RIPK3(receptor-interacting serine-threonine kinase 3)

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

14q12
基因染色体位置图

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  这个基因的产物是受体相互作用蛋白(RIP)丝氨酸/苏氨酸蛋白激酶家族的一个成员,并含有来自其他RIP的家庭成员的独特的C-末端结构域。所编码的蛋白质主要是定位在细胞质中,并且可以进行核质穿梭依赖新颖核定位和出口信号。它是肿瘤坏死因子(TNF)受体 - 我信号复合的成分,并能诱导细胞凋亡和弱激活的NF-κB的转录因子。 [由RefSeq的,2008年7月提供]

RIPK3基因的碱基序列:[NCBI]
RIPK3基因的碱基突变:           显示全部snp
rs724165       rs2295299       rs2295300       rs2295301       rs3181251       rs3212254       rs10146747       rs12436194       rs57912421       rs61581888       rs61590472       rs76489333       rs79633122       rs112728788       rs113310572       rs115621096       rs139713262       rs141814546       rs142032353       rs142822920       rs143794271       rs145385449       rs148163991       rs148539168       rs150617061       rs181350139       rs183032643       rs186136975       rs186368014       rs188891298       rs191118658       rs199753664       rs200066851       rs200695583       rs200871983       rs201484127       rs201783081      
rs368692184       rs368978414       rs370193546       rs372756437       rs373318282       rs374877952       rs375655665       rs376263456       rs529736614       rs531261730       rs531266348       rs531994642       rs536252759       rs538636215       rs539161794       rs540566112       rs545445426       rs545910313       rs555919720       rs559033267       rs561542065       rs561583389       rs561589629       rs566894504       rs568219424       rs568747607       rs573149517       rs575139660       rs575805004       rs745350711       rs745938025       rs746428747       rs747070103       rs747312436       rs747485207       rs748449238       rs748839941       rs749116578       rs749133917       rs749527261       rs750042176       rs751049154       rs751559074       rs752066090       rs752152656       rs752403731       rs753218577       rs753273610       rs753498805       rs754012831       rs754017796       rs754196590       rs754250147       rs754964760       rs755596139       rs755894900       rs756554806       rs756673587       rs756762219       rs757285415       rs757466026       rs757671501       rs757875418       rs758615995       rs758992333       rs759152751       rs759209004       rs759209340       rs760593681       rs760600886       rs761292076       rs761300931       rs761669760       rs761892313       rs762069903       rs762553741       rs762654833       rs762968419       rs763932125       rs764430817       rs764492107       rs764636947       rs764846516       rs764969245       rs765240168       rs765471127       rs765873342       rs766033414       rs766444982       rs766795821       rs767072012       rs767413620       rs768545967       rs768917127       rs770238511       rs770595250       rs770775618       rs770926474       rs771176236       rs772929870       rs773057124       rs773422314       rs773479546       rs773546245       rs773830051       rs774060354       rs774472853       rs775962685       rs775963920       rs776458804       rs776622130       rs777800479       rs778175709       rs778896157       rs779218703       rs779561052       rs780150675       rs780445449       rs781771064       rs1007380       rs1007381       rs1950501       rs3181247       rs3181248       rs3212240       rs3212241       rs3212242       rs3212243       rs3212244       rs3212245       rs3212246       rs3212247       rs3212249       rs3212250       rs3212251       rs3212252       rs3212253       rs3759625       