RLN2(relaxin 2)

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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9p24.1
基因染色体位置图

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]

[中文简述(自动翻译):]  松弛素是已知的内分泌和自分泌/旁分泌激素,属于胰岛素基因超家族。在人类有三种非等位基因的松弛素基因,RLN1,RLN2和RLN3,其中RLN1和RLN2分享高序列同源性。由该基因编码的蛋白质的活性形式是由一个A链和由二硫键连接的B链。松弛素是由卵巢产生,并且针对哺乳动物生殖系统成熟宫颈,拉长耻骨联合,抑制子宫收缩。它可能有增强精子活力,调节血压,控制心脏率和释放催产素和血管加压素其他角色。这个基因的选择性剪接的结果在多个转录变体。 [由RefSeq的,2013年1月提供]

RLN2基因的碱基序列:[NCBI]
RLN2基因的碱基突变:           显示全部snp
rs471037       rs471068       rs533649       rs999060       rs1322220       rs1407386       rs1407387       rs1407388       rs1575277       rs1853218       rs1853219       rs1853220       rs1885495       rs1885496       rs1885497       rs1885498       rs2025169       rs2146074       rs2146075       rs2181145       rs2273782       rs2273784       rs2890629       rs3758240       rs4119229       rs4278200       rs4740810       rs4742078       rs4742079       rs4742080       rs4742081       rs6476961       rs6476962       rs7021193       rs7022239       rs7027672       rs7031719      
rs7034440       rs7035195       rs7035226       rs7039729       rs7044690       rs7047608       rs7469056       rs7848509       rs7849015       rs7857208       rs7858028       rs7858347       rs7861799       rs7863534       rs7871658       rs9695268       rs10116687       rs10117651       rs10125965       rs10435742       rs10491649       rs10758680       rs10815179       rs10815180       rs10815181       rs10975050       rs10975051       rs10975052       rs10975053       rs10975056       rs11551507       rs11793069       rs11794994       rs12056968       rs12338169       rs12344125       rs12350801       rs12379219       rs12551269       rs12554802       rs12686525       rs13297190       rs28446653       rs28698164       rs28713722       rs28731244       rs28850909       rs34612061       rs34807596       rs35088261       rs35316688       rs35426888       rs36123525       rs55930144       rs56059921       rs56235721       rs56996481       rs57244573       rs57702698       rs58504459       rs58618579       rs58968405       rs59441173       rs60035170       rs60299004       rs60509036       rs60735956       rs60970474       rs61236751       rs61401592       rs61706845       rs62557692       rs62638697       rs62638699       rs71326155       rs71487818       rs71498612       rs71498613       rs71501824       rs72499174       rs72499177       rs72703640       rs72703642       rs72703643       rs73393279       rs73393298       rs73639273       rs73639274       rs73639275       rs73639276       rs73639277       rs73639280       rs73639281       rs73639282       rs73639283       rs73639284       rs73639285       rs74700624       rs74788005       rs75312080       rs75456823       rs75679551       rs75823265       rs75825221       rs75843765       rs75885289       rs75888755       rs76094482       rs76236605       rs76430768       rs76636506       rs77128935       rs77263015       rs77377004       rs77511300       rs77544638       rs77590258       rs77631500       rs77737536       rs77987980       rs78233390       rs78256401       rs78360441       rs78866167       rs78902181       rs78954328       rs79084029       rs79422873       rs79560191       rs79783091       rs79946857       rs80035372       rs80096720       rs111280743       rs111285678       rs111749225       rs112318888       rs112362150       rs112434221       rs112482782       rs112737453       rs112884465       rs112891388       rs112894861       rs113097864       rs113156672       rs113192310       rs113324264       rs113462224       rs113482561       rs113553897       rs113623304       rs113678308       rs113723760       rs113837013       rs113870563       rs113940017       rs114011611       rs114056771       rs114287053       rs114294517       rs114443623       rs114559138       rs114560436       rs114682761       rs114816081       rs114950602       rs114953834       rs115194072       rs115197490       rs115362875       rs115386103       rs115443988       rs115468882       rs115473740       rs115599022       rs115660015       rs115663263       rs115835974       rs115868004       rs116012717       rs116283232       rs116497035       rs116551306       rs116933160       rs116994310       rs117088331       rs117191534       rs117367979       rs117586430       rs117898870       rs137858312       rs137992378       