RGS4(regulator of G-protein signaling 4)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

1q23.3
基因染色体位置图

基因简述

基因简述

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  G蛋白信号传导的调节器（RGS）家族成员是充当异的G蛋白G的阿尔法亚基GTP酶激活蛋白（GAP）调节分子。 RGS蛋白能够停用在Gi的αG蛋白亚基，转到α和Gq蛋白的α亚型。他们驾驶的G蛋白进入它们的无效GDP结合的形式。 G蛋白信号4的稳压器属于这个家庭。所有RGS蛋白共享一个保守的120个氨基酸的序列被称为RGS域。 G蛋白信号4蛋白的调节剂是37％相同RGS1和97％相??同的大鼠RGS4。这种蛋白负调控上游或在异源G蛋白的水平信令和在细胞质中被定位。另外剪接转录变体也发现了这种基因。 [由RefSeq的，2008年7月提供]

OMIM数据库中对RGS4基因的介绍     Wikipedia数据库中对RGS4基因的介绍

基因序列

基因序列

RGS4基因的碱基序列：[NCBI]

基因突变

基因突变

RGS4基因的碱基突变：           显示全部snp
rs10759       rs14665       rs2344671       rs2661317       rs2661318       rs2661319       rs2661328       rs2842029       rs2842030       rs4307541       rs5778312       rs6678136       rs7515900       rs10799897       rs10917671       rs10917672       rs11544156       rs12041948       rs12043369       rs12067012       rs12087556       rs12402634       rs12720479       rs12753561       rs16848886       rs16848915       rs16848990       rs16864782       rs17441031       rs17493943       rs36214554       rs41271997       rs61812781       rs61812782       rs67187358       rs71641981       rs72703004      
rs75439269       rs75646098       rs75708071       rs75931331       rs75965774       rs76093732       rs76702833       rs76738003       rs77614426       rs78249897       rs79013223       rs80245863       rs111231749       rs112110969       rs112534087       rs112689842       rs113379670       rs113999620       rs114508725       rs114678896       rs114709373       rs115230970       rs115354513       rs115799602       rs115995541       rs116835163       rs116893819       rs117599588       rs137968433       rs137999044       rs138120044       rs138152202       rs138668396       rs138692900       rs139309610       rs139643075       rs139674129       rs140183962       rs140586628       rs141030182       rs141127469       rs141720318       rs141758274       rs142050556       rs142250495       rs142611213       rs142649160       rs142822667       rs143062615       rs143458568       rs144076476       rs144587531       rs144847321       rs145241035       rs145492172       rs145993018       rs146344978       rs146574298       rs146957659       rs147600228       rs147724223       rs147943921       rs148200026       rs148354656       rs148717745       rs149857366       rs150115659       rs150379217       rs150507916       rs151032270       rs180726075       rs181490889       rs181932602       rs182037632       rs182156398       rs182328631       rs182518015       rs182898282       rs182944549       rs183388559       rs183701887       rs183819159       rs184113892       rs185378743       rs185538945       rs185788393       rs186171883       rs186689062       rs186717643       rs186905716       rs187057457       rs187317857       rs187744943       rs188272599       rs188303462       rs188589529       rs189078099       rs189137066       rs189174832       rs189573100       rs189659109       rs190302513       rs190607247       rs190668999       rs191566465       rs191596255       rs192261269       rs192397396       rs192808031       rs193119079       rs193204003       rs199666067       rs199931864       rs200292394       rs200417634       rs200700353       rs201067248       rs201250643       rs201452079       rs201651024       rs201759642       rs201846465       rs367751756       rs368678746       rs368832504       rs368964432       rs369577878       rs370032435       rs370780643       rs371163312       rs372178408       rs372256208       rs372433068       rs373276299       rs373961033       rs373996473       rs374759383       rs374939117       rs376014169       rs376285994       rs376893352       rs377326798       rs397733390       rs397830819       rs527508801       rs527594673       rs527732983       rs527739177       rs527792035       rs527801132       rs528143841       rs528202564       rs528506738       rs528698342       rs528936510       rs528968052       rs529144539       rs529291409       rs529683512       rs529868086       rs530262276       rs530283692       rs530508619       rs531077977       rs531446715       rs531669710       rs531729918       rs531808462       rs531976526       rs532308706       rs532643509       rs532768379       rs533026035       rs533159072       rs533412286       rs533604670       rs535285475       rs536142989       rs536145869       rs536332298       rs536370983       rs536414451       rs536456225       rs536575288       rs537678917       rs537707024       rs538515904       rs538697364       rs538770603       rs538866982       rs538946301       rs539451000       rs539878649       rs540976550       rs541370202       rs542378827       rs542542015       rs542720632       rs542880361       rs542918806       rs542943698       rs543356163       rs543557790       rs543601215       rs543693631       rs543760572       rs543827602       rs544633658       rs544909170       rs544955787       rs545034642       