rs3759630       rs3834521       rs7153640       rs8008406       rs11844732       rs12588469       rs17184696       rs28379107       rs28620990       rs34106261       rs45453899       rs45537534       rs55924006       rs56330242       rs56337365       rs71405843       rs73591475       rs73591479       rs73591480       rs79855438       rs112137343       rs112973480       rs113160438       rs114213493       rs114413869       rs114872465       rs114970740       rs115212551       rs115520064       rs138819637       rs138908360       rs139771138       rs139820893       rs140844433       rs140945510       rs141301753       rs141928243       rs141948629       rs142489519       rs143073502       rs143896248       rs144028442       rs144222550       rs144353332       rs144418394       rs144963535       rs145474519       rs146116131       rs146455083       rs146886719       rs146983806       rs147837354       rs148033048       rs148293187       rs148690006       rs148851616       rs149213413       rs149904646       rs150086354       rs150214941       rs150669845       rs151192268       rs181124061       rs182119692       rs183066662       rs183353066       rs184653551       rs184799686       rs185155903       rs187444862       rs188388321       rs189136059       rs190004092       rs190355713       rs190925372       rs192533020       rs192704815       rs199559453       rs199742695       rs199909081       rs200086607       rs200182449       rs200189045       rs200189783       rs200284903       rs200520478       rs200590498       rs200951047       rs201028717       rs201121076       rs201438667       rs201591157       rs201663347       rs201783081       rs201887901       rs202022589       rs202233825       rs367685902       rs368257721       rs368772928       rs369010763       rs369109083       rs369249891       rs369407236       rs369619556       rs369895890       rs369990803       rs370199297       rs371715531       rs371790419       rs372302629       rs372495373       rs372641645       rs372654613       rs373231172       rs373410782       rs373767311       rs373809787       rs373898638       rs374696778       rs374850490       rs374950692       rs376305929       rs376764824       rs376832201       rs376863318       rs377051629       rs377344246       rs377606564       rs527672048       rs529642337       rs529845583       rs531752047       rs532183016       rs533207522       rs533365475       rs534453010       rs534913951       rs535090622       rs536227311       rs536421008       rs537050557       rs537244431       rs539240040       rs539787075       rs540263470       rs542280266       rs544919174       rs547625454       rs548168793       rs548560925       rs549923193       rs550556133       rs551555916       rs552069845       rs552705604       rs553168518       rs553451606       rs554724781       rs554943438       rs555789243       rs556980760       rs559243257       rs559304314       rs559958154       rs561426769       rs561985243       rs562212805       rs562904093       rs563388904       rs563544738       rs564252081       rs564416138       rs564905825       rs565552464       rs566328336       rs566694307       rs567541930       rs567677302       rs568424822       rs568665584       rs568769975       rs569271035       rs570018290       rs570627168       rs571024283       rs571257852       rs571997175       rs572227719       rs572372708       rs573339311       rs573932693       rs574388893       rs574778116       rs575625538       rs575662398       rs575901032       