rs138002200       rs138051943       rs138075606       rs138117283       rs138320356       rs138324551       rs138380404       rs138563276       rs138614296       rs138680945       rs138711065       rs138715549       rs138733330       rs138930259       rs138938965       rs138999736       rs139130724       rs139197046       rs139294857       rs139341724       rs139484586       rs139517054       rs139584640       rs139617189       rs139674544       rs139697631       rs139762226       rs139830980       rs140073699       rs140220176       rs140350306       rs140417241       rs140467511       rs140570837       rs140610906       rs140680082       rs140721558       rs140777349       rs140954536       rs141018307       rs141056958       rs141101090       rs141122826       rs141177954       rs141422581       rs141474261       rs141794512       rs141938641       rs142061683       rs142076110       rs142124284       rs142125368       rs142193566       rs142238288       rs142264769       rs142414023       rs142504109       rs142508802       rs142539979       rs142610521       rs142687399       rs142721722       rs142870561       rs142936349       rs143025204       rs143165582       rs143203801       rs143341576       rs143468790       rs143582652       rs143583034       rs143649891       rs143727400       rs143938299       rs143984444       rs144018475       rs144048426       rs144118124       rs144197235       rs144241669       rs144272606       rs144374461       rs144536191       rs144679740       rs144749958       rs144771394       rs144813485       rs144826128       rs144879941       rs144937778       rs145070573       rs145158543       rs145525345       rs145548946       rs145563561       rs145609606       rs145771544       rs145786158       rs145822419       rs145835654       rs145837313       rs145863164       rs145897083       rs145911528       rs145942579       rs145943581       rs145961506       rs146225836       rs146306135       rs146344587       rs146362685       rs146365261       rs146476202       rs146513762       rs146549416       rs146649730       rs146688786       rs146770443       rs146930778       rs146947713       rs147296781       rs147319958       rs147336859       rs147424954       rs147441093       rs147545748       rs147602636       rs147633216       rs147706831       rs147723185       rs147810731       rs147827098       rs147963253       rs147986729       rs148148197       rs148181164       rs148291364       rs148339575       rs148394367       rs148583914       rs148603537       rs148655019       rs148724705       rs148777211       rs148903475       rs148923143       rs148936801       rs148974832       rs149042947       rs149069258       rs149253729       rs149275193       rs149435419       rs149524022       rs149545634       rs149627613       rs149643915       rs149681610       rs149752411       rs149803606       rs150015848       rs150140803       rs150260966       rs150279376       rs150402302       rs150420654       rs150492805       rs150581246       rs150600191       rs150668925       rs150720715       rs150880724       rs150939525       rs150988218       rs151041280       rs151201127       rs151321389       rs180681656       rs180687554       rs180693632       rs180921529       rs180948882       rs180955540       rs180955670       rs180990239       rs181138927       rs181144362       rs181233922       rs181245647       rs181262613       rs181483372       rs181604643       rs181615482       rs181772266       rs181870246       rs181883181       rs182038245       rs182065605       rs182078187       rs182231820       rs182572608       rs182601637       rs182637130       rs182687972       rs182703278       rs182895507       rs182920627       rs183061811       rs183066690       rs183173233       rs183194301       rs183216241       rs183420531       rs183762573       rs183765543       rs183814035       rs184055989       rs184237447       rs184287679       rs184349697       rs184351742       rs184355969       rs184643344       rs184731971       rs184788312       rs184815396       rs184819486       rs184845752       rs184876542       rs185337872       rs185342962       rs185579449       rs185585292       rs185594342       rs185690950       rs185705774       rs186039742       rs186047267       rs186185993       rs186329292       rs186330833       rs186337664       rs186491502       rs186497969       