781118509       rs781535864       rs869309968      

基因表达

基因表达

RNF14基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GAGATGGAAAGTAAGGAGTGG
57
TCCGTCTAATTTCTCTATGGGA
58
CCAGATTATCCATCCTCTTCC
57
GCATAGAGCAGATAGCTGAG
58
CCAGATCAGAGATGGCCAG
60
CTCTTTGACCTGACCAGGAG
60
TGCCACCAGATTATCCATCC
60
GAGCAGATAGCTGAGTTGGT
60
AGAGTCTGTCCAAGGTGGA
59
TCATTTGAATTGCCGCTCAC
59
CAGATCAGAGATGGCCAGG
60
ACTCTTTGACCTGACCAGG
59
ATGAACTCCACTCTGAGCTG
59
TCTGACGACATAAGGACCTG
59
TGTCCAAGGTGGAGAAACC
60
CACTCATTTGAATTGCCGCT
60
GAGTCTGTCCAAGGTGGAG
59
CCACTAACTCTTTGACCGC
59
GAGTCTGTCCAAGGTGGAG
59
CACTAACTCTTTGACCGCTC
59

转录因子

转录因子

转录因子
影响类型
PubMed链接
CCND1
Activation
17510080

基因本体信息

RNF14基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

RNF14基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004842
D6R988(UniProtKB)
IEA
GO:0016567
D6R988(UniProtKB)
IEA
GO:0004842
D6R996(UniProtKB)
IEA
GO:0016567
D6R996(UniProtKB)
IEA
GO:0004842
D6RA38(UniProtKB)
IEA
GO:0008270
D6RA38(UniProtKB)
IEA
GO:0016567
D6RA38(UniProtKB)
IEA
GO:0004842
D6RAS4(UniProtKB)
IEA
GO:0016567
D6RAS4(UniProtKB)
IEA
GO:0004842
D6RBK4(UniProtKB)
IEA
GO:0016567
D6RBK4(UniProtKB)
IEA
GO:0004842
D6RBU3(UniProtKB)
IEA
GO:0016567
D6RBU3(UniProtKB)
IEA
GO:0004842
D6RDU6(UniProtKB)
IEA
GO:0016567
D6RDU6(UniProtKB)
IEA
GO:0004842
E7EP22(UniProtKB)
IEA
GO:0016567
E7EP22(UniProtKB)
IEA
GO:0046872
E7EP22(UniProtKB)
IEA
GO:0000151
Q9UBS8(UniProtKB)
IBA
GO:0000209
Q9UBS8(UniProtKB)
IBA
GO:0003713
Q9UBS8(UniProtKB)
TAS
GO:0003713
Q9UBS8(UniProtKB)
NAS
GO:0005515
Q9UBS8(UniProtKB)
IPI
GO:0005515
Q9UBS8(UniProtKB)
IPI
GO:0005515
Q9UBS8(UniProtKB)
IPI
GO:0005515
Q9UBS8(UniProtKB)
IPI
GO:0005515
Q9UBS8(UniProtKB)
IPI
GO:0005515
Q9UBS8(UniProtKB)
IPI
GO:0005515
Q9UBS8(UniProtKB)
IPI
GO:0005634
Q9UBS8(UniProtKB)
IDA
GO:0005737
Q9UBS8(UniProtKB)
IDA
GO:0005737
Q9UBS8(UniProtKB)
IDA
GO:0006351
Q9UBS8(UniProtKB)
IEA
GO:0006355
Q9UBS8(UniProtKB)
IDA
GO:0006357
Q9UBS8(UniProtKB)
TAS
GO:0007165
Q9UBS8(UniProtKB)
TAS
GO:0008270
Q9UBS8(UniProtKB)
IEA
GO:0016567
Q9UBS8(UniProtKB)
IEP
GO:0016874
Q9UBS8(UniProtKB)
IEA
GO:0019787
Q9UBS8(UniProtKB)
IDA
GO:0030521
Q9UBS8(UniProtKB)
NAS
GO:0030521
Q9UBS8(UniProtKB)
NAS
GO:0031624
Q9UBS8(UniProtKB)
IBA
GO:0032436
Q9UBS8(UniProtKB)
IBA
GO:0042787
Q9UBS8(UniProtKB)
IBA
GO:0045893
Q9UBS8(UniProtKB)
NAS
GO:0045893
Q9UBS8(UniProtKB)
IDA
GO:0050681
Q9UBS8(UniProtKB)
IPI
GO:0060765
Q9UBS8(UniProtKB)
IDA
GO:0061630
Q9UBS8(UniProtKB)
IBA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控RNF14基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Prostatic Neoplasms 0.00272435 1 0 LHGDN
Amyotrophic Lateral Sclerosis 0.002367032 1 3 GAD
Malignant neoplasm of prostate 0.000542884 2 0 BeFree
Prostate carcinoma 0.000542884 2 0 BeFree
Azoospermia 0.000271442 1 0 BeFree
Malignant tumor of colon 0.000271442 1 0 BeFree
Colon Carcinoma 0.000271442 1 0 BeFree
Azoospermia, Nonobstructive 0.000271442 1 0 BeFree

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