rs745404554       rs745456372       rs745578908       rs745580534       rs745631927       rs745789520       rs746079331       rs746239239       rs746432372       rs746521654       rs746576472       rs746604423       rs746865024       rs746888867       rs747014964       rs747146375       rs747171900       rs747302549       rs747302685       rs747354146       rs747504188       rs747557164       rs747996310       rs748087016       rs748219287       rs748258701       rs748288724       rs748324721       rs748451526       rs748515940       rs748640778       rs748933892       rs748986863       rs749012241       rs749120868       rs749184319       rs749231873       rs749400287       rs749689403       rs749741023       rs749748664       rs749862807       rs749917612       rs750038339       rs750112505       rs750219401       rs750342286       rs750344295       rs750449381       rs750603077       rs750638219       rs750669564       rs750757582       rs750949099       rs751093144       rs751152921       rs751237551       rs751290838       rs751345484       rs751474150       rs751571187       rs751797267       rs751994174       rs752045216       rs752047201       rs752271011       rs752277743       rs752352655       rs752461948       rs752620749       rs752642695       rs752685601       rs752747751       rs752977919       rs753087053       rs753240854       rs753342911       rs753370728       rs753443712       rs753498898       rs753766711       rs753874743       rs753880129       rs753939778       rs754119477       rs754238023       rs754374988       rs754445636       rs754459098       rs754556991       rs754629356       rs754841087       rs755039497       rs755256913       rs755408854       rs755535374       rs755583216       rs755631900       rs755638286       rs755763092       rs755905890       rs756084761       rs756134603       rs756255621       rs756273172       rs756388466       rs756618890       rs756762291       rs757073868       rs757219715       rs757266139       rs757340329       rs757344697       rs757463085       rs757492722       rs757907850       rs758039479       rs758161949       rs758486259       rs758675456       rs758877093       rs758937355       rs758969147       rs759157445       rs759276091       rs759543243       rs759666186       rs759689551       rs759787343       rs759953883       rs759957092       rs760172312       rs760312244       rs760490173       rs760867248       rs760938505       rs761055055       rs761071452       rs761101910       rs761359980       rs761384731       rs761410881       rs761512630       rs761718122       rs761808877       rs761887925       rs762016289       rs762020954       rs762072030       rs762167400       rs762195451       rs762329814       rs762503112       rs762530127       rs762555999       rs762606455       rs762812681       rs762935119       rs763023647       rs763158128       rs763231510       rs763340366       rs763556285       rs763808561       rs763832685       rs763972836       rs764154171       rs764304131       rs764327679       rs764335328       rs764388448       rs764448929       rs764583913       rs764596351       rs764665306       rs764718796       rs764919774       rs765286280       rs765466321       rs765467644       rs765518475       rs765701392       rs765807482       rs765929505       rs766088490       rs766139777       rs766251660       rs766467297       rs766522399       rs766666759       rs766899922       rs767007978       rs767022992       rs767061370       rs767185881       