RNASE1(ribonuclease, RNase A family, 1 (pancreatic))

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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14q11.2
基因染色体位置图

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  该基因编码的胰型分泌核糖核酸酶时,核糖核酸酶A家族的子集的成员。上的嘧啶碱基的3‘侧的编码核酸内切酶切割的内部磷酸二酯的RNA键。它更聚(C)作为底物和水解2‘,3‘-环状核苷酸,具有最佳pH附近8.0。所编码的蛋白质是单体和更常见的作用超过β-RNA的降解的ds-RNA。选择性剪接发生在该位点和编码相同蛋白4转录变体也已确定。 [由RefSeq的,2008年7月提供]

RNASE1基因的碱基序列:[NCBI]
RNASE1基因的碱基突变:           显示全部snp
rs13487       rs1804215       rs2273708       rs4982365       rs4982366       rs10145281       rs10145636       rs11545378       rs11545379       rs12883202       rs17254352       rs17523303       rs28378018       rs45626434       rs56017873       rs61978587       rs73582001       rs73582002       rs74034609       rs74034610       rs74034612       rs78426213       rs111816905       rs111837579       rs113971533       rs137913839       rs137934838       rs139476638       rs141923373       rs142277981       rs142457376       rs143064811       rs143351335       rs143436195       rs144718326       rs145424082       rs146297570      
rs148221178       rs149988557       rs150479420       rs150678259       rs150792279       rs180793253       rs181082069       rs182175480       rs182470815       rs183776899       rs185425950       rs185811398       rs186998059       rs187108787       rs187185349       rs187844125       rs188121065       rs188191605       rs188731647       rs189555544       rs189847094       rs191439869       rs191598889       rs192851325       rs192941525       rs193264848       rs200900834       rs201527730       rs367591111       rs367926098       rs368804528       rs369310116       rs370681451       rs370813266       rs370850841       rs371385743       rs372510186       rs372724258       rs374108453       rs374528089       rs375322502       rs376304915       rs377292546       rs527787691       rs528112767       rs528192128       rs530290915       rs530634928       rs531982300       rs533020007       rs534764629       rs537028797       rs537093467       rs537163428       rs537758828       rs539177281       rs540997009       rs542831307       rs543464596       rs544937766       rs545345818       rs545347418       rs546240449       rs546360927       rs546569644       rs547807143       rs548731111       rs549066569       rs549691901       rs551222746       rs551552654       rs551622825       rs553146785       rs553343582       rs554083359       rs554185571       rs555113365       rs557269489       rs557807105       rs557931898       rs558364593       rs559582932       rs560946882       rs561009875       rs562939478       rs564580682       rs565610437       rs565759447       rs566350990       rs566534610       rs567290365       rs571110297       rs572034382       rs572578798       rs573671677       rs574076731       rs575208864       rs576067562       rs577463136       rs577925820       rs746090740       rs746951001       rs747037298       rs747043125       rs748095765       rs750082539       rs750170705       rs750187194       rs750818847       rs750981570       rs752193325       rs752642959       rs753421601       rs753591280       rs753753665       rs753839755       rs754970022       rs755163403       rs755284155       rs755961507       rs756965465       rs757016129       rs758044294       rs758592083       rs759121954       rs759954169       rs760230338       rs761244763       rs761675706       rs762105023       rs763061287       rs763580905       rs764060974       rs764959769       rs766003086       rs766939808       rs768823499       rs769240382       rs769597015       rs770122963       rs770257111       rs771064671       rs772113858       rs772171393       rs773471346       rs773558626       rs774345632       rs774447700       rs774975700       rs776036094       rs777081326       rs777163288       rs777556230       rs780118815       rs781060801       rs781775796      

RNASE1基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
AGATCCAGGTCACTTTGTAGG
59
AAGAGACTTCTCCAGAGCC
58
AGAAACTGGCCTTCCATCTC
60
TTACAGTAGGTGGAGCTGC
59
AAGACCTCGCTTTGGAGAG
59
AAGAGACTTCTCCAGAGCC
58
AGATCCAGGTCACTTTGTAGG
59
CAAGAGACTTCTCCAGAGCC
60
AAGACCTCGCTTTGGAGAG
59
CAAGAGACTTCTCCAGAGCC
60
GAAACTGGCCTTCCATCTC
58
GTTACAGTAGGTGGAGCTG
57
AAGACCTCGCTTTGGAGAG
59
AGAGACTTCTCCAGAGCCA
60
AAGACCTCGCTTTGGAGAG
59
AAGAGACTTCTCCAGAGCC
58
AGAAACTGGCCTTCCATCTC
60
AGAGACTTCTCCAGAGCCA
60
AAGACCTCGCTTTGGAGAG
59
CAAGAGACTTCTCCAGAGCC
60
      尚未收录相关数据

