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Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  G蛋白信号传导的调节器(RGS)家族成员是充当异的G蛋白G的阿尔法亚基GTP酶激活蛋白(GAP)调节分子。 RGS蛋白能够停用在Gi的αG蛋白亚基,转到α和Gq蛋白的α亚型。他们驾驶的G蛋白进入它们的无效GDP结合的形式。 G蛋白信号4的稳压器属于这个家庭。所有RGS蛋白共享一个保守的120个氨基酸的序列被称为RGS域。 G蛋白信号4蛋白的调节剂是37%相同RGS1和97%相??同的大鼠RGS4。这种蛋白负调控上游或在异源G蛋白的水平信令和在细胞质中被定位。另外剪接转录变体也发现了这种基因。 [由RefSeq的,2008年7月提供]
RGS4基因(以及对应的蛋白质)的细胞分布位置:
RGS4基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Schizophrenia | 0.216710349 | 49 | 4 | BeFree_CTD_human_GAD_LHGDN |
Endometriosis | 0.12 | 1 | 0 | CTD_human |
IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
Bipolar Disorder | 0.008544182 | 5 | 0 | BeFree_GAD_LHGDN |
Major Depressive Disorder | 0.002909916 | 2 | 0 | BeFree_GAD |
Alzheimer's Disease | 0.00272435 | 1 | 0 | LHGDN |
Alcoholic Intoxication, Chronic | 0.002638474 | 1 | 0 | BeFree_GAD |
Squamous cell carcinoma | 0.002367032 | 1 | 0 | GAD |
Head and Neck Neoplasms | 0.002367032 | 1 | 0 | GAD |
Hypertensive disease | 0.002367032 | 1 | 0 | GAD |
Liver Cirrhosis, Alcoholic | 0.002367032 | 1 | 0 | GAD |
Marijuana Abuse | 0.002367032 | 1 | 0 | GAD |
Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
Psychoses, Substance-Induced | 0.002367032 | 1 | 0 | GAD |
Schizoaffective Disorder | 0.002367032 | 1 | 0 | GAD |
Neoplasms, Second Primary | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Unipolar Depression | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000271442 | 1 | 1 | BeFree |
Fragile X Syndrome | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Heart failure | 0.000271442 | 1 | 0 | BeFree |
Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
Psychotic Disorders | 0.000271442 | 1 | 1 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Nonorganic psychosis | 0.000271442 | 1 | 1 | BeFree |
Carcinoma of bladder | 0.000271442 | 1 | 1 | BeFree |
Macroorchidism | 0.000271442 | 1 | 0 | BeFree |
Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
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