rs767581143       rs767706104       rs767757637       rs768143666       rs768165733       rs768271350       rs768494548       rs768553280       rs768554860       rs768788636       rs768968523       rs769019402       rs769077420       rs769130485       rs769354294       rs769409655       rs769413436       rs769689175       rs769694275       rs769825688       rs769847566       rs770121160       rs770265565       rs770580064       rs770628943       rs770812957       rs770873022       rs770953030       rs771204796       rs771261780       rs771264079       rs771344977       rs771400018       rs771548227       rs771638456       rs771816523       rs771826933       rs772028370       rs772225210       rs772347838       rs772437548       rs772474795       rs772528064       rs772818469       rs772958233       rs772983205       rs773036268       rs773361926       rs773481350       rs773536541       rs773661034       rs773716485       rs773957885       rs774277116       rs774356217       rs774453431       rs774596662       rs774671387       rs774825616       rs774854960       rs775053634       rs775177041       rs775238290       rs775353337       rs775406379       rs775576751       rs775677593       rs775727820       rs775989790       rs776028309       rs776055655       rs776075051       rs776110365       rs776405582       rs776458938       rs776772061       rs776898359       rs776944621       rs777127329       rs777309093       rs777568739       rs777702898       rs777875133       rs778090953       rs778260214       rs778424966       rs778438540       rs778834179       rs779011941       rs779295780       rs779327255       rs779417637       rs779602695       rs779612513       rs779661943       rs779937200       rs779973589       rs779985400       rs780322549       rs780430251       rs780451764       rs780553140       rs780677054       rs780805507       rs781008551       rs781073641       rs781160593       rs781220787       rs781222310       rs781571121       rs781628404       rs781672878       rs781680919      

RIPK3基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GTAAACTCGTGAGTGACCC
58
TTGACCTCCCTGGATATCG
58
GAAGTTGAGTTGCCAACCG
60
CTTCTAAGCCGGGAGTCTC
59
GGAACTGGAGAACCAGGAG
59
ATCGCCTTCGAGTTTACGA
59
ACTGGAACACCAAGTCCTG
60
GACCAGTTCATGCCTTGTC
59
GTCACTCCATCTCCTACGG
59
CTCCAGTTCCTCGATGGAC
60
GTCGTGCGTCAAGTTATGG
59
ATATCGCCTTCGAGTTTACGA
59
GTCGTGCGTCAAGTTATGG
59
ATCGCCTTCGAGTTTACGA
59
GTCGTGCGTCAAGTTATGG
59
TTCTCCAGTTCCTCGATGG
58
GTCGTGCGTCAAGTTATGG
59
TATCGCCTTCGAGTTTACGA
59
GTAAACTCGAAGGCGATATCC
59
CAGTTCACCTTCTCGATAACC
59
      尚未收录相关数据

RIPK3基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

RIPK3基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0001914
Q9Y572(UniProtKB)
ISS
GO:0002819
Q9Y572(UniProtKB)
ISS
GO:0003713
Q9Y572(UniProtKB)
TAS
GO:0004672
Q9Y572(UniProtKB)
IDA
GO:0004672
Q9Y572(UniProtKB)
IMP
GO:0004672
Q9Y572(UniProtKB)
IMP
GO:0004674
Q9Y572(UniProtKB)
ISS
GO:0004674
Q9Y572(UniProtKB)
TAS
GO:0004704
Q9Y572(UniProtKB)
IEA
GO:0005515
Q9Y572(UniProtKB)
IPI
GO:0005515
Q9Y572(UniProtKB)
IPI
GO:0005515
Q9Y572(UniProtKB)
IPI
GO:0005515
Q9Y572(UniProtKB)
IPI
GO:0005515
Q9Y572(UniProtKB)
IPI
GO:0005515
Q9Y572(UniProtKB)
IPI
GO:0005515
Q9Y572(UniProtKB)
IPI
GO:0005515
Q9Y572(UniProtKB)
IPI
GO:0005515
Q9Y572(UniProtKB)
IPI
GO:0005515
Q9Y572(UniProtKB)
IPI
GO:0005515
Q9Y572(UniProtKB)
IPI
GO:0005515
Q9Y572(UniProtKB)
IPI
GO:0005524
Q9Y572(UniProtKB)
IEA
GO:0005739
Q9Y572(UniProtKB)
IEA
GO:0005829
Q9Y572(UniProtKB)
IDA
GO:0005829
Q9Y572(UniProtKB)
TAS