rs546569364       rs546680370       rs546793260       rs546899431       rs547157993       rs547783661       rs547921613       rs548576886       rs548737419       rs548972447       rs549109372       rs549682890       rs550287011       rs551706816       rs551924860       rs552044984       rs552167058       rs552383978       rs552463973       rs552485631       rs552672788       rs552860141       rs553080074       rs553096657       rs553160924       rs553496109       rs553586174       rs554108526       rs554271778       rs554493457       rs554640921       rs555900481       rs555955376       rs556143061       rs557058359       rs557144393       rs557218166       rs557318495       rs558286390       rs558420174       rs558469791       rs558666224       rs558865730       rs559225771       rs559282897       rs559521802       rs560443320       rs560504364       rs560572186       rs561286971       rs561434525       rs562043537       rs562195742       rs562205789       rs562288249       rs562929595       rs563222613       rs563457804       rs563557589       rs563661821       rs563703118       rs564271461       rs564295863       rs564314514       rs564345254       rs564633820       rs564712215       rs564886796       rs564919202       rs564993710       rs565673234       rs566450311       rs566715006       rs566719290       rs566726988       rs567500067       rs567509526       rs567536966       rs567844489       rs567908824       rs567957674       rs568460365       rs568472007       rs568483336       rs568489938       rs568575440       rs568688370       rs568956380       rs569168107       rs569249131       rs569289531       rs569343044       rs569666199       rs570491218       rs571810082       rs572256922       rs572655254       rs572967257       rs573030126       rs573192496       rs573753134       rs573913330       rs574129156       rs574158979       rs574764346       rs574884759       rs574923299       rs575405955       rs575559935       rs576780525       rs577355257       rs577442739       rs577757761       rs577813161       rs745436300       rs746023897       rs746114391       rs746291994       rs746584678       rs747166576       rs747454979       rs747728482       rs748233197       rs748240377       rs748624719       rs748729021       rs748897715       rs749175484       rs749467145       rs749598523       rs749684718       rs749766819       rs749929250       rs750197911       rs750574493       rs750696818       rs750847357       rs751052850       rs751078752       rs751330431       rs751649661       rs751918019       rs751977075       rs752168365       rs752248754       rs752461966       rs752549666       rs753123481       rs753359722       rs753489638       rs753591502       rs753605991       rs753939198       rs754066876       rs754187105       rs754211047       rs754264498       rs754580032       rs754712769       rs754715985       rs754912049       rs755344846       rs755719218       rs755990605       rs756393648       rs756413720       rs756637182       rs756866312       rs757028476       rs757259527       rs757463473       rs757573706       rs757593860       rs757766146       rs757771553       rs757932227       rs758107976       rs758263807       rs758812138       rs759019522       rs759161436       rs759172375       rs759318283       rs759459890       rs759654367       rs759906948       rs760116562       rs760144424       rs760398732       rs760561420       rs760811280       rs761164403       rs761350506       rs761746821       rs761749898       rs761873439       rs762306735       rs762678103       rs763435868       rs763819180       rs763883610       rs763907200       rs764391130       rs764480988       rs764916965       rs765020745       rs765164767       rs765523075       rs765560010       rs766011285       rs766103822       rs766198964       rs766846585       rs766936548       rs767080587       rs767424762       rs767512758       rs767710713       rs768131750       rs768355409       rs768614270       rs768772021       rs769645711       rs769710563       rs769737268       rs770152187       rs770426247       rs770517308       rs771008986       rs771715416       rs772278945       rs772295314       rs772430184       rs773326724       rs773433866       rs773449574       rs774105200       rs774278771       rs774297235       rs774412904       rs774613513       rs774667103       rs775055123       rs775535185       rs775714471       rs775715951       rs775731096       rs776113439       rs776115869       rs776310977       rs776381782       rs776582169       rs776864331       rs776879544       rs777130164       rs777138159       rs777140816       rs777526265       rs778183516       rs778187040       rs778379879       rs779034550       rs779072617       rs779192564       rs779284765       rs779699408       rs779741194       rs780171728       rs780279015       rs780337696       rs780427687       rs780594376       rs780781267       rs780991964       rs781317904       rs781633813       rs781776916      