RNASE1基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

RNASE1基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0003676
G3V357(UniProtKB)
IEA
GO:0004519
G3V357(UniProtKB)
IEA
GO:0090305
G3V357(UniProtKB)
IEA
GO:0090305
G3V357(UniProtKB)
IEA
GO:0003676
P07998(UniProtKB)
IEA
GO:0004522
P07998(UniProtKB)
IEA
GO:0005515
P07998(UniProtKB)
IPI
GO:0070062
P07998(UniProtKB)
IDA
GO:0070062
P07998(UniProtKB)
IDA
GO:0090502
P07998(UniProtKB)
IEA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控RNASE1基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Neoplasm Metastasis 0.0127677 37 0 BeFree_LHGDN
Malignant neoplasm of prostate 0.011368221 11 0 BeFree_GAD
Carcinogenesis 0.005700279 21 0 BeFree
Glioma 0.004885954 18 0 BeFree
Malignant neoplasm of breast 0.00434307 16 0 BeFree
Breast Carcinoma 0.00434307 16 0 BeFree
Colorectal Cancer 0.004267125 8 0 BeFree_GAD
melanoma 0.003257302 12 0 BeFree
Stomach Neoplasms 0.00272435 1 0 LHGDN
Glioblastoma 0.002714419 10 0 BeFree
Tumor Progression 0.002442977 9 0 BeFree
Pancreatic carcinoma 0.002442977 9 0 BeFree
Malignant neoplasm of pancreas 0.002442977 9 0 BeFree
Hereditary Nonpolyposis Colorectal Cancer 0.002367032 1 0 GAD
Non-Small Cell Lung Carcinoma 0.002171535 8 0 BeFree
Prostate carcinoma 0.002171535 8 0 BeFree
Malignant tumor of colon 0.001900093 7 0 BeFree
Colorectal Carcinoma 0.001900093 7 0 BeFree
Malignant neoplasm of stomach 0.001900093 7 0 BeFree
Stomach Carcinoma 0.001900093 7 0 BeFree
Malignant neoplasm of lung 0.001628651 6 0 BeFree
Carcinoma of lung 0.001628651 6 0 BeFree
Colon Carcinoma 0.001628651 6 0 BeFree
leukemia 0.001357209 5 0 BeFree
Pancreatic Neoplasm 0.001357209 5 0 BeFree
Liver carcinoma 0.001357209 5 0 BeFree
Colorectal Neoplasms 0.001085767 4 0 BeFree
Hypertensive disease 0.001085767 4 0 BeFree
Kidney Diseases 0.001085767 4 0 BeFree
Neurilemmoma 0.001085767 4 0 BeFree
Leukemogenesis 0.001085767 4 0 BeFree
Pancreatic Ductal Adenocarcinoma 0.001085767 4 0 BeFree
Brain Neoplasms 0.000814326 3 0 BeFree
Squamous cell carcinoma 0.000814326 3 0 BeFree
Dengue Fever 0.000814326 3 0 BeFree
HIV Infections 0.000814326 3 0 BeFree
Leukemia, Myelocytic, Acute 0.000814326 3 0 BeFree
Osteosarcoma 0.000814326 3 0 BeFree
Kaposi Sarcoma 0.000814326 3 0 BeFree
Deficiency of mevalonate kinase 0.000814326 3 0 BeFree
Osteosarcoma of bone 0.000814326 3 0 BeFree
Secondary malignant neoplasm of lymph node 0.000814326 3 0 BeFree
Sarcoma 0.000814326 3 1 BeFree
Mammary Neoplasms 0.000814326 3 0 BeFree
Tumor Angiogenesis 0.000814326 3 0 BeFree
Amyotrophic Lateral Sclerosis 0.000542884 2 0 BeFree
Astrocytoma 0.000542884 2 0 BeFree
Autistic Disorder 0.000542884 2 0 BeFree
Renal Cell Carcinoma 0.000542884 2 0 BeFree
Ulcerative Colitis 0.000542884 2 0 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.000542884 2 0 BeFree
Inflammatory Bowel Diseases 0.000542884 2 1 BeFree
Ischemia 0.000542884 2 0 BeFree
Lymphoma 0.000542884 2 0 BeFree
Medulloblastoma 0.000542884 2 0 BeFree
Mental Retardation 0.000542884 2 0 BeFree
Neuroblastoma 0.000542884 2 0 BeFree
Degenerative polyarthritis 0.000542884 2 0 BeFree
Cerebrovascular accident 0.000542884 2 0 BeFree
synovial sarcoma 0.000542884 2 0 BeFree
Adenocarcinoma of lung (disorder) 0.000542884 2 0 BeFree
Adenocarcinoma Of Esophagus 0.000542884 2 0 BeFree
Chronic Kidney Insufficiency 0.000542884 2 0 BeFree
Central neuroblastoma 0.000542884 2 0 BeFree