rs186615189       rs186624527       rs186716413       rs186729773       rs186956907       rs186985916       rs186989980       rs186993119       rs187025605       rs187233448       rs187289901       rs187359233       rs187497282       rs187546584       rs187547539       rs187553585       rs187587297       rs188069694       rs188189270       rs188234177       rs188327643       rs188345036       rs188433233       rs188445414       rs188470016       rs188556486       rs188585853       rs188586818       rs188589067       rs188590175       rs188848611       rs188854721       rs188868939       rs188897702       rs189089364       rs189096521       rs189097276       rs189335516       rs189363547       rs189375295       rs189378469       rs189397265       rs189599683       rs189607337       rs189616269       rs189633015       rs189654500       rs189840741       rs189850848       rs189914203       rs190115897       rs190123807       rs190415974       rs190425192       rs190499419       rs190533120       rs190641307       rs190659154       rs190667172       rs190909533       rs191041213       rs191043293       rs191081966       rs191141445       rs191201286       rs191258718       rs191466870       rs191740996       rs191753263       rs191755525       rs191780747       rs191922763       rs191925911       rs191977199       rs192007996       rs192262933       rs192270297       rs192302476       rs192433291       rs192470723       rs192484423       rs192490615       rs192549413       rs192690277       rs192770195       rs192839428       rs192908822       rs192940976       rs192955464       rs193083066       rs193184952       rs193245486       rs199960272       rs200040297       rs200265055       rs200348324       rs200387461       rs200563966       rs201089402       rs201515257       rs201582837       rs202023998       rs367700423       rs367855585       rs367864928       rs368103769       rs368542609       rs368595655       rs368864540       rs368925357       rs369236293       rs369448766       rs369532231       rs369616777       rs370096694       rs370632195       rs370893296       rs371042734       rs371390590       rs371394654       rs371537460       rs371742833       rs371777701       rs371851858       rs372307726       rs372453403       rs372854927       rs373488708       rs373523772       rs373546096       rs374757456       rs374788646       rs375316567       rs375438712       rs375448117       rs376025600       rs376129010       rs376227406       rs376306030       rs376479792       rs376818446       rs376970406       rs377003639       rs377207357       rs377448599       rs397780021       rs527269498       rs527287757       rs527408853       rs527508549       rs527515088       rs527724003       rs527748990       rs527880260       rs527886237       rs528041729       rs528272096       rs528358076       rs528699288       rs528731235       rs528921395       rs528922462       rs528937266       rs529056867       rs529071509       rs529309580       rs529393710       rs529443397       rs529717368       rs529843249       rs529866248       rs529961793       rs529978116       rs530028191       rs530085970       rs530104802       rs530156876       rs530190916       rs530309217       rs530412021       rs530457232       rs530484046       rs530540062       rs530542348       rs530601212       rs531069442       rs531251731       rs531260591       rs531280674       rs531281057       rs531414266       rs531830174       rs531978431       rs532157384       rs532249071       rs532281368       rs532325544       rs532327179       rs532405955       rs532456463       rs532472887       rs532567169       rs532596953       rs532610892       rs532751045       rs532753893       rs532804479       rs532830529       rs532988064       rs533140665       rs533188567       rs533342234       rs533364667       rs533379138       rs533399439       rs533558947       rs533745276       rs533872410       rs533919282       rs533940204       rs534006649       rs534276308       rs534330912       rs534458238       rs534523295       rs534577967       rs535011640       rs535147867       rs535165561       rs535245082       rs535394956       rs535475651       rs535498890       rs535613401       rs535629922       rs535713839       rs535795836       rs535860191       rs535872555       rs536111317       rs536291242       rs536382736       rs536400631       rs536408328       rs536439836       