GO:0005829
Q9Y572(UniProtKB)
TAS
GO:0005829
Q9Y572(UniProtKB)
TAS
GO:0005829
Q9Y572(UniProtKB)
TAS
GO:0005829
Q9Y572(UniProtKB)
TAS
GO:0005829
Q9Y572(UniProtKB)
TAS
GO:0005829
Q9Y572(UniProtKB)
TAS
GO:0005829
Q9Y572(UniProtKB)
TAS
GO:0005829
Q9Y572(UniProtKB)
TAS
GO:0005829
Q9Y572(UniProtKB)
TAS
GO:0005886
Q9Y572(UniProtKB)
IEA
GO:0006464
Q9Y572(UniProtKB)
TAS
GO:0007165
Q9Y572(UniProtKB)
TAS
GO:0007249
Q9Y572(UniProtKB)
IEA
GO:0010922
Q9Y572(UniProtKB)
IMP
GO:0032147
Q9Y572(UniProtKB)
IMP
GO:0032403
Q9Y572(UniProtKB)
IMP
GO:0032649
Q9Y572(UniProtKB)
ISS
GO:0033077
Q9Y572(UniProtKB)
ISS
GO:0038061
Q9Y572(UniProtKB)
IEA
GO:0042802
Q9Y572(UniProtKB)
IPI
GO:0043029
Q9Y572(UniProtKB)
ISS
GO:0046006
Q9Y572(UniProtKB)
ISS
GO:0046777
Q9Y572(UniProtKB)
IDA
GO:0048535
Q9Y572(UniProtKB)
ISS
GO:0048536
Q9Y572(UniProtKB)
ISS
GO:0048538
Q9Y572(UniProtKB)
ISS
GO:0051092
Q9Y572(UniProtKB)
IDA
GO:0051260
Q9Y572(UniProtKB)
IDA
GO:0051291
Q9Y572(UniProtKB)
IMP
GO:0051351
Q9Y572(UniProtKB)
IEA
GO:0051353
Q9Y572(UniProtKB)
IEA
GO:0060545
Q9Y572(UniProtKB)
IDA
GO:0060545
Q9Y572(UniProtKB)
IMP
GO:0070235
Q9Y572(UniProtKB)
ISS
GO:0070266
Q9Y572(UniProtKB)
IMP
GO:0070266
Q9Y572(UniProtKB)
IMP
GO:0070266
Q9Y572(UniProtKB)
TAS
GO:0070266
Q9Y572(UniProtKB)
TAS
GO:0090312
Q9Y572(UniProtKB)
IEA
GO:0097190
Q9Y572(UniProtKB)
TAS
GO:0097342
Q9Y572(UniProtKB)
IEA
GO:1990000
Q9Y572(UniProtKB)
IMP
GO:2000379
Q9Y572(UniProtKB)
IEA
GO:2000452
Q9Y572(UniProtKB)
ISS
GO:2001244
Q9Y572(UniProtKB)
IEA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控RIPK3基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Calcinosis 0.12 1 0 CTD_human
Heart valve disease 0.12 1 0 CTD_human
Lung Neoplasms 0.00272435 1 0 LHGDN
Inflammation 0.002367032 1 0 GAD
Lymphoma, Non-Hodgkin 0.002367032 1 0 GAD
HIV Infections 0.000542884 2 0 BeFree
Acute pancreatitis 0.000271442 1 0 BeFree
Adenocarcinoma 0.000271442 1 0 BeFree
Aneurysm 0.000271442 1 0 BeFree
Aortic Aneurysm 0.000271442 1 0 BeFree
Arteriosclerosis 0.000271442 1 0 BeFree
Atherosclerosis 0.000271442 1 0 BeFree
Malignant neoplasm of breast 0.000271442 1 0 BeFree
Malignant tumor of colon 0.000271442 1 0 BeFree
Malignant tumor of cervix 0.000271442 1 0 BeFree
Crohn Disease 0.000271442 1 0 BeFree
Esophageal Neoplasms 0.000271442 1 0 BeFree
Gaucher Disease 0.000271442 1 0 BeFree
Glioblastoma 0.000271442 1 0 BeFree
Hepatitis 0.000271442 1 0 BeFree
Hepatitis A 0.000271442 1 0 BeFree
Inflammatory Bowel Diseases 0.000271442 1 0 BeFree
Influenza 0.000271442 1 0 BeFree
leukemia 0.000271442 1 0 BeFree
Chronic Lymphocytic Leukemia 0.000271442 1 0 BeFree
Leukemia, Myelocytic, Acute 0.000271442 1 0 BeFree
Myeloid Leukemia 0.000271442 1 0 BeFree
Alcoholic Liver Diseases 0.000271442 1 0 BeFree
Multiple Sclerosis 0.000271442 1 0 BeFree
Myocardial Infarction 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Retinal Degeneration 0.000271442 1 0 BeFree
Small cell carcinoma of lung 0.000271442 1 0 BeFree
Esophageal carcinoma 0.000271442 1 0 BeFree
Systemic Inflammatory Response Syndrome 0.000271442 1 0 BeFree
Carcinoma, Small Cell 0.000271442 1 0 BeFree
Cervical Squamous Cell Carcinoma 0.000271442 1 0 BeFree
Cervix carcinoma 0.000271442 1 0 BeFree
Malignant neoplasm of esophagus 0.000271442 1 0 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
Colon Carcinoma 0.000271442 1 0 BeFree
Malignant neoplasm of ovary 0.000271442 1 0 BeFree
Allergic colitis 0.000271442 1 0 BeFree
Inflammatory disorder 0.000271442 1 0 BeFree
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