基因表达

基因表达

RGS4基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CAACCAAAGAGGTGAACCTG
59
CAAAGCAGGTTATTGTAGGCTC
60
ACATCGGCTAGGTTTCCTG
60
TTCCTCTTGGCTCACTCTC
59
TAGTCATGAATGTGGGCTGG
60
CTGATCCAGAAGTCAATATTCTCC
59
ATATTGACTTCTGGATCAGCTG
58
ATCAATATTTGGCCTTGGGA
57
ACCAAAGAGGTGAACCTGG
60
ATCAAAGCAGGTTATTGTAGGC
59
TAAACTAAGTCCCAAGGCCA
59
CAAGAATCCAGGTTCACCTC
58
ACCAAAGAGGTGAACCTGG
60
ATCAAAGCAGGTTATTGTAGGC
59
TAAACTAAGTCCCAAGGCCA
59
CAAGAATCCAGGTTCACCTC
58
ATATTGACTTCTGGATCAGCTG
58
ATCAATATTTGGCCTTGGGAC
59
GAGAAAGTTATGCTCTGTGCA
59
GAATTGTGTTCACAGGAATCAG
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

RGS4基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

RGS4基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000188
P49798(UniProtKB)
TAS
GO:0001965
P49798(UniProtKB)
IEA
GO:0005096
P49798(UniProtKB)
IEA
GO:0005516
P49798(UniProtKB)
TAS
GO:0005634
P49798(UniProtKB)
IDA
GO:0005737
P49798(UniProtKB)
IDA
GO:0005829
P49798(UniProtKB)
IEA
GO:0005886
P49798(UniProtKB)
IBA
GO:0008277
P49798(UniProtKB)
TAS
GO:0043234
P49798(UniProtKB)
IEA
GO:0043547
P49798(UniProtKB)
IEA
GO:0045744
P49798(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控RGS4基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Schizophrenia 0.216710349 49 4 BeFree_CTD_human_GAD_LHGDN
Endometriosis 0.12 1 0 CTD_human
IGA Glomerulonephritis 0.12 1 0 CTD_human
Bipolar Disorder 0.008544182 5 0 BeFree_GAD_LHGDN
Major Depressive Disorder 0.002909916 2 0 BeFree_GAD
Alzheimer's Disease 0.00272435 1 0 LHGDN
Alcoholic Intoxication, Chronic 0.002638474 1 0 BeFree_GAD
Squamous cell carcinoma 0.002367032 1 0 GAD
Head and Neck Neoplasms 0.002367032 1 0 GAD
Hypertensive disease 0.002367032 1 0 GAD
Liver Cirrhosis, Alcoholic 0.002367032 1 0 GAD
Marijuana Abuse 0.002367032 1 0 GAD
Neoplasm Recurrence, Local 0.002367032 1 0 GAD
Psychoses, Substance-Induced 0.002367032 1 0 GAD
Schizoaffective Disorder 0.002367032 1 0 GAD
Neoplasms, Second Primary 0.002367032 1 0 GAD
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Neuroblastoma 0.000542884 2 0 BeFree
Unipolar Depression 0.000542884 2 0 BeFree
Carcinogenesis 0.000542884 2 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Central neuroblastoma 0.000542884 2 0 BeFree
Mental disorders 0.000271442 1 0 BeFree
Malignant neoplasm of urinary bladder 0.000271442 1 1 BeFree
Fragile X Syndrome 0.000271442 1 0 BeFree
Glioma 0.000271442 1 0 BeFree
Heart failure 0.000271442 1 0 BeFree
Congestive heart failure 0.000271442 1 0 BeFree
Psychotic Disorders 0.000271442 1 1 BeFree
Tumor Progression 0.000271442 1 0 BeFree
Nonorganic psychosis 0.000271442 1 1 BeFree
Carcinoma of bladder 0.000271442 1 1 BeFree
Macroorchidism 0.000271442 1 0 BeFree
Xenograft Model 0.000271442 1 0 BeFree

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