rs536456335       rs536466294       rs536468286       rs536694378       rs536794520       rs536843323       rs536893322       rs536922440       rs536980957       rs537058472       rs537571333       rs537600861       rs537642681       rs537661804       rs537804618       rs537888452       rs537994338       rs538267889       rs538375475       rs538641318       rs538771545       rs538796049       rs538857122       rs539038263       rs539048377       rs539068891       rs539105419       rs539113209       rs539222794       rs539319698       rs539460195       rs539664548       rs539921338       rs540197804       rs540221740       rs540417859       rs540424275       rs540653470       rs540812610       rs540827121       rs540893586       rs541160110       rs541196207       rs541253000       rs541365972       rs541447336       rs541484464       rs541545533       rs541647318       rs541773959       rs541784890       rs541840638       rs541959223       rs542137747       rs542206009       rs542375660       rs542384378       rs542470267       rs542595186       rs542620162       rs542733985       rs542800263       rs542919114       rs542968434       rs542978034       rs542982212       rs543093073       rs543107355       rs543245167       rs543361461       rs543987486       rs544162994       rs544238093       rs544383593       rs544416862       rs544616457       rs544741094       rs544832882       rs544895670       rs544974609       rs545306204       rs545351439       rs545368290       rs545414446       rs545539267       rs545669606       rs545808300       rs545926122       rs546017362       rs546041009       rs546047076       rs546227760       rs546340504       rs546401861       rs546474864       rs546568551       rs546609892       rs546678355       rs546726187       rs546781031       rs546830581       rs546851341       rs546972779       rs547116265       rs547121542       rs547165034       rs547301940       rs547423325       rs547579589       rs547590735       rs547691000       rs548088747       rs548109524       rs548253536       rs548352401       rs548435266       rs548476055       rs548519802       rs548619556       rs548782903       rs548859665       rs549051615       rs549274807       rs549360699       rs549360956       rs549463385       rs549532597       rs549723573       rs549823996       rs549885766       rs549974639       rs549976729       rs550058886       rs550274087       rs550429311       rs550564052       rs550699538       rs550701379       rs550728559       rs550776985       rs550929464       rs551089779       rs551095408       rs551096437       rs551185017       rs551369872       rs551408180       rs551511675       rs552002880       rs552030403       rs552086414       rs552139844       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rs551403686       rs551692856       rs552158784       rs552258413       rs552551266       rs552616487       rs552744812       rs552754563       rs552757001       rs552774634       rs553359379       rs553797460       rs553880203       rs553942408       rs554471527       rs554721340       rs554879748       rs554959082       rs555284365       rs555289000       rs555680741       rs555821182       rs556146657       rs556282582       rs556407666       rs556766556       rs556878027       rs557458604       rs557592619       rs557794338       rs557920897       rs557931791       rs557931834       rs558202105       rs558406754       rs558982366       rs558994650       rs559113196       rs559336665       rs560222680       rs560347864       rs560507055       rs561257088       rs561292693       rs561450698       rs561485792       rs561688551       rs561878300       rs561938900       rs562374418       rs562893032       rs562962532       rs563041934       rs563236580       rs563279854       rs563364699       rs563651531       rs563679769       rs564087328       rs564206624       rs564256953       rs564261699       rs564327834       rs564330540       rs564466229       rs564501843       rs564553049       rs565029902       rs565439564       rs565493357       rs565501904       rs565637850       rs565811565       rs565909309       rs566758660       rs566811918       rs566820069       rs567006243       rs567010725       rs567069724       rs567206859       rs567707764       rs567907243       rs567942933       rs568004020       rs568121057       rs568199096       rs568258228       rs568380625       rs568842879       