Chronic Kidney Diseases 0.000542884 2 0 BeFree
Triple Negative Breast Neoplasms 0.000542884 2 0 BeFree
Acute pancreatitis 0.000271442 1 0 BeFree
Alzheimer's Disease 0.000271442 1 0 BeFree
Anaplasia 0.000271442 1 0 BeFree
Aneurysm 0.000271442 1 0 BeFree
Arteriosclerosis Obliterans 0.000271442 1 0 BeFree
Asbestosis 0.000271442 1 0 BeFree
Malignant neoplasm of skin 0.000271442 1 0 BeFree
Noninfiltrating Intraductal Carcinoma 0.000271442 1 0 BeFree
Cerebral Infarction 0.000271442 1 0 BeFree
Malignant tumor of cervix 0.000271442 1 0 BeFree
Cherubism 0.000271442 1 0 BeFree
Colitis 0.000271442 1 0 BeFree
Colonic Neoplasms 0.000271442 1 0 BeFree
Crohn Disease 0.000271442 1 0 BeFree
Cyst 0.000271442 1 0 BeFree
Mental Depression 0.000271442 1 0 BeFree
Depressive disorder 0.000271442 1 0 BeFree
Dwarfism 0.000271442 1 0 BeFree
Shigella Infections 0.000271442 1 0 BeFree
Ectodermal Dysplasia 0.000271442 1 0 BeFree
Breast Fibrocystic Disease 0.000271442 1 0 BeFree
Giant Cell Tumors 0.000271442 1 0 BeFree
Focal glomerulosclerosis 0.000271442 1 0 BeFree
Influenza 0.000271442 1 0 BeFree
Menkes Kinky Hair Syndrome 0.000271442 1 0 BeFree
Lesch-Nyhan Syndrome 0.000271442 1 0 BeFree
Chronic Lymphocytic Leukemia 0.000271442 1 0 BeFree
Myeloid Leukemia 0.000271442 1 0 BeFree
Leukemia, T-Cell 0.000271442 1 0 BeFree
Liver diseases 0.000271442 1 0 BeFree
Myeloproliferative disease 0.000271442 1 0 BeFree
Neurofibromatosis 1 0.000271442 1 0 BeFree
Neurofibromatosis 2 0.000271442 1 0 BeFree
Osteogenesis Imperfecta 0.000271442 1 0 BeFree
Osteoporosis, Postmenopausal 0.000271442 1 0 BeFree
Papilloma 0.000271442 1 0 BeFree
Parathyroid Neoplasms 0.000271442 1 0 BeFree
Pulmonary Fibrosis 0.000271442 1 0 BeFree
Rhabdomyosarcoma 0.000271442 1 0 BeFree
Schizophrenia 0.000271442 1 0 BeFree
Sebaceous Gland Neoplasms 0.000271442 1 0 BeFree
Dermatologic disorders 0.000271442 1 0 BeFree
Skin Neoplasms 0.000271442 1 0 BeFree
Stress Disorders, Traumatic 0.000271442 1 0 BeFree
Syndactyly 0.000271442 1 0 BeFree
Pancreatitis, Chronic 0.000271442 1 0 BeFree
Cutaneous Melanoma 0.000271442 1 0 BeFree
Malignant neoplasm of mouth 0.000271442 1 0 BeFree
Neurofibromatoses 0.000271442 1 0 BeFree
Lip and Oral Cavity Carcinoma 0.000271442 1 0 BeFree
Adams Oliver syndrome 0.000271442 1 0 BeFree
Exudative age-related macular degeneration 0.000271442 1 0 BeFree
Impaired glucose tolerance 0.000271442 1 0 BeFree
Myomatous neoplasm 0.000271442 1 0 BeFree
Cervix carcinoma 0.000271442 1 0 BeFree
Adenocarcinoma of colon 0.000271442 1 0 BeFree
Impaired cognition 0.000271442 1 0 BeFree
Hypocalciuric hypercalcemia, familial, type 1 0.000271442 1 0 BeFree
Neurodegenerative Disorders 0.000271442 1 0 BeFree
Ewings sarcoma 0.000271442 1 0 BeFree
Malignant Glioma 0.000271442 1 0 BeFree
Chemical Carcinogenesis 0.000271442 1 0 BeFree
Tumor Initiation 0.000271442 1 0 BeFree
Helicobacter pylori infection 0.000271442 1 0 BeFree
Invasive breast carcinoma 0.000271442 1 0 BeFree
Rhabdoid Tumor of the Kidney 0.000271442 1 0 BeFree
Cerebral Ischemia 0.000271442 1 0 BeFree
ovarian neoplasm 0.000271442 1 0 BeFree
Infantile malignant osteopetrosis 0.000271442 1 0 BeFree
Sebaceous adenoma 0.000271442 1 0 BeFree
Neuropathogenesis 0.000271442 1 0 BeFree
Skin Carcinogenesis 0.000271442 1 0 BeFree
Xenograft Model 0.000271442 1 0 BeFree
cancer angiogenesis 0.000271442 1 0 BeFree
Limb ischemia 0.000271442 1 0 BeFree
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