Physics in medicine and biology-基因文献库-基因云馆

标题

Physics in medicine and biology

摘要

Soft tissue stiffness was shown to significantly change after thermal ablation. To better understand this phenomenon, the study aims (1) to quantify and explain the temperature dependence of soft tissue stiffness for different organs, (2) to investigate the potential relationship between stiffness changes and thermal dose and (3) to study the reversibility or irreversibility of stiffness changes. Ex vivo bovine liver and muscle samples (N = 3 and N = 20, respectively) were slowly heated and cooled down into a thermally controlled saline bath. Temperatures were assessed by thermocouples. Sample stiffness (shear modulus) was provided by the quantitative supersonic shear imaging technique. Changes in liver stiffness are observed only after 45 degrees C. In contrast, between 25 degrees C and 65 degrees C, muscle stiffness varies in four successive steps that are consistent with the thermally induced proteins denaturation reported in the literature. After a 6 h long heating and cooling process, the final muscle stiffness can be either smaller or bigger than the initial one, depending on the stiffness at the end of the heating. Another important result is that stiffness changes are linked to thermal dose. Given the high sensitivity of ultrasound to protein denaturation, this study gives promising prospects for the development of ultrasound-guided HIFU systems.

作者

Sapin-de Brosses(E),Gennisson(J-L),Pernot(M),Fink(M),Tanter(M)

来源杂志

Phys Med Biol

首次收录时间

2010-03-03

最后更新时间

2016-11-25

issue

6

volume

55

iSOAbbreviation

Phys Med Biol

出版商

ppublish

来源国家

England

Temperature dependence of the shear modulus of soft tissues assessed by ultrasound.

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