rs568926542       rs569429501       rs569480113       rs569496760       rs569517129       rs569526033       rs569600465       rs569797856       rs570120405       rs570229528       rs570721070       rs570806534       rs570808469       rs571230809       rs571384753       rs571818918       rs572008425       rs572045204       rs572095678       rs572174750       rs572182193       rs572416746       rs572416749       rs572425153       rs572540621       rs572686706       rs573151092       rs573247107       rs573474267       rs573599638       rs573657976       rs573950444       rs574229761       rs574318310       rs574457117       rs574723991       rs574919840       rs575086417       rs575203908       rs575388244       rs575430104       rs575477264       rs576082315       rs576217309       rs576666468       rs576682838       rs577113390       rs577257692       rs577281779       rs577396355       rs577505268       rs745448792       rs745998970       rs746309152       rs746620695       rs746642171       rs746901938       rs747155891       rs747647822       rs748073881       rs748116970       rs748273043       rs748407297       rs748424352       rs748592690       rs749699250       rs749765669       rs750001288       rs750028492       rs750619608       rs751101255       rs751612206       rs751737945       rs751907055       rs752221766       rs753212261       rs753409368       rs753451533       rs753538709       rs753738791       rs753957891       rs754013740       rs754253517       rs754376856       rs754625197       rs754652320       rs755758577       rs755812035       rs756101916       rs756152729       rs756314574       rs756413634       rs756769619       rs756928500       rs757229002       rs757438384       rs757477789       rs757561439       rs758618117       rs758718906       rs759445607       rs759872269       rs760294559       rs760922825       rs761538149       rs761574405       rs761856707       rs762305781       rs762330270       rs762352063       rs762829707       rs763001937       rs763218675       rs763441288       rs763488223       rs763646794       rs763802231       rs763901974       rs764193468       rs764248476       rs764578089       rs764960761       rs765197196       rs765355864       rs765416589       rs765476670       rs765646040       rs766003686       rs766015077       rs766410053       rs766461444       rs766776671       rs767020387       rs767650831       rs767845659       rs767976697       rs768091578       rs768518356       rs768622268       rs768808759       rs768910313       rs769103675       rs769156597       rs770198432       rs770782030       rs770928034       rs771614904       rs771949229       rs772597224       rs772867962       rs773024569       rs774064815       rs774193407       rs774486256       rs774654646       rs774880093       rs774899036       rs775260569       rs775348957       rs775637597       rs775685333       rs775944139       rs776086782       rs776596951       rs777062001       rs777425271       rs777626243       rs778023272       rs778025907       rs778322125       rs778467619       rs778493478       rs779392128       rs779694844       rs780030103       rs780405221       rs781109425       rs781337871       rs781352294       rs781541477       rs869311393      

RLN2基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图

RLN2基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

RLN2基因的本位(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0005179
P04090(UniProtKB)
IEA
GO:0005576
P04090(UniProtKB)
TAS
GO:0005576
P04090(UniProtKB)
TAS
GO:0005576
P04090(UniProtKB)
TAS
GO:0005576
P04090(UniProtKB)
TAS
GO:0005576
P04090(UniProtKB)
TAS
GO:0007565
P04090(UniProtKB)
TAS
GO:0010628
P04090(UniProtKB)
IDA
GO:0030819
P04090(UniProtKB)
IDA
GO:0045766
P04090(UniProtKB)
IMP
GO:0050790
P04090(UniProtKB)
IDA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控RLN2基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Prostatic Neoplasms 0.1254487 3 0 CTD_human_LHGDN
Thyroid Neoplasm 0.0054487 2 0 LHGDN
Hyperplasia 0.00272435 1 0 LHGDN
Myocardial Infarction 0.00272435 1 0 LHGDN
Premature Birth 0.002367032 1 0 GAD
Fibrinogen Adverse Event 0.002367032 1 1 GAD
Thyroid carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of breast 0.000271442 1 0 BeFree
Malignant neoplasm of thyroid 0.000271